Electroactive biomaterials synergizing with electrostimulation for cardiac tissue regeneration and function-monitoring

Materials Today, Journal Year: 2023, Volume and Issue: 70, P. 237 - 272

Published: Sept. 30, 2023

Cardiac cells are assembled within a complicated microenvironment possessing diverse biochemical and biophysical cues that modulate cellular behaviors tissue functions. Apart from the widely studied pathways of regulation, positive effects electrical on regeneration excitable cardiac tissues have been demonstrated. Conductive biomaterials emerged as important two-way media to facilitate transmission endogenous bioelectricity or exogenous stimuli strengthening regeneration, while in meantime allow online monitoring bioelectrical activities. Mechanical energy exists prevalently heart, which brings huge promise building self-powered, enabled, on-demand stimulation system by using piezoelectric biomaterials. In this regard, conductive synergizing with electrostimulation for function-monitoring engineering comprehensively reviewed. After biological conduction human heart is firstly introduced, electroactive display biomimetic microenvironmental (e.g., electrical, mechanical, topological) their mediated summarized. Subsequently, current state systematically overviewed together underlying mechanisms modulating cell Furthermore, recent advances used function discussed. Finally, remaining challenges 3D complex designs, systematic parameter optimizations mechanisms, long-term performance, biosafety laid out, call interdisplinary joint forces innovation advancement.

Language: Английский

---

Exploring Present and Future Directions in Nano-Enhanced Optoelectronic Neuromodulation

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(9), P. 1398 - 1410

Published: April 23, 2024

ConspectusElectrical neuromodulation has achieved significant translational advancements, including the development of deep brain stimulators for managing neural disorders and vagus nerve seizure treatment. Optoelectronics, in contrast to wired electrical systems, offers leadless feature that guides multisite high spatiotemporal system targeting, ensuring specificity precision therapies known as "photoelectroceuticals". This Account provides a concise overview developments novel optoelectronic nanomaterials are engineered through innovative molecular, chemical, nanostructure designs facilitate interfacing with efficiency minimally invasive implantation.This outlines progress made both within our laboratory across broader scientific community, particular attention implications materials innovation strategies, studying bioelectrical activation methods, applications regenerative medicine. In innovation, we highlight nongenetic, biocompatible, approach spans various length scales, from single neurons tissues using nanosized particles monolithic membranes. Furthermore, discussion exposes critical unresolved questions field, mechanisms interaction at nanobio interface, cellular or tissue integration into existing networks modulation. addition, present challenges pressing needs long-term stability biocompatibility, scalability clinical applications, noninvasive monitoring control systems.In addressing field interfaces, particularly envisage promising strategic directions could significantly advance this burgeoning domain. involves deeper theoretical understanding nanobiointerfaces, where simulations experimental validations on how interact spatiotemporally biological systems crucial. The more durable is vital prolonged dynamic ability manipulate activity spatial resolution, paves way targeting individual specific circuits. Additionally, integrating these interfaces advanced possibly leveraging artificial intelligence machine learning algorithms programming dynamically responsive designs, ease implementation stimulation recording. These innovations hold potential introduce treatment modalities wide range neurological systemic disorders.

Language: Английский

---

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and integration of grafted cells. Biomaterials have emerged as an attractive solution to this problem providing a protective microenvironment deliver cells injured tissues. The design biomaterials compatible with tissues promote tissue repair functional recovery focus neural engineering. A wealth research has explored different materials architectures combination bioactive cues glial cell growth maturation. After brief presentation biomaterial strategies sources, we review vivo evidences about efficacy stem cotransplantation (i) enhancing trophic effects, (ii) increasing integration, (iii) achieving preclinical models stroke, traumatic brain injury, Parkinson's disease, spinal cord injury. Furthermore, comprehensive perspective was offered regarding specific implementation tactics, obstacles, development orientations employing critical support transplantation.

Language: Английский

---

Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues

Nature Reviews Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

---

Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: April 18, 2024

Abstract Biomodulation facilitated by external remote fields, such as those generated magnetic, optical, and acoustic stimuli, has emerged an intriguing avenue for tissue biofabrication, owing to their precision non‐invasive characteristics. The active modulation of 3D structures through cellular signaling transductions, encompassing thermo‐, mechano‐, electro‐transduction, proven highly effective in inducing spatiotemporally controlled, 4D compositional functional maturation. This review aims highlight the current progress unveil underlying mechanisms achieved with these leadless strategies. Additionally, it addresses existing challenges opportunities associated distinct approaches. Finally, a few new directions briefly outlined, unfolds future perspectives continual advancement.

