Published: Jan. 1, 2024
Language: Английский
Nutrition, Journal Year: 2024, Volume and Issue: 119, P. 112350 - 112350
Published: Jan. 2, 2024
Language: Английский
Citations
18
Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1316 - 1316
Published: May 8, 2024
Bacterial infections have a serious impact on public health. It is urgent to develop antibacterial hydrogels with good biocompatibility reduce the use of antibiotics. In this study, poly(lipoic acid-co-sodium lipoate)–phytic acid (P(LA-SL)-PA) are prepared by simple mixture natural small molecules lipoic (LA) and phytic (PA) in mild green reaction environment. The crosslinking network constructed through connection covalent disulfide bonds as well hydrogen bonds, which endow injectable self-healing properties. P(LA-SL)-PA exhibit an adjustable compression modulus adhesion. vitro agar plates assay indicates that rate against Escherichia coli Staphylococcus aureus close 95%. rat-infected wound model, adhere closely tissue promote epithelialization collagen deposition significant effect healing. These results prove could act effective dressings for promoting healing infected wounds.
Language: Английский
Citations
8
Cosmetics, Journal Year: 2023, Volume and Issue: 10(5), P. 142 - 142
Published: Oct. 12, 2023
Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.
Language: Английский
Citations
13
Allergy, Journal Year: 2024, Volume and Issue: 79(12), P. 3269 - 3284
Published: Nov. 1, 2024
Abstract Human skin is colonized with microbiota that includes commensal bacteria, fungi, arthropods, archaea and viruses. The composition of the varies at different anatomical locations according to changes in body temperature, pH, humidity/hydration or sebum content. A homeostatic crucial maintain epithelial barrier functions, protect from invading pathogens interact immune system. Therefore, maintaining homeostasis holds promise be an achievable goal for microbiome‐directed treatment strategies as well a prophylactic strategy prevent development diseases, dysbiosis disruption associated inflammation. healthy microbiome likely modulated by genetic environmental lifestyle factors. In this review, we aim provide complete overview factors can contribute healthy. Awareness these could basis diseases used therapeutic approach.
Language: Английский
Citations
5
Developmental Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Adult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical other age groups are limited. This study aimed to explore the chronological maturation of barrier various regions. A TaqMan low-density array immunohistochemical immunofluorescence detection cells mediators sebaceous gland-rich (SGR) gland-poor (GP) healthy were performed children, adolescents, adults. The SGR showed a general upward trend mRNA levels most Th17-related molecules significant increase IL-1B from childhood adulthood, but only slight elevation between adolescence. In addition, T cell, Treg, dendritic cell (DC) counts, as well several proteins (IL-17, IL-10, IL-23, CCL20, S100A8, sfTSLP, LCN2), increased significantly age. GP skin, AHR decreased, while protein increased, although moderately. When comparing two similar childhood, emerging adolescence becoming particularly IL-17 pathway, mainly produced by Th17 cells. Our results show similarly directed process more pronounced development (with infiltration cytokine production) during after is likely be related changes chemical microbiota barriers adolescence, may explain high incidence inflammatory diseases highlighting need for targeted care this region.
Language: Английский
Citations
0
Journal of Dermatological Treatment, Journal Year: 2025, Volume and Issue: 36(1)
Published: April 21, 2025
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by barrier dysfunction and immune dysregulation, often leading to increased allergen penetration, sensitization, secondary infections. Colloidal oat emollients are widely used in adult AD management, but their role pediatric treatment, prevention, allergy modulation remains under investigation. A comprehensive literature review evaluated clinical preclinical studies on colloidal oat-containing treatment prevention. Studies assessing function, modulation, food risk, healthcare utilization were included. improved hydration, reduced transepidermal water loss (TEWL), supported repair, fewer flares reliance steroid treatments. suggest that early, consistent use of advanced emollient formulations may lower incidence high-risk infants reduce sensitization rates. Real-world data indicate patients using have clinic visits overall costs. Concerns about remain unsubstantiated most studies. effective, well-tolerated, cost-efficient for management. Their barrier-restorative anti-inflammatory properties risk. Future research should focus head-to-head comparisons optimize strategies.
Language: Английский
Citations
0
Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 661 - 661
Published: May 15, 2024
Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of cancer. While existing serve this purpose, there is growing need to enhance their efficacy while minimizing potential systemic absorption UV filters and associated toxicological risks. Liposomal-based formulations have emerged as promising approach address these challenges develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic lipophilic filters, enabling creation broad-spectrum sunscreens. Moreover, composition based on phospholipids, resembling that stratum corneum, facilitates adherence skin’s surface layers, thereby improving efficacy. The research discussed review underscores significant advantages liposomes photoprotection, including ability limit formulation stability, augment effects. However, despite benefits, remains notable gap between liposomal utilization sunscreen development. Consequently, emphasizes importance leveraging related innovative tools crafting novel more efficient formulations.
Language: Английский
Citations
3
Cell organoid (Print), Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
Surgery is the primary treatment for skin tumors, but it can result in scarring and distress patients. Developing alternative therapeutic methods necessitates suitable in vitro models, which are currently limited accurately representing vivo cell types microenvironment of tumors. Here, we present a practical approach creating patient-derived tumor organoids that effectively replicate histological characteristics mutational profiles observed clinical tissues. Utilizing single-cell sequencing, identified up to 11 distinct within organoid samples, encompassing various system cells immune cells. Furthermore, demonstrate applicability bermatofibrosarcoma protuberans (DFSP) assessing their responses imatinib metformin. Our findings reveal metformin, contrast imatinib, modulate expression downstream genes through signaling pathways. results underscore ability DFSP preserve key features tissues, including presence multiple types, especially Importantly, our provide convenient investigating effects drugs elucidating underlying molecular mechanisms.
Language: Английский
Citations
3