Functional Hydrogels for Implantable Bioelectronic Devices

Luminescence, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 1, 2025

ABSTRACT In recent years, with the rapid development of flexible electronics, implantable electronic devices have received increasing attention, and they provide new solutions for medical diagnosis treatment. To ensure long‐term stable operation in internal environment, materials conductivity, flexibility, biocompatibility, other properties are high demand. Hydrogels polymers three‐dimensional network structures that not only physical chemical similar to those biological tissues but can be also modulated by introducing functional groups regulate adhesion, self‐healing, functions. Therefore, hydrogel‐based bioelectronic considered a candidate direction future biomedical field. Here, this paper reviews research progress molecular design performance modulation functionalized hydrogels based on four key hydrogels: toughness. The latest use device applications is summarized below. Finally, discussions given challenges opportunities devices.

Language: Английский

Bioxolography Using Diphenyliodonium Chloride and N‐Vinylpyrrolidone Enables Rapid High‐Resolution Volumetric 3D Printing of Spatially Encoded Living Matter

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Light‐based volumetric bioprinting enables fabrication of cubic centimeter‐sized living materials with micrometer resolution in minutes. Xolography is a light sheet‐based printing technology that offers unprecedented generation rates and print resolutions for hard plastics. However, the limited solubility reactivity current dual‐color photoinitiators (DCPIs) aqueous media have hindered their application high‐resolution matter. Here, we present novel three‐component formulation drastically improves photoreactivity thereby high‐resolution, rapid, cytocompatible Xolographic biofabrication intricately architected yet mechanically robust materials. To achieve this, various relevant additives are systematically explored, which revealed diphenyliodonium chloride N ‐vinylpyrrolidone strongly enhance D‐mediated photoreactivity, as confirmed by photo‐rheology. This gelatin methacryloyl‐based bioresins, producing >1 cm 3 constructs at ≈20 µm positive 125 negative within Multimaterial printing, molecular patterning, grayscale‐mediated mechanical patterning explored to programmably create intricate, biomimetic, concentration‐controlled architectures. We demonstrate Bioxolographic cell types, showing excellent viability, compatibility long‐term culture, ability nascent protein deposition. These results position Bioxolography transformative platform scalable, functional encoded chemical properties.

Language: Английский