A Carbon Nanotube/Pyrrolidonecarboxylic Acid Zinc Sponge for programmed management of Diabetic Wounds: Hemostatic, Antibacterial, Anti-inflammatory, and Healing Properties DOI Creative Commons
Chenwei Wu,

Liu Bo,

Qiulan Wen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101769 - 101769

Published: April 12, 2025

Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages lack comprehensive therapeutic approaches. This study introduces a novel approach using photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, water absorption properties. The incorporated pyrrolidonecarboxylic acid zinc (PC1Z2), compound anti-inflammatory moisturizing properties, which was cross-linked within network CNTs decellularized dermal matrix. resulting shape-memory actively interfaces endogenous electric fields, facilitating signal transmission skin cells accelerating tissue repair. Upon exposure near-infrared (NIR) light, the PC1Z2 enhanced antibacterial efficacy (98 %) through conversion, promoting metabolism at site. Notably, absorbed exudates gradually released Zn2+, effectively reducing inflammation mice. In diabetic rat model, exudates, reduced accelerated granulation formation, angiogenesis, re-epithelialization. innovative dressing shows promise enhancing wounds.

Language: Английский

Polysaccharides as therapeutic vehicles in pancreatic cancer DOI
Seema Kumari, Sujatha Peela,

Ganji Purnachandra Nagaraju

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104320 - 104320

Published: Feb. 1, 2025

Language: Английский

Citations

0
A Carbon Nanotube/Pyrrolidonecarboxylic Acid Zinc Sponge for programmed management of Diabetic Wounds: Hemostatic, Antibacterial, Anti-inflammatory, and Healing Properties DOI Creative Commons
Chenwei Wu,

Liu Bo,

Qiulan Wen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101769 - 101769

Published: April 12, 2025

Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages lack comprehensive therapeutic approaches. This study introduces a novel approach using photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, water absorption properties. The incorporated pyrrolidonecarboxylic acid zinc (PC1Z2), compound anti-inflammatory moisturizing properties, which was cross-linked within network CNTs decellularized dermal matrix. resulting shape-memory actively interfaces endogenous electric fields, facilitating signal transmission skin cells accelerating tissue repair. Upon exposure near-infrared (NIR) light, the PC1Z2 enhanced antibacterial efficacy (98 %) through conversion, promoting metabolism at site. Notably, absorbed exudates gradually released Zn2+, effectively reducing inflammation mice. In diabetic rat model, exudates, reduced accelerated granulation formation, angiogenesis, re-epithelialization. innovative dressing shows promise enhancing wounds.

Language: Английский

Citations

0