Au Deposition Enhanced Fenton-like Chemistry within a Metal–Organic Framework DOI

Zhining Yuan,

Yehong Wan,

Ling Zhang

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Chemodynamic therapy (CDT), which regulates oxidative stress in tumor tissues, has emerged as a promising alternative. However, the efficiency of MOF-based Fenton catalysts for CDT still needs improvement. This study presents strategy to improve catalytic performance ZnCo-ZIF by depositing Au nanoparticles on its surface. Monodisperse particles (≤200 nm) were prepared optimizing Zn/Co ratio, and deposition enhanced electron transfer between Co, increasing charge density around Co atoms. resulted 2.28-fold improvement activity under acidic conditions mild near-infrared (NIR) light. Loading system with natural product naringin (NA) molecule further demonstrated synergistic anticancer effects vitro. work offers insights into enhancing cancer therapy.

Language: Английский

Au Deposition Enhanced Fenton-like Chemistry within a Metal–Organic Framework DOI

Zhining Yuan,

Yehong Wan,

Ling Zhang

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Chemodynamic therapy (CDT), which regulates oxidative stress in tumor tissues, has emerged as a promising alternative. However, the efficiency of MOF-based Fenton catalysts for CDT still needs improvement. This study presents strategy to improve catalytic performance ZnCo-ZIF by depositing Au nanoparticles on its surface. Monodisperse particles (≤200 nm) were prepared optimizing Zn/Co ratio, and deposition enhanced electron transfer between Co, increasing charge density around Co atoms. resulted 2.28-fold improvement activity under acidic conditions mild near-infrared (NIR) light. Loading system with natural product naringin (NA) molecule further demonstrated synergistic anticancer effects vitro. work offers insights into enhancing cancer therapy.

Language: Английский

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