Mucormycosis,
one
of
the
significant
fungal
illnesses
caused
by
fungus
Mucormycetes,
is
a
rare
and
fatal
disease.
It
found
all
over
environment.
People
with
weakened
immune
systems
are
more
prone
to
get
sick
rapidly,
including
those
diabetes
or
COVID-19
history.
Mucormycosis
can
affect
eyes
quickly
spread
brain
if
it
enters
through
nose,
sinuses,
lungs.
Existing
research
in
medical
domain
shows
that
deep
learning
techniques
promising
solution
for
assisting
practitioners
making
quick
decisions.
This
study
aims
use
transfer
predefined
VGG16
model
create
classifier
distinguish
between
mild
severe
illness
symptoms.
The
neural
network
trained,
validated,
tested
loading
black
dataset.
accuracy
calculated
varying
number
images.
results
show
proposed
gives
an
92%
520
input
Microbiology and Molecular Biology Reviews,
Journal Year:
2024,
Volume and Issue:
88(1)
Published: March 6, 2024
SUMMARY
The
World
Health
Organization
has
established
a
fungal
priority
pathogens
list
that
includes
species
critical
or
highly
important
to
human
health.
Among
them
is
the
order
Mucorales,
group
comprising
at
least
39
responsible
for
life-threatening
infection
known
as
mucormycosis.
Despite
continuous
rise
in
cases
and
poor
prognosis
due
innate
resistance
most
antifungal
drugs
used
clinic,
Mucorales
received
limited
attention,
partly
because
of
difficulties
performing
genetic
manipulations.
COVID-19
pandemic
further
escalated
cases,
with
some
patients
experiencing
COVID-19-associated
mucormycosis,
highlighting
urgent
need
increase
knowledge
about
these
fungi.
This
review
addresses
significant
challenges
treating
disease,
including
delayed
diagnosis,
lack
accurate
global
incidence
estimation,
treatment
options.
Furthermore,
it
focuses
on
recent
discoveries
regarding
mechanisms
genes
involved
development
resistance,
host
defense
response.
Substantial
advancements
have
been
made
identifying
key
invasion
tissue
damage,
receptors
exploited
by
fungus
invade
tissues,
resistance.
expected
pave
way
new
antifungals
combat
In
addition,
we
anticipate
progress
characterizing
biology,
particularly
pathogenesis
possibilities
offered
CRISPR-Cas9
technology
manipulation
previously
intractable
species.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(10), P. 727 - 727
Published: Oct. 19, 2024
Mucormycosis,
an
invasive
fungal
infection
caused
by
members
of
the
order
Mucorales,
often
progresses
fulminantly
if
not
recognized
in
a
timely
manner.
This
comprehensive
review
discusses
latest
developments
diagnostic
approaches
for
mucormycosis,
from
traditional
histopathology
and
culture-based
methods
to
advanced
emerging
techniques
such
as
molecular
assays,
imaging,
serology,
metabolomics.
We
discuss
challenges
diagnosis
mucormycosis
emphasize
importance
rapid
accurate
identification
this
life-threatening
infection.
mBio,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Coinfection
is
defined
as
the
occurrence
of
at
least
two
genetically
distinct
infectious
agents
within
same
host.
Historically,
fungal
infections
have
been
neglected,
leading
to
an
underestimation
their
impact
on
public
health
systems.
However,
coinfections
become
increasingly
prevalent,
emerging
a
significant
global
concern.
This
review
explores
commonly
associated
with
HIV,
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
influenza,
Mycobacterium
tuberculosis,
and
Pseudomonas
species.
These
include
candidiasis,
aspergillosis,
paracoccidioidomycosis,
cryptococcosis,
histoplasmosis,
pneumocystosis,
sporotrichosis,
mucormycosis.
We
discuss
key
local
systemic
mechanisms
that
contribute
these
coinfections.
HIV
infects
CD4+
cells,
causing
immunosuppression,
particularly
impairing
adaptive
immune
response.
The
inflammatory
response
SARS-CoV-2
infection
disrupts
both
pulmonary
homeostasis,
rendering
individuals
more
vulnerable
disseminated
Severe
influenza
promotes
by
triggering
production
pro-inflammatory
cytokines,
which
damage
epithelial-endothelial
barrier
impair
recognition
phagocytosis
cells.
Tuberculosis
can
replace
normal
lung
parenchyma
collagen
tissue,
alterations
in
architecture,
compromising
its
function.
Interaction
between
Aspergillus
during
coinfection
involves
competition
for
iron
availability
deprivation.
