Harnessing unique architecture and emerging strategies of solid lipid nanoparticles to combat colon cancer: A state-of-the-art review DOI Creative Commons
Ashutosh Gupta, Shraddha Vikas Jadhav,

Viola Colaco

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125562 - 125562

Published: April 1, 2025

Cancer is a serious worldwide public health problem, ranking as the second leading cause of death in United States. The third most prevalent tumor kind world colon or rectal tumor. Colon (CC) common cancer and cancer-related deaths globally. In US, CC has become 2nd after having different advancements like detection, surgery, chemotherapy. current strategies for treating have several disadvantages, including higher toxicity, drug resistance, damage to healthy cells, solubility, specificity, lower therapeutic index, more. Solid lipid nanoparticles (SLNs) are viable targeted treatment option avoid this problem. This comprehensive review discussed severity, pathophysiology, risk factors, stages cancer. covers effective therapy diagnostic procedures, HSgFOBT, Fecal immunological test (FIT), Colonoscopy, FIT-DNA Test/mt-sDNA screening test, capsule (CCE), Blood-based DNA Tests, Flexible sigmoidoscopy. reviewemphasizes need novel specific approaches improve patient outcomes.

Language: Английский

Poloxamer-based drug delivery systems: Frontiers for treatment of solid tumors DOI Creative Commons

Mehdi Pourbakhsh,

Masoud Jabraili,

Morteza Akbari

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101727 - 101727

Published: April 1, 2025

Pluronics or poloxamers are a type of triblock copolymer. These non-ionic molecules consist hydrophobic block embedded in two hydrophilic parts. have become favorite materials for use the field biomedical research due to having favorable physicochemical and biological properties such as amphiphilicity, solubility ionic solutions, biocompatibility, biodegradability, self-assembly low toxicity. The scope these applications can vary from tissue engineering drug delivery. One important uses pluronics is deliver drugs various cancer cells. Herein we first provide an overview on variety ploronic biomaterials. And then intensively evaluate their potential delivery systems (DDSs) treatment solid tumors with special focus breast cancers. After explaining pros cons pluronics, current status clinical settings future prospects highlighted.

Language: Английский

Citations

0
Harnessing unique architecture and emerging strategies of solid lipid nanoparticles to combat colon cancer: A state-of-the-art review DOI Creative Commons
Ashutosh Gupta, Shraddha Vikas Jadhav,

Viola Colaco

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125562 - 125562

Published: April 1, 2025

Cancer is a serious worldwide public health problem, ranking as the second leading cause of death in United States. The third most prevalent tumor kind world colon or rectal tumor. Colon (CC) common cancer and cancer-related deaths globally. In US, CC has become 2nd after having different advancements like detection, surgery, chemotherapy. current strategies for treating have several disadvantages, including higher toxicity, drug resistance, damage to healthy cells, solubility, specificity, lower therapeutic index, more. Solid lipid nanoparticles (SLNs) are viable targeted treatment option avoid this problem. This comprehensive review discussed severity, pathophysiology, risk factors, stages cancer. covers effective therapy diagnostic procedures, HSgFOBT, Fecal immunological test (FIT), Colonoscopy, FIT-DNA Test/mt-sDNA screening test, capsule (CCE), Blood-based DNA Tests, Flexible sigmoidoscopy. reviewemphasizes need novel specific approaches improve patient outcomes.

Language: Английский

Citations

0