Simultaneous assessment of mitochondrial and vascular function using the Flow Mediated Skin Fluorescence technique DOI Creative Commons
Andrzej Marcinek, Joanna Katarzyńska, Jerzy Gębicki

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Flow Mediated Skin Fluorescence (FMSF) is a new non-invasive diagnostic method for assessing vascular circulation and/or metabolic regulation. The measures stimulation of the in response to post-occlusive reactive hyperemia (PORH). It analyzes dynamical changes NADH fluorescence emitted from skin tissue, providing information on mitochondrial status and intracellular oxygen delivery through circulatory system. Assessment state using FMSF technique based three parameters: flowmotion (FM) under normoxia conditions, hypoxia sensitivity (HS), hyperemic (HRmax). functioning mitochondria can be assessed by analyzing ischemic (IRmax), basal level fluorescence. There close relationship between Despite these interactions, regulatory function monitored separately as well simultaneously technique. Uniquely, this approach delivers both single measurement.

Language: Английский

Simultaneous assessment of mitochondrial and vascular function using the Flow Mediated Skin Fluorescence technique DOI Creative Commons
Andrzej Marcinek, Joanna Katarzyńska, Jerzy Gębicki

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Flow Mediated Skin Fluorescence (FMSF) is a new non-invasive diagnostic method for assessing vascular circulation and/or metabolic regulation. The measures stimulation of the in response to post-occlusive reactive hyperemia (PORH). It analyzes dynamical changes NADH fluorescence emitted from skin tissue, providing information on mitochondrial status and intracellular oxygen delivery through circulatory system. Assessment state using FMSF technique based three parameters: flowmotion (FM) under normoxia conditions, hypoxia sensitivity (HS), hyperemic (HRmax). functioning mitochondria can be assessed by analyzing ischemic (IRmax), basal level fluorescence. There close relationship between Despite these interactions, regulatory function monitored separately as well simultaneously technique. Uniquely, this approach delivers both single measurement.

Language: Английский

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