Therefore,
specific
interactions
each
underlying
disease
are
detailed
this
review.
In
addition,
we
highlight
risk
factors
coinfections,
pathophysiology,
epidemiology,
challenges
early
diagnosis.
Recognizing
substantial
worldwide
burden
posed
crucial
improve
survival
rates.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(4), P. 429 - 429
Published: Feb. 15, 2024
COVID-19-associated
rhino-orbital
mucormycosis
has
become
a
new
clinical
entity.
This
study’s
aim
was
to
evaluate
the
histopathological
and
ultramicroscopic
morphological
aspects
of
this
fungal
infection.
an
observational
retrospective
study
on
eight
patients
from
three
tertiary
centers
in
Romania.
The
tissue
samples
collected
during
functional
endoscopic
sinus
surgery
were
studied
through
examination,
scanning
electron
microscopy,
transmission
microscopy.
In
characteristic
all
cases
identified:
wide
aseptate
hyphae
with
right-angle
ramifications,
which
invade
blood
vessels.
One
case
presented
perineural
invasion
into
lymphatics.
And
another
case,
mucormycosis–aspergillosis
coinfection
identified.
Through
long
surface
mucosa
surrounded
by
cells
belonging
local
immune
system
identified
samples,
bacterial
biofilms
half
samples.
elements
majority
Rhino-orbital-cerebral
associated
COVID-19
produces
nasal
dysbiosis,
favors
appearance
biofilms.
way
infection
develops
depends
interaction
fungi
system.
Journal of Indian Society of Periodontology,
Journal Year:
2024,
Volume and Issue:
28(4), P. 484 - 488
Published: July 1, 2024
Endodontic-periodontal
(endo-perio)
lesions
are
commonly
encountered
in
dental
clinics,
with
patients
typically
presenting
acute
pulpal
pain,
often
accompanied
by
abscess
formation
and
tooth
mobility.
Management
generally
involves
root
canal
treatment
(RCT)
and,
if
required,
surgical
intervention.
This
article
discusses
a
notable
case
of
43-year-old
male
patient
who
presented
chief
complaint
pain
loose
teeth
the
upper
left
back
region
for
past
3
weeks.
Phase
I
periodontal
therapy
was
initiated,
followed
RCT
#21
to
#25.
However,
2
weeks
later,
swelling,
prompting
excision
biopsy.
Histopathological
analysis
revealed
nonseptate
hyphae
right-angle
branching,
indicative
mucormycosis.
WORLD JOURNAL OF PLASTIC SURGERY,
Journal Year:
2023,
Volume and Issue:
12(3), P. 64 - 72
Published: Oct. 1, 2023
Evaluation
of
Clinical
Manifestations,
Pattern
Involvement,
and
Surgical
Outcomes
in
Patients
with
Post
Covid-19
Head
Neck
Mucormycosis
Infection
among
Admitted
To
Namazi
Hospital,
Shiraz,
Iran
(2021-2022)
DMW - Deutsche Medizinische Wochenschrift,
Journal Year:
2024,
Volume and Issue:
149(10), P. 569 - 578
Published: April 24, 2024
The
first
patients
positive
for
SARS-CoV-2
were
registered
in
December
2019.
In
March
2020,
the
World
Health
Organization
(WHO)
declared
COVID-19
outbreak
a
global
pandemic,
beginning
of
worldwide
health
crisis
that
revealed
numerous
medical
challenges
healthcare
systems
and
pandemic
emergency
strategies.Among
these
challenges,
mucormycosis,
typically
rare
fungal
infection,
gained
attention.
With
an
average
incidence
about
2
per
1
million
people,
mucormycosis
is
considered
very
disease,
opportunistic
infection
mostly
affecting
lungs
or
skin
soft
tissues
immunocompromised
patients.
Poorly
controlled
diabetes
mellitus
one
leading
risk
factors
rhino-orbital
mucormycosis.
Countries
with
high
prevalence
limited
resources
have
higher
rates,
India
Pakistan
being
among
nations
particularly
incidences.During
second
wave
India,
rates
surged
dramatically
within
few
weeks,
over
47,500
cases
COVID-19-associated
(CAM)
reported
between
May
August
2021.
Mucormycosis
characterized
by
mortality
rate
up
to
90%,
especially
when
diagnosis
delayed,
treatment
commences
late.
There
concerns
potentially
threat.In
this
article,
we
explore
mechanisms
viral-fungal
coinfection.
We
present
distribution
patterns,
clinical
presentation,
