Functionalized zeolite regulates bone metabolic microenvironment

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101558 - 101558

Published: Feb. 5, 2025

The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, defects, infections, and tumors remains a significant challenge orthopedics. Therefore, it has become urgent to develop biomaterials with effective microenvironmental regulatory functions. Zeolites, advanced biomedical materials, possess distinctive physicochemical properties multi-level pore structures, adjustable frameworks, easily modifiable surfaces, excellent adsorption capabilities. These advantageous characteristics give zeolites broad application prospects regulating the microenvironment. this paper first classifies used regulate based on their topological structures compositional frameworks. Subsequently, provides detailed description modification strategies for zeolite materials aimed at Next, comprehensive summary was provided preparation Additionally, focuses specific applications conditions imbalance, orthopedic tumors, highlighting potential enhancing osteogenic microenvironments, controlling treating tumors. Finally, outlines challenges associated This review comprehensively summarizes regulation, aiming provide guidance future research development.

Language: Английский

Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 28, 2025

Osteoporosis, a prevalent systemic metabolic bone disease, is characterized by diminished mass, microarchitectural deterioration of tissue, and heightened fragility. In osteoporotic patients, chronic progressive loss often leads to fractures and, in advanced cases, critical-sized defects. While traditional repair approaches are constrained significant limitations, the advent bioactive scaffolds has transformed therapeutic paradigm for regeneration. Among these innovations, natural polymer-based hydrogel have emerged as particularly promising solution tissue engineering, owing their superior biocompatibility, tunable biodegradation properties, exceptional ability replicate native extracellular matrix environment. This review systematically explores recent breakthroughs modification techniques applications defect repair, while critically analyzing existing clinical challenges proposing future research trajectories this rapidly evolving field.

Language: Английский

Mg–Sc alloy promotes angiogenesis–osteogenesis coupling and ameliorates steroid-induced osteonecrosis of the femoral head

Rare Metals, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский