Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(8), P. 746 - 755
Published: Aug. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
8
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 501 - 501
Published: Feb. 23, 2024
Stroke is a major contributor to global mortality and disability. While reperfusion essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, paradoxical injury primarily caused by oxidative stress, inflammation, blood–brain barrier disruption. An burst inflicts marked cellular damage, ranging from alterations mitochondrial function lipid peroxidation activation of intricate signalling pathways that can even lead cell death. Thus, given pivotal role stress mechanisms reinforcement antioxidant defence system has been proposed as protective approach. Although this strategy proven be successful experimental models, its translation into clinical practice yielded inconsistent results. However, should considered availability numerous molecules with wide range chemical properties affect extent injury; several groups molecules, including polyphenols, carotenoids, vitamins, among other compounds, mitigate damage intervening multiple at various stages. Multiple trials have previously conducted evaluate these using melatonin, acetyl-L-carnitine, chrysanthemum extract, edaravone dexborneol, saffron, coenzyme Q10, oleoylethanolamide, treatments. Therefore, multi-antioxidant therapy emerges promising novel therapeutic option due potential synergistic effect provided simultaneous roles individual compounds.
Language: Английский
Citations
14
JAMA Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Importance Prior research suggests reduced cognitive function after transient ischemic attack (TIA). Whether this is directly related to the TIA, a of preexisting risk factors, or prior decline remains unclear. Objective To study if single, diffusion-weighted image–negative, adjudicated TIA associated with longitudinal declines in cognition, independent factors. Design, Setting, and Participants This was secondary data analysis from Reasons for Geographic Racial Differences Stroke (REGARDS) study, population-based cohort following up 30 239 Black White participants incident cerebrovascular events. The setting consisted telephone assessments. were individuals first-time stroke, asymptomatic community control groups neuroimaging used adjudication. Exposures First-time stroke. Main Outcomes Measures Verbal fluency memory measures administered biannually. Primary outcome composite standardized z score, outcomes individual test performances. Adjusted segmented regression models characterized pre-event postevent cognition annual change. Results Included 356 (mean [SD] age, 66.6 [8.7]; 188 female [53%]) 965 stroke 66.8 [8.2]; 494 male [51%]). A total 14 882 63.2 [8.6] years; 8439 [57%]) included group. Overall before index event lower (−0.25; 95% CI, −0.32 −0.17) than (−0.05; CI: −0.17 0.07; P = .005) (0; −0.03 0.03; < .001) groups. After event, group significantly declined (−0.14; −0.21 −0.07) compared that (0.01; −0.10 0.12; .02) controls (−0.03; −0.05 −0.01; .003). faster ( −0.06 −0.03) (−0.02; −0.02 −0.02) but not different (−0.04; −0.03; .43). Conclusions Relevance suggest despite quick resolution symptoms there apparently sufficient impact be long-term decline. underlying mechanisms are by direct injury and/or interaction concomitant neurodegenerative factors elucidated.
Language: Английский
Citations
1
Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122979 - 122979
Published: Aug. 13, 2024
Language: Английский
Citations
7
Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract The incidence of nerve tissue injuries, such as peripheral injury, spinal cord traumatic brain and various neurodegenerative diseases (NDs), is continuously increasing because stress, physical chemical trauma, the aging population worldwide. Restoration damaged nervous system challenging its structural functional complexity limited regenerative ability. Additionally, there no cure available for NDs except medications that provide symptomatic relief. Stem cells offer an alternative approach promoting damage repair, but their efficacy by a compromised survival rate neurogenesis process. To address these challenges, neural engineering has emerged promising strategy in which stem are seeded or encapsulated within suitable biomaterial construct, cell neurogenesis. Numerous biomaterials utilized to create different types constructs this purpose. Researchers trying develop ideal scaffolds combine biomaterials, cells, molecules exactly mimic biological mechanical properties achieve recovery associated with neurological dysfunction. This review focuses on exploring development applications potential use diagnosis, therapy, regeneration, treatment disorders.
Language: Английский
Citations
4
RSC Advances, Journal Year: 2025, Volume and Issue: 15(2), P. 1052 - 1059
Published: Jan. 1, 2025
The Keap1 (Kelch-like ECH-Associating Protein 1)–Nrf2 (Nuclear Factor Erythroid 2-Related 2)-ARE (Antioxidant Response Element) signaling pathway plays a crucial role in the oxidative stress response and has been linked to development progression of various diseases.
Language: Английский
Citations
0
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
Ischemic stroke is a leading cause of mortality and morbidity globally. Prompt intervention essential for arresting disease progression minimizing central nervous system damage. Although imaging studies play significant role in diagnosing ischemic stroke, their high costs limited sensitivity often result diagnostic treatment delays. Blood biomarkers have shown considerable promise the diagnosis prognosis stroke. Serum markers, closely associated with pathophysiology, aid diagnosis, subtype identification, prediction progression, early neurological deterioration, recurrence. Their advantages are particularly pronounced due to low cost rapid results. Despite identification numerous candidate blood biomarkers, clinical application requires rigorous research thorough validation. This review focuses on various related including coagulation fibrinolysis-related factors, endothelial dysfunction inflammatory neuronal axonal injury exosomes circular RNAs other relevant molecules. It also summarizes latest methods techniques biomarker detection, aiming provide critical references key biomarkers.
Language: Английский
Citations
0
Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Collateral blood vessels are unique, naturally occurring endogenous bypass that provide alternative pathways for oxygen delivery in obstructive arterial conditions and diseases. Surprisingly however, the capacity of collateral circulation to protection varies greatly among individuals, resulting a significant fraction having poor their tissues. We recently reviewed evidence presence naturally-occurring polymorphisms genes determine number diameter collaterals form during development (ie, genetic background), is major contributor this variation. The purpose review summarize current understanding other determinants flow, drawing on both animal human studies. These include level smooth muscle tone collaterals, hemodynamic forces, how (collaterogenesis), de novo formation additional new adulthood, loss with aging cardiovascular risk factor (rarefaction), remodeling (structural lumen enlargement). also emerging not only ischemic but may serve physiological function healthy individuals. Primary focus studies conducted brain, however relevant findings tissues reviewed, as questions future investigation.
Language: Английский
Citations
0
Antioxidants and Redox Signaling, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Significance: Damage after stroke is not only limited to the brain but also often occurs in remote organs, including heart, lung, liver, kidney, digestive tract, and spleen, which are frequently affected by complex pathophysiological changes. The organs human body closely connected, signals transmitted through various molecular substances could regulate changes of organs. Recent Advances: latest studies have shown that inflammatory response plays an important role organ damage stroke, can aggravate activating oxidative stress, sympathetic axis, hypothalamic disturbing immunological homeostasis. Remote cause brain, aggravating damage. Critical Issues: Therefore, in-depth exploration mechanisms adopting corresponding comprehensive intervention strategies become necessary reduce promote protection. Future Directions: strategy involves multifaceted treatment methods such as inflammation regulation, antioxidants, neural stem cell differentiation. It provides a promising alternative for recovery patients inspiration future research treatment. interconnected at level. Only levels we save protect greatest extent. Antioxid. Redox Signal. 00, 000-000.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 559 - 559
Published: April 8, 2025
Rare diseases typically evade the application of standard drug discovery and development pipelines due to their understudied molecular etiology small market size. Herein, we report a rare disease-directed workflow that rapidly studies features disorder, establishes high-throughput screening (HTS) platform, conducts an HTS thousands approved drugs identify validate repositioning candidates. This study examines pediatric neurological disorder caused by de novo mutations in YWHAG, gene encoding scaffolding protein 14-3-3γ, discovers nuclear relocalization severe drop 14-3-3γ binding its phosphorylated partners as key pathogenic hotspot YWHAG mutations. We further established robust vitro platform screened ca. 3000 candidates restore deficient 14-3-3γ-phosphotarget interactions. Our can be applied other 14-3-3-related disorders upscaled for many diseases.
Language: Английский
Citations
0