Glial-immune interactions in barrier organs DOI Creative Commons
Juha Karjalainen, Sofia Hain, Fränze Progatzky

et al.

Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Neuroimmune mechanisms of type 2 inflammation in the skin and lung DOI Creative Commons
Masato Tamari, Aaron Ver Heul

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Type 2 inflammation has a major role in barrier tissues such as the skin and airways underlies common conditions including atopic dermatitis (AD) asthma. Cytokines interleukin 4 (IL-4), IL-5, IL-13 are key immune signatures of type targets multiple specific therapeutics for allergic diseases. Despite shared core mechanisms, distinct structures functions lead to unique therapeutic responses. It is increasingly recognized that nervous system sensing directing inflammatory processes. Indeed, crosstalk between activation somatosensory mediates tissue-specific itching skin. However, neuroimmune interactions shaped by neuronal landscapes, differ airways. In skin, dorsal root ganglia-derived neurons mediate pruritus via cytokines neurogenic mast cell or basophil activation. Conversely, vagal regulate airway responses releasing neuropeptides/neurotransmitters calcitonin gene-related peptides, neuromedin U, acetylcholine, noradrenaline. Sensory neuron-derived vasoactive intestinal peptide forms feedback loop with amplifying eosinophilic airways, mechanism absent These differences influence efficacy cytokine-targeted therapies. For instance, IL-4/IL-13-targeted therapies like dupilumab demonstrate AD diseases, whereas IL-5-targeted effective asthma but not AD. Understanding these underscores need tailored approaches address diseases where involved.

Language: Английский

Citations

1
Emerging roles of mechanically activated ion channels in autoimmune disease DOI

Zhiru Zeng,

Engeng Chen, Jing Xue

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(7), P. 103813 - 103813

Published: April 7, 2025

Language: Английский

Citations

0
Neuropeptides or their receptors in pathogenesis of lung diseases and therapeutic potentials DOI
Changgen Li, Na Zang, Enmei Liu

et al.

Neuropeptides, Journal Year: 2024, Volume and Issue: 108, P. 102482 - 102482

Published: Nov. 2, 2024

Language: Английский

Citations

0
Glial-immune interactions in barrier organs DOI Creative Commons
Juha Karjalainen, Sofia Hain, Fränze Progatzky

et al.

Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0