Language: Английский

---

Nanofibers Loaded with Nonthermal Nitrogen Plasma-Treated g-C₃N₄ for Efficient Visible Light-Driven Photodegradation of Omethoate

ACS Agricultural Science & Technology, Journal Year: 2023, Volume and Issue: 3(6), P. 543 - 551

Published: June 1, 2023

Photocatalytic degradation is an effective strategy to reduce food safety risks caused by the residual organophosphorus pesticide omethoate in fruits and vegetables. In order avoid secondary pollution of photocatalysts costs, this paper, visible light-driven photocatalytic active composite nanofibers were successfully synthesized loading nonthermal nitrogen plasma-treated graphite carbon nitride (g-C3N4) onto poly(ethylene oxide) nanofibers. When amount was 0.5%, photodegradation rate highest. Although treatment high-power plasma does not significantly affect chemical structure g-C3N4, it can change abundance its surface reactive sites. This modification improved activity increasing photocurrent intensity more than 90% 100%. Possible mechanisms have also been discussed. work further enhance application potential g-C3N4 field degradation.

Language: Английский

---

Mechanical memory based biofabrication of hierarchical elastic cardiac tissue

Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 015013 - 015013

Published: Oct. 22, 2024

Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance 3D cellular orientation is essential in designing bionic scaffolds tissue biofabrication. Here, a hierarchically organized, wavy and conductive polycaprolactone/Au scaffold was created facile fashion based on mechanical memory during fabrication. The shows good biocompatibility, excellent biomimetic properties that guide myoblast alignment, support hyperelastic behavior observed native muscle tissue, promote myotube maturation, which holds potential engineering establishment anin vitroculture platform drug screening.

Language: Английский

---

Organic opto-nanobiointerface enables multiscale biomodulation

Published: Oct. 25, 2024

Abstract Virtually all organic material on Earth has been produced converting solar energy through photosynthesis in chloroplasts, a sack-like, double membrane organelle plants and algae, where transmembrane electron transfer occurs from lumen to stroma. Although animals hardly harness the power of photosynthesis, their bioelectrical signals extensively regulate complex electrophysiological behaviors, rendering it superior target for biomedical innovation. Here crude structural mimicry chloroplast led us discover that hollow sphere graphitic carbon nitride nanoparticles (hg-C 3 N 4 NPs) endowed non-genetic, subcellular intercellular photo-modulation various excitable non-excitable cells, accumulatively achieving modulation at tissue/organ function level. The homogeneous hg-C NPs showed photo-responsiveness via photoelectrochemical photothermal mechanisms under photocurrent measurement. can be spontaneously internalized with excellent cytocompatibility. Using focusing laser, enable intracellular optical stimulation resolution, inducing calcium transient release multiple cells propagation primary cardiomyocytes cardiac fibroblasts. At multicellular scale, pacing synchronization cardiomyocyte beating is achieved facilely by LED. Further, we demonstrate safely injected into mouse eyes, restoring light sensitivity blind mice. Finally, application porcine retinal tissue ex vivo confirmed capability reactivate RGCs activity LED photostimulation. Taken together, these nanostructured biomimic semiconductor offer high leadless probing, non-invasive delivery great biocompatibility, serving as versatile tool addressing range challenges subcellular, tissue-level across broad spectrum scales.

Language: Английский

---

Biomimic opto-nanobiointerface enables multiscale biomodulation

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Virtually all organic material on Earth has been produced converting solar energy through photosynthesis in chloroplasts, a sack-like, double membrane organelle plants and algae, where transmembrane electron transfer occurs from lumen to stroma. Although animals hardly harness the power of photosynthesis, their bioelectrical signals extensively regulate complex electrophysiological behaviors, rendering it superior target for biomedical innovation. Here crude structural mimicry chloroplast led us discover that hollow sphere graphitic carbon nitride nanoparticles (hg-C₃N₄ NPs) endowed non-genetic, subcellular intercellular photo-modulation various excitable non-excitable cells, accumulatively achieving modulation at tissue/organ function level. The homogeneous hg-C₃N₄ NPs showed photo-responsiveness via photoelectrochemical photothermal mechanisms under photocurrent measurement. can be spontaneously internalized with excellent cytocompatibility. Using focusing laser, enable intracellular optical stimulation resolution, inducing calcium transient release multiple cells propagation primary cardiomyocytes cardiac fibroblasts. At multicellular scale, pacing synchronization cardiomyocyte beating is achieved facilely by LED. Further, we demonstrate safely injected into mouse eyes, restoring light sensitivity blind mice. Finally, application porcine retinal tissue ex vivo confirmed capability reactivate RGCs activity LED photostimulation. Taken together, these nanostructured biomimic semiconductor offer high leadless probing, non-invasive delivery great biocompatibility, serving as versatile tool addressing range challenges subcellular, tissue-level across broad spectrum scales.

Language: Английский

---