Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering
Computation,
Journal Year:
2024,
Volume and Issue:
12(4), P. 74 - 74
Published: April 4, 2024
Three-dimensional
porous
scaffolds
are
substitutes
for
traditional
bone
grafts
in
tissue
engineering
(BTE)
applications
to
restore
and
treat
injuries
defects.
The
use
of
computational
modelling
is
gaining
momentum
predict
the
parameters
involved
healing
cell
seeding
procedures
perfusion
bioreactors
reach
final
goal
optimal
growth.
Computational
based
on
finite
element
method
(FEM)
fluid
dynamics
(CFD)
two
standard
methodologies
utilised
investigate
equivalent
mechanical
properties
scaffolds,
as
well
flow
characteristics
inside
respectively.
success
a
simulation
hinges
selection
relevant
mathematical
model
with
proper
initial
boundary
conditions.
This
review
paper
aims
provide
insights
researchers
regarding
appropriate
(FE)
models
different
materials
CFD
regimes
bioreactors.
Thus,
these
FEM/CFD
may
help
create
efficient
designs
by
predicting
their
structural
haemodynamic
responses
prior
vitro
vivo
(TE)
applications.
Language: Английский
Unidirectional Polyvinylidene/Copper-Impregnated Nanohydroxyapatite Composite Membrane Prepared by Electrospinning with Piezoelectricity and Biocompatibility for Potential Ligament Repair
Polymers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 185 - 185
Published: Jan. 14, 2025
Ligament
tears
can
strongly
influence
an
individual’s
daily
life
and
ability
to
engage
in
physical
activities.
It
is
essential
develop
artificial
scaffolds
for
ligament
repairs
order
effectively
restore
damaged
ligaments.
In
this
experiment,
the
objective
was
evaluate
fibrous
membranes
as
repair.
These
were
created
through
electrospinning
using
piezoelectric
polyvinylidene
fluoride
(PVDF)
composites,
which
contained
1
wt.%
3
of
copper-impregnated
nanohydroxyapatite
(Cu-nHA).
The
proposed
electrospun
membrane
would
feature
aligned
fiber
structure
achieved
high-speed
roller
stretching,
mimics
properties
biomimetic
Nanoparticles
Cu-nHA
had
been
composited
into
PVDF
enhance
pirzoelectric
β-phase
crystallines.
study
assessed
physicochemical
properties,
antibacterial
activity,
biocompatibility
vitro.
A
microstructure
analysis
revealed
that
composite
exhibited
a
bionic
with
fibers
resembling
human
performance
experimental
group
containing
significantly
improved
25.02
±
0.68
V/g·m−2
compared
pure
at
18.98
1.18
V/g·m−2.
Further
enhancement
by
31.8%
manipulating
semicrystalline
structures.
Antibacterial
cytotoxicity
tests
showed
inherited
nanoparticles
without
causing
cytotoxic
reactions.
Tensile
membrane’s
flexibility
strain
adequate
use
particular,
mechanical
two
groups
enhanced
those
group.
favorable
flexible
are
highly
beneficial
tissue
regeneration.
This
successfully
developed
PVDF/Cu-nHA
biocompatible,
unidirectional
potential
applications
repair
scaffolds.
Language: Английский
Optimising the manufacturing of electrospun nanofibrous structures for textile applications: a machine learning approach
Journal of the Textile Institute,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: March 18, 2025
Language: Английский
Abstracts of the 1st International Online Conference on Bioengineering
Published: March 20, 2025
The
1st
International
Online
Conference
on
Bioengineering
(IOCBE
2024)
was
held
online
from
16
to
18
October
2024.
With
a
theme
of
in
Generative
AI
World,
the
conference
featured
presentations
distinguished
scholars
at
nexus
engineering
and
clinics,
food,
industry,
innovations
bioengineering
education.
organized
around
six
topics
related
themes:
Regenerative
Tissue
Engineering;
Biomechanics
Sports
Medicine;
Biomedical
Biomaterials;
Nano-Biotechnology;
Biosignal
Processing;
Biochemical
Engineering.
This
discussed
important
recent
developments
bioengineering,
including
bioengineered
foods,
allotransplantation,
multi-omics,
theragnostics
convergence.
Oral
poster
were
live
broadcasts,
enabling
participants
take
part
interactive
discussions
sessions.
Language: Английский
Machine learning to mechanically assess 2D and 3D biomimetic electrospun scaffolds for tissue engineering applications: Between the predictability and the interpretability
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
157, P. 106630 - 106630
Published: June 17, 2024
Currently,
the
use
of
autografts
is
gold
standard
for
replacement
many
damaged
biological
tissues.
However,
this
practice
presents
disadvantages
that
can
be
mitigated
through
tissue-engineered
implants.
The
aim
study
to
explore
how
machine
learning
mechanically
evaluate
2D
and
3D
polyvinyl
alcohol
(PVA)
electrospun
scaffolds
(one
twisted
filament,
3
filament
twisted/braided
scaffolds)
their
in
different
tissue
engineering
applications.
Crosslinked
non-crosslinked
were
fabricated
characterised,
dry/wet
conditions
under
longitudinal/transverse
loading,
using
tensile
testing.
28
models
(ML)
used
predict
mechanical
properties
scaffolds.
4
exogenous
variables
(structure,
environmental
condition,
crosslinking
direction
load)
2
endogenous
(Young's
modulus
ultimate
strength).
ML
able
identify
6
structures
testing
with
comparable
Young's
strength
ligamentous
tissue,
skin
oral
nasal
renal
tissue.
This
novel
proved
Classification
Regression
Trees
(CART)
an
innovative
easy
interpret
tool
biomimetic
structures;
however,
Cubist
Support
Vector
Machine
(SVM)
most
accurate,
R
Language: Английский
Machine learning to predict morphology, topography and mechanical properties of sustainable gelatin-based electrospun scaffolds
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Sept. 9, 2024
Language: Английский
Tailoring the Morphological Properties of PVA Nanofibrous Mats by Manipulating Working Planes
Journal of Nanotechnology,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Despite
the
process,
solution,
and
ambient
parameters
of
electrospinning
technique
have
been
intensely
studied,
effects
different
setup
orientations
not
thoroughly
investigated.
In
many
research
studies,
attempts
on
polyvinyl
alcohol
performed
with
a
horizontal
or
researchers
even
mentioned
orientation.
This
paper
examines
morphological
properties
alcohol‐based
fibrous
mats
electrospun
same
apparatus
identical
process
solution
but
working
planes,
namely,
(x)‐axis,
(+y)
axis,
(−y)
axis.
From
test
results,
it
is
concluded
that
axis
most
versatile
plane
because
finest
nanofiber
diameters
lowest
diameter
variation,
medium‐level
pore
area
smallest
sizes.
Besides,
highest
packing
density
highly
deposited
structure
longest
fibers
high
aspect
ratio
are
constructed
in
this
more
favorable
than
other
planes
for
permeable
membranes
biostructures.
Language: Английский