Bulletin of the Lebedev Physics Institute, Journal Year: 2024, Volume and Issue: 51(S11), P. S962 - S968
Published: Dec. 1, 2024
Language: Английский
Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 112086 - 112086
Published: Nov. 13, 2024
Language: Английский
Citations
6
Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3936 - 3936
Published: Aug. 21, 2024
Boron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of on tumor cells, and this modality can further be improved by use boron nanoparticles (B NPs) local sensitizers achieve enhanced targeted therapeutic outcomes. However, mechanisms cell elimination under boron-enhanced still require clarification. Here, we explore possible molecular responsible for enhancement outcomes NP-enhanced therapy. Spherical B NPs with mode size 25 nm were prepared methods pulsed laser ablation in water, followed their coating polyethylene glycol improve colloidal stability buffers. Then, assessed cancer killing irradiation 160.5 MeV beam. Our experiments showed that combined effect induces an increased level superoxide anion radical generation, which leads depolarization mitochondria, drop membrane mitochondrial potential, development apoptosis. A comprehensive gene expression analysis (via RT-PCR) confirmed overexpression 52 genes (out 87 studied) involved redox status oxidative stress, compared 12 cells irradiated without NPs. Other NPs-induced radiosensitizing effect, including one related generation alpha particles, are discussed. The obtained results give better insight into processes boron-induced enable optimize parameters order maximize
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 515 - 515
Published: April 15, 2025
Proton beam therapy (PBT) is a rapidly advancing modality of hadron therapy. The primary advantage proton lies in unique depth-dose distribution characterized by the Bragg peak, which enables highly targeted irradiation area limited to tumor, while minimizing impact on healthy tissues. However, broader clinical adoption ion both economic and radiobiological constraints. One possible ways increase relative biological effectiveness (RBE) involves use radiosensitizers. Background/Objectives: In this work, we investigated efficacy using colloidal solutions lanthanum hexaboride (LaB6) nanoparticles (NPs) coated with polyacrylic acid (PAA) as sensitizers antitumor irradiation. This material has not yet been studied extensively so far, despite its promising physical chemical properties several reports biocompatibility. Methods: LaB6 NPs were synthesized femtosecond pulsed laser ablation, functionalized PAA characterized. safety was evaluated vitro Live/Dead assay cell cultures: EMT6/P, BT-474, vivo Balb/c mice after intravenous (i.v.) administration. binary model human ductal carcinoma mammary gland BT-474 female Nu/j intratumoral (i.t.) administration at dose 2.0 mg/mouse local (fractional exposure 31 Gy + 15 Gy). biodistribution LaB6-PAA animal body also evaluated. Results: Significant enhancement cancer death following demonstrated lines. Although observed comparatively lower—likely due high sensitivity xenografts—both monotherapy treatment well tolerated. Conclusions: show promise efficient capable enhancing therapy, offering potential path forward for improving therapeutic outcomes.
Language: Английский
Citations
0
Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102714 - 102714
Published: March 15, 2025
Language: Английский
Citations
0
Bulletin of the Lebedev Physics Institute, Journal Year: 2025, Volume and Issue: 52(2), P. 95 - 102
Published: Feb. 1, 2025
Language: Английский
Citations
0
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 198, P. 107131 - 107131
Published: Nov. 16, 2024
Language: Английский
Citations
0
Bulletin of the Lebedev Physics Institute, Journal Year: 2024, Volume and Issue: 51(S11), P. S962 - S968
Published: Dec. 1, 2024
Language: Английский
Citations
0