Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer DOI Creative Commons

Neha Rawat,

Nabeel Ahmad,

Pratishtha Raturi

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 20, 2023

The initiation of the "nanotechnology era" within past decade has been prominently marked by advancements in biomaterials. This intersection opened up numerous possibilities for enhancing detection, diagnosis, and treatment various illnesses leveraging synergy between biomaterials nanotechnology. term "nano biomaterials" referring to featuring constituent or surface feature sizes below 100 nm, presents a realm extraordinary materials endowed with unique structures properties. Beyond addressing common biomedical challenges, these nano contribute unprecedented insights principles that enrich our understanding biology, medicine, science. A critical evaluation recent technological progress employing medicine is essential, along an exploration potential future trends. Nanotechnology breakthroughs have yielded novel surfaces, materials, configurations notable applications domain. integration nanotechnology already begun enhance traditional practices across diverse fields such as tissue engineering, intelligent systems, utilization nanocomposites implant design, controlled release biosensors, more. mini review encapsulates into biomaterials, encompassing their types, synthesis methods, roles organic inorganic nanoparticles, elucidating mechanisms action. Furthermore, focus squarely placed on versatile applications, particular emphasis anticancer antimicrobial interventions. underscores dynamic landscape nanotechnology, envisioning where play pivotal role advancing medical particularly combating cancer microbial infections.

Language: Английский

Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector DOI Creative Commons
Saroj Bala, Diksha Garg, Kandi Sridhar

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(2), P. 152 - 152

Published: Jan. 23, 2023

The agricultural sector generates a significant amount of waste, the majority which is not productively used and becoming danger to both world health environment. Because promising relevance agro-residues in agri-food-pharma sectors, various bioproducts novel biologically active molecules are produced through valorization techniques. Valorization agro-wastes involves physical, chemical, biological, including green, pretreatment methods. Bioactives development from has been widely researched recent years. Nanocapsules now increase efficacy bioactive food applications. This review addresses agri-waste methods, value-added bioproducts, recovery compounds, their uses. Moreover, it also covers present status micro- nanoencapsulation strategies

Language: Английский

Citations

110
Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies DOI Creative Commons

Hanchao Lin,

Yixin Yu,

Zhu Le

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 59, P. 102601 - 102601

Published: Jan. 7, 2023

Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.

Language: Английский

Citations

65
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges DOI Creative Commons
Tatiana Andreani, Ruoyu Cheng, Khalil Elbadri

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916

Published: July 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Language: Английский

Citations

22
A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research DOI
Bárbara B. Mendes, Zilu Zhang, João Conniot

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(6), P. 867 - 878

Published: May 15, 2024

Language: Английский

Citations

17
Advances and significances of gold nanoparticles in cancer treatment: A comprehensive review DOI Creative Commons
Amran Hossain,

Md. Thohid Rayhan,

Md Hosne Mobarak

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 101559 - 101559

Published: May 24, 2024

This comprehensive review examines the diverse range of uses gold nanoparticles across numerous disciplines, focusing on their distinctive characteristics in catalysis, thermal conductivity, optical properties, electrical and biological interactions. work emphasizes crucial significance progression cancer treatment, demonstrating multifunctionality areas drug transport, photothermal therapy, bioimaging, diagnostic applications. Gold have demonstrated utility improving accuracy effectiveness treatments, presenting innovative approaches to address clinical obstacles. Nevertheless, research also discusses notable challenges, including apprehensions over toxicity, influence nanoparticle size, potential environmental repercussions. These issues emphasize necessity responsible administration fully exploit capabilities context therapy. Notwithstanding these obstacles, ultimately underscores profound domains such as monitoring, renewable energy, healthcare, cosmetics, biotechnology. highlights capacity mold future through inventive adaptable means

Language: Английский

Citations

15
Dysprosium doped SrCeO3 nanophosphors for advanced photochemical applications: Synthesis, characterization, photo-assisted dye degradation and latent fingerprint visualization DOI

Sanjay S. Majani,

R.B. Basavaraj,

Muzaffar Iqbal

et al.

