Mode and Mechanism of Action of Omega-3 and Omega-6 Unsaturated Fatty Acids in Chronic Diseases DOI Open Access
Rugen Xu, Adrian Molenaar, Zhi Chen

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1540 - 1540

Published: April 30, 2025

Unsaturated fatty acids, particularly omega-3 and omega-6 polyunsaturated have garnered increasing scientific interest due to their therapeutic potential in chronic disease management. Dietary sources such as milk provide essential unsaturated including linoleic acid α-linolenic acid. Current evidence indicates that these compounds derivatives regulate critical physiological processes, neurodevelopment, visual function, immune modulation, cardiovascular homeostasis. Their multifunctional roles encompass the structural maintenance of biological membranes, cardioprotective effects, anti-inflammatory anti-tumor activities, metabolic regulation. However, despite established associations between acids diseases, mechanistic contributions complex neuropsychiatric disorders remain poorly characterized. Furthermore, controversial role pathogenesis necessitates urgent clarification. This review systematically examines properties, molecular mechanisms, applications diabetes, cancer, dermatological conditions, neurodegenerative disorders, depression. By integrating recent advances dietary science, this work aims address knowledge gaps implications refine evidence-based strategies for intervention through optimized nutritional approaches.

Language: Английский

Metabolic Targeting for Control of IL-9 DOI

Jacquelyn D. Lajiness,

Mark H. Kaplan

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy DOI Creative Commons
Hua Jiang, Sam P. Limsuwannarot, Kayla Kulhanek

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

SUMMARY Arming T cells with a synthetically orthogonal IL-9 receptor (o9R) permits facile engraftment and potent anti-tumor functions. We considered whether the paucity of natural IL-9R expression could be exploited for cell immunotherapy given that, in mice, high doses were well-tolerated without discernible immune modulation. Compared to o9R, engineered exhibit superior tissue infiltration, stemness, activity. These qualities are consistent stronger JAK/STAT signal, which addition STAT1/3/5, unexpectedly includes STAT4 (canonically associated IL-12 but not common γ-chain cytokines). exquisitely sensitive perturbations proximal signaling, including structure-guided attenuation, amplification, rebalancing signals. Biased mutants uncover STAT1 as rheostat between proliferative stem-like terminally differentiated effector states. In summary, we identify native IL-9/IL-9R cytokine-receptor pair near-orthogonal an optimal signaling profile therapy.

Language: Английский

Citations

0
Targeting γc family cytokines with biologics: current status and future prospects DOI Creative Commons
Fabian Bick, Christophe Blanchetot, Bart N. Lambrecht

et al.

mAbs, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 18, 2025

Over the recent decades market potential of biologics has substantially expanded, and many top-selling drugs worldwide are now monoclonal antibodies or antibody-like molecules. The common gamma chain (γc) cytokines, Interleukin (IL-)2, IL-4, IL-7, IL-9, IL-15, IL-21, play pivotal roles in regulating immune responses, from innate to adaptive immunity. Dysregulation cell signaling by these cytokines is strongly associated with a range immunological disorders, which includes cancer as well autoimmune inflammatory diseases. Given essential role γc maintaining homeostasis, development therapeutic interventions targeting molecules poses unique challenges. Here, we provide an overview current either single multiple their respective receptor subunits across spectrum diseases, primarily focusing on antibodies, constructs, antibody-cytokine fusions. We summarize currently clinical trials, highlighting how they may offer advantages over existing therapies standard care, discuss advances this field. Finally, explore future directions novel intervention strategies cytokine family.

Language: Английский

Citations

0
Advances in the diagnosis of early biomarkers for acute kidney injury: a literature review DOI Creative Commons
Haifeng Yang, Yanqin Chen, Jiajia He

et al.

BMC Nephrology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 5, 2025

Acute kidney injury (AKI) is a critical condition with diverse manifestations and variable outcomes. Its diagnosis traditionally relies on delayed indicators such as serum creatinine urine output, making early detection challenging. Early identification essential to improving patient outcomes, driving the need for novel biomarkers. Recent advancements have identified promising biomarkers across various biological processes. Tubular markers, including neutrophil gelatinase-associated lipocalin (NGAL), molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), liver-type fatty acid-binding protein (L-FABP), offer insights into tubular damage. Inflammatory repair-associated biomarkers, interleukin-18 (IL-18), monocyte chemotactic protein-1 (MCP-1), osteopontin (OPN), C-C motif chemokine ligand 14 (CCL14), reflect ongoing recovery Additionally, stress repair markers like tissue inhibitor of metalloproteinase-2 (TIMP-2) insulin-like growth factor-binding protein-7 (IGFBP-7), alongside filtration cystatin C (CysC) proenkephalin (PenKid®) e.tal, further enhance diagnostic precision. Oxidative stress-related Superoxide Dismutase 1 (SOD1), also contribute valuable information. Emerging candidates, microRNAs, soluble urokinase plasminogen activator receptor (SuPAR), chitinase-3-like (CHI3L1), hold substantial promise AKI prognosis. This review summarizes progress in biomarker research, highlighting their clinical utility exploring potential refine management strategies. These findings new perspective integrating routine practice, ultimately care.

Language: Английский

Citations

0
Mode and Mechanism of Action of Omega-3 and Omega-6 Unsaturated Fatty Acids in Chronic Diseases DOI Open Access
Rugen Xu, Adrian Molenaar, Zhi Chen

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1540 - 1540

Published: April 30, 2025

Unsaturated fatty acids, particularly omega-3 and omega-6 polyunsaturated have garnered increasing scientific interest due to their therapeutic potential in chronic disease management. Dietary sources such as milk provide essential unsaturated including linoleic acid α-linolenic acid. Current evidence indicates that these compounds derivatives regulate critical physiological processes, neurodevelopment, visual function, immune modulation, cardiovascular homeostasis. Their multifunctional roles encompass the structural maintenance of biological membranes, cardioprotective effects, anti-inflammatory anti-tumor activities, metabolic regulation. However, despite established associations between acids diseases, mechanistic contributions complex neuropsychiatric disorders remain poorly characterized. Furthermore, controversial role pathogenesis necessitates urgent clarification. This review systematically examines properties, molecular mechanisms, applications diabetes, cancer, dermatological conditions, neurodegenerative disorders, depression. By integrating recent advances dietary science, this work aims address knowledge gaps implications refine evidence-based strategies for intervention through optimized nutritional approaches.

Language: Английский

Citations

0