Current Opinion in Otolaryngology & Head & Neck Surgery,
Journal Year:
2023,
Volume and Issue:
32(1), P. 20 - 27
Published: Nov. 15, 2023
Purpose
of
review
The
upper
and
lower
airways
are
inter-related
despite
serving
different
functions
can
no
longer
be
considered
separately.
Rhinologists
becoming
increasingly
aware
the
role
airway
plays
in
optimizing
outcomes
for
their
patients.
This
highlights
recent
developments
pulmonology
that
impact
rhinologic
conditions.
Recent
findings
unified
concept
now
supports
multidisciplinary
management
respiratory
pathologies.
Biomarkers,
biologics
treatable
traits
have
permitted
development
personalized
precise
treatment
entire
tract.
corticosteroid
stewardship,
introduction
steroid
sparing
agents
diseases
biomarkers,
forces
us
to
more
considerate
with
oral
(OCS)
prescribing
consider
reduction
regimens.
Finally,
current
research
on
climate
change
vaping
will
allow
better
educate
prepare
our
patients
improve
adherence
avoid
exacerbations
maintain
optimal
global
health.
Summary
inter-relatedness
has
encouraged
a
focus
medicine.
More
is
required
precision
medicine
model,
particularly
realm
biomarkers
endotyping.
These
must
also
change,
pollution
toxins
provide
optimum
care
Medical Mycology,
Journal Year:
2025,
Volume and Issue:
63(4)
Published: April 1, 2025
Allergic
bronchopulmonary
aspergillosis
(ABPA)
is
a
significant
complication
in
people
with
cystic
fibrosis
(pwCF),
driven
by
hypersensitivity
to
Aspergillus
fumigatus.
This
study
aimed
identify
factors
associated
the
development
of
ABPA
pwCF,
using
data
from
French
CF
Registry
(FCFR).
We
conducted
multicenter
case-control
utilizing
anonymized
FCFR,
spanning
period
2016
2021.
A
total
312
cases
were
matched
936
controls.
Various
clinical
factors,
including
CFTR
variants,
nutritional
status,
glucose
disorders,
respiratory
function,
chronic
bacterial
colonization,
and
treatments
such
as
antibiotics,
corticosteroids,
antifungals,
analyzed.
Multivariate
analyses
logistic
regression
models
used
associations
ABPA.
PwCF
who
received
more
frequent
intravenous
antibiotics
(OR
=
2.47,
P
.013),
long-term
inhaled
corticosteroids
1.82,
<
.001),
or
antifungals
5.83,
.0001)
exhibited
higher
likelihood
developing
Additionally,
disorders
significantly
1.41,
.03).
In
contrast,
body
mass
index
(BMI
>25
kg/m²)
appeared
be
protective
factor
0.47,
No
observed
lung
Pseudomonas
aeruginosa
colonization.
These
findings
suggest
that
certain
treatments,
particularly
antibiotic
use,
corticosteroid
therapy,
are
pwCF.
Notably,
BMI
may
have
effect.
Further
research
needed
explore
underlying
mechanisms
these
optimize
treatment
strategies
for
CF,
especially
therapies
continue
evolve.
Journal of Allergy and Clinical Immunology Global,
Journal Year:
2024,
Volume and Issue:
3(4), P. 100298 - 100298
Published: July 3, 2024
Allergic
bronchopulmonary
aspergillosis
(ABPA)
is
a
rare
airway
disorder
primarily
affecting
patients
with
asthma
and
cystic
fibrosis.
Persistent
inflammation
brought
on
by
Respirology Case Reports,
Journal Year:
2024,
Volume and Issue:
12(7)
Published: July 1, 2024
Abstract
Allergic
bronchopulmonary
aspergillosis
(ABPA)
is
an
inflammatory
disease
induced
by
exaggerated
immune
responses
to
Aspergillus
species.
Although
ABPA
has
a
high
recurrence
(48%),
its
instances
with
sequential
isolation
of
distinct
species
are
sporadic.
Only
one
case
report
documented
the
metachronous
fumigatus
and
flavus
.
However,
no
reported
cases
involving
three
exist.
Herein,
we
novel
47‐year‐old
Japanese
man
A.
,
terreus
Initially
presenting
symptoms
productive
cough
pulmonary
infiltration,
patient
experienced
two
relapses
following
treatment
oral
prednisolone.
Adjustments
in
therapy,
including
voriconazole
tailored
corticosteroid
regimen,
resulted
significant
improvement
without
relapse
for
over
6
months.
This
highlights
challenges
successful
management
multiple
MAEDICA – a Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
19(2)
Published: June 15, 2024
Different
from
intrabronchial
mucus
accumulation
in
bronchiectasis
caused
by
chronic
inflammation,
mucoid
impactions
are
observed
patients
with
allergic
bronchopulmonary
aspergillosis
(ABPA)
and
bronchial
asthma.
A
62-year-old
man
was
referred
to
our
hospital
for
treatment
of
Five
years
ago,
he
had
a
coronary
stent
insertion
myocardial
infarction
diagnosed
The
suspected
be
related
the
onset
Inhaled
corticosteroid/long-acting
beta
agonist
not
sufficient
control
condition.
He
received
dupilumab,
humanized
anti-human
IL-4/13
receptor
monoclonal
antibody
(biologic
therapy).
Bronchial
disappeared
single
administration
biologic
therapy
there
has
been
no
recurrence
over
year.
Although
very
rare,
we
do
believe
that
information
regarding
asthma
phenotype
this
patient,
indication
method
changes
before
after
dupilumab
will
provide
some
suggestive
on
similar
course
future.