Materials Science in Semiconductor Processing, Journal Year: 2024, Volume and Issue: 182, P. 108674 - 108674

Published: July 6, 2024

Language: Английский

Citations

9
Development of a versatile biomaterial of chitosan polymer/ginger (Zingiber officinale Roscoe) extract/ZnO bionanocomposite: physicochemical properties, antioxidant activity, and breast cancer therapy DOI

Muthanna O. Hussein,

Ahmed Saud Abdulhameed

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

1
Nanomedicine to Overcome Antimicrobial Resistance: Challenges and Prospects DOI
Wei Zou,

Alyssa McAdorey,

Hongbin Yan

et al.

Nanomedicine, Journal Year: 2023, Volume and Issue: 18(5), P. 471 - 484

Published: Feb. 1, 2023

Translation of antibacterial nanoparticles into nanomedicine requires a deep understanding the dynamic nature and ways they overcome immunological biological barriers. Nanomedicines need prolonged serum stability by proper stealth coating or forming beneficial protein corona, to avoid rapid clearance mononuclear phagocytic system. A preferred nanoparticle formulation may include nonimmunogenic carbohydrates, which act both as ligands specific endothelium receptors facilitate nanomedicines crossing vascular barrier. This lead more delivery accumulation at infection site provide broader faster clinical responses than targeting bacterial surface receptors. Ideally, should be able penetrate biofilms through fusion and/or diffusion for targeted delivery.

Language: Английский

Citations

21
Silver nanoparticles in diabetes mellitus: therapeutic potential and mechanistic insights DOI Creative Commons
Susanta Paul,

Ishita Sarkar,

Nilanjan Sarkar

et al.

Bulletin of the National Research Centre/Bulletin of the National Research Center, Journal Year: 2024, Volume and Issue: 48(1)

Published: March 21, 2024

Abstract Background Research on the use of silver nanoparticles in context diabetes mellitus has gained attention due to unique properties these nanoparticles, such as their antimicrobial, anti-inflammatory, and antioxidant characteristics. While field is still its early stages, several studies have explored potential applications effects managing diabetes. Main body abstract Diabetes mellitus, a global health concern marked by impaired insulin function high blood glucose levels, spurred innovative therapeutic investigations, including nanotechnology. Silver emerged promising candidates this pursuit. This provides an overview current research nanoparticles’ application highlighting mechanisms action. With physicochemical like surface area bio-compatibility, are ideal for diverse biomedical applications. Recent show ability modulate key pathways pathogenesis, enhancing sensitivity, reducing oxidative stress, supporting pancreatic beta-cell function. Their antimicrobial particularly beneficial patients prone infections. Moreover, using nanoparticle-based carriers anti-diabetic drugs improves drug bio-availability reduces side effects, potentially conventional medication efficacy. However, addressing safety toxicity concerns crucial. Ongoing focuses optimizing nanoparticle size, shape, modifications enhance bio-compatibility minimize adverse effects. Short conclusion In conclusion, represent novel multifaceted approach management mellitus. target multiple facets resistance, inflammation, positions them future interventions. further warranted elucidate long-term profile optimize clinical settings.

Language: Английский

Citations

8
Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments DOI Creative Commons
Konstantinos Avgoustakis, Athina Angelopoulou

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 179 - 179

Published: Jan. 26, 2024

Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays crucial role in the clinical therapeutic outcome conventional treatments innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering challenges tumor microenvironment (TME), respect effective drug accumulation activity at site. The main focus is overcome obstacles abnormal vasculature, dense stroma, extracellular matrix, hypoxia, pH gradient acidosis. In this endeavor, nanomedicines that targeting distinct features TME flourished; these aim increase site specificity achieve deep penetration. Recently, research focused on immune reprograming order promote suppression cancer stem cells prevention metastasis. Thereby, several nanomedicine therapeutics which shown promise preclinical studies entered trials or already practice. Various novel strategies were employed trials. Among them, based biomaterials show improving efficacy, reducing side effects, promoting synergistic for responsive targeting. review, we mechanisms response solid tumors. We describe take advantage biomaterials’ properties exploit posed by TME. development such systems has significantly advanced application combinational therapies immunotherapies improved anticancer effectiveness.

Language: Английский

Citations

6