A Wireless Millimeter‐Scale Device for in Vivo Electromagnetic Brain Tumor Therapy by Ultrasound‐Responsive Ti3C2Tx Hydrogel DOI

Jiahao He,

Jie Li,

Jinliang Ren

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Implantable devices that integrate advanced nanomaterials with wireless energy systems represent a transformative approach to tackling brain tumors. Here, millimeter‐scale implantable device based on an MXene/polyvinyl alcohol (PVA) hydrogel is introduced, designed for precise and minimally invasive tumor therapy via tunable alternating electric fields. This presents novel by combining ultrasonic transfer triboelectric harvesting, eliminating the need in vivo batteries enabling continuous operation completely manner. The system not only optimizes harvesting efficiency but also ensures localized delivery of therapeutic fields directly site. Its compact size mechanical flexibility allow implantation complex environment, offering solution enhanced safety adaptability. Preclinical evaluations using U‐87 MG orthotopic glioblastoma models demonstrate significant growth inhibition marked improvement survival rates, underscoring its potential.

Language: Английский

A Wireless Millimeter‐Scale Device for in Vivo Electromagnetic Brain Tumor Therapy by Ultrasound‐Responsive Ti3C2Tx Hydrogel DOI

Jiahao He,

Jie Li,

Jinliang Ren

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Implantable devices that integrate advanced nanomaterials with wireless energy systems represent a transformative approach to tackling brain tumors. Here, millimeter‐scale implantable device based on an MXene/polyvinyl alcohol (PVA) hydrogel is introduced, designed for precise and minimally invasive tumor therapy via tunable alternating electric fields. This presents novel by combining ultrasonic transfer triboelectric harvesting, eliminating the need in vivo batteries enabling continuous operation completely manner. The system not only optimizes harvesting efficiency but also ensures localized delivery of therapeutic fields directly site. Its compact size mechanical flexibility allow implantation complex environment, offering solution enhanced safety adaptability. Preclinical evaluations using U‐87 MG orthotopic glioblastoma models demonstrate significant growth inhibition marked improvement survival rates, underscoring its potential.

Language: Английский

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