The role of macrophages in chronic rhinosinusitis with nasal polyps

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by dysbiosis of microbiota and dysregulation the immune system. Macrophages are essential for protecting against infections, but their roles mechanisms in CRSwNP not fully understood. To date, we gradually recognize heterogeneity macrophages, new subsets macrophages have been identified at transcriptional level due to development single cell RNA‐sequencing. In this review, summarize generation, polarization, phenotype identification, function CRSwNP, providing a comprehensive understanding CRSwNP. Additionally, also explore how interact other cells, including epithelial neurons, which can worsen inflammation. A better role could improve ability clear bacteria reduce chronic inflammation might be clinically beneficial patients.

Language: Английский

Nasal vaccines for respiratory infections

Nature, Journal Year: 2025, Volume and Issue: 641(8062), P. 321 - 330

Published: May 7, 2025

Language: Английский

Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface

Trends in Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский