Measuring Physical and Chemical Properties of Single Nanofibers for Energy Applications—Possibilities and Limits DOI Creative Commons
Tomasz Bƚachowicz, Nonsikelelo Sheron Mpofu, Andrea Ehrmann

et al.

Nanoenergy Advances, Journal Year: 2024, Volume and Issue: 4(4), P. 300 - 317

Published: Oct. 9, 2024

Nanofibers can be produced by various techniques, such as a broad range of electrospinning techniques to produce nanofiber mats from different polymers or polymer blends, often filled with metallic semiconducting nanoparticles nanotechnological bottom-up top-down methods. They are important parts wide variety energy applications, batteries, fuel cells, photovoltaics, hydrogen storage materials. Usually, their physical chemical parameters measured averaging over fiber bundle part mat. Here, we report the possibility measuring and properties single nanofibers nanowires. Such measurements more complicated than investigations bundles whole and, thus, less found in literature. After fast increase between 2001 2009, numbers respective studies now stagnating. This review thus aims make possibilities visible broader scientific audience providing several examples based on atomic force microscopy (AFM) other broadly available techniques. The focus this is technologies that reveal information pure surface morphology nanowires, mechanical wettability, porosity, electrical conductivity.

Language: Английский

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery DOI
Deng‐Guang Yu,

Wenjian Gong,

Jianfeng Zhou

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

Citations

63

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery DOI Creative Commons
Hai-Rong Mao, Jianfeng Zhou,

Liang Yan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 13, 2024

Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.

Language: Английский

Citations

31

Ionogels as advanced materials for overcoming challenges in wound healing and drug delivery DOI Creative Commons
Augusto Q. Pedro, Leonor S. Castro, João A. P. Coutinho

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Despite relevant advances, the pharmaceutical industry continues to strive with limited adaptability, moisture management, and discomfort caused by existing wound dressings. Adding these challenges are bioavailability pharmacokinetics of common (bio)therapeutics, overall leading unmet clinical demands, safety concerns, poor patient compliance. Ionogels, a versatile class materials comprising ionic liquids (ILs) confined in an organic or inorganic solid network, have been proposed overcome drawbacks. They demonstrated ability enhance antimicrobial mechanical properties resulting while allowing remarkable improvements drug solubility their delivery targeted sites. Nowadays, investigations trials still required fully leverage potential ionogels for human applications. However, recent FDA approval New Drug Application MRX-5LBT®, transdermal system, opens promising perspectives toward translation ionogels. This review focuses on advances achieved design applications, viz. topical formulations promote healing activity, as platforms improve (solubility bioavailability), at specific sites controlled release behaviour.

Language: Английский

Citations

6

Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management DOI Creative Commons
Fang Wang,

Wenqing He,

Bing Dai

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The management of wound exudate is vital importance for healing. Exudate accumulation around prolongs inflammation and hinders Although traditional dressings can absorb exudate, they are unable to drain in time, often resulting a poor feature with In recent years, the appearance asymmetric wettability has shown great potential management. Here, we summarize latest progress 3 kinds management, including Janus structure, sandwich gradient structure. most common structural dressing among highlighted from 2 aspects: single-layer modified structure double-layer challenges faced by discussed, developing trends smart this field prospected.

Language: Английский

Citations

0

Bioinspired nanofiber dressings with counter-transport of exudate and drug for treating heavily exuding wounds DOI

Xuening Jin,

Yan Wu, Zizhao Chen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123115 - 123115

Published: Jan. 21, 2025

Language: Английский

Citations

0

Designing of electrospun unidirectional water transport nanofiber membranes: mechanisms, structures, and applications DOI
Lei Li, Xinyue Yang, Weimin Kang

et al.

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128221 - 128221

Published: March 1, 2025

Language: Английский

Citations

0

Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing DOI

Fateme Sanati,

Mansoureh Ashghali Farahani, Mohammad Reza Rostami‐Darounkola

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: March 13, 2025

Nowadays, extensive research has been conducted on electrospun nanofibers for wound dressing applications. Considering the growing concern over bacterial resistance to common antibiotics, investigating potential of natural essential oils with antibacterial properties could prove be beneficial in addressing this issue. In response challenges posed by impaired healing, we have designed a novel polyvinyl alcohol/chitosan nanofiber embedded myrtle oil and gum Arabic dispersion (PVA/CS/MT-GA). The morphology molecular structure prepared were evaluated scanning electron microscopy (SEM) Fourier transform infrared (FTIR) analysis. synthesized PVA/CS/MT-GA composite demonstrated remarkable swelling capacity 744% exhibited acceptable mechanical strength. Additionally, water vapor transmission rate (WVTR) these was obtained as 2497 g.m−2.day−1, which falls within ideal range dressings. antimicrobial test results revealed that notable when tested against Escherichia coli Staphylococcus aureus. release profile MT from MT-containing burst mechanism nanofibers, can applications require an immediate therapeutic effect. Furthermore, dressings full-thickness model Wistar rats care damaged tissue promote faster healing times. Collectively, study suggest developed holds great promise candidate

Language: Английский

Citations

0

Nanohydroxyapatite and liposomes-coated integral bilayer scaffold for osteochondral repair via mimicking the dual differentiation microenvironment of BMSCs DOI Creative Commons
Weikang Zhao,

Biemin Sun,

Yu Song

et al.

Nano Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0

Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: in vitro and in vivo assay DOI

Moosa Hatami,

Mohammad Taghi Khorasani, Ebrahim Ahmadi

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: April 17, 2025

Although the skin has a high healing capacity, severe wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for healing. This study focuses on integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) prepare ternary composite (PVP/QCS/DEX) as dressing hydrogels with varying concentration PVP DEX. A variety analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, water vapor transmission rate (WVTR) were employed assess characteristics samples. The uniform interconnected porous structure samples was confirmed by SEM results. All showed porosity transition rate, demonstrating their ability provide suitable moist environment efficient exudate handling antibacterial test conducted demonstrated activity drug-loaded hydrogel Escherichia coli Staphylococcus aureus. in vitro cytotoxicity evaluation using MTT assay that developed PVP/QCS/DEX exhibit satisfactory cytocompatibility promote cell viability. results scratch indicated had promoted migration would improve accelerate process. vivo tests sample revealed promising performance. Therefore, based favorable performance observed throughout analysis, as-prepared show promise field dressings.

Language: Английский

Citations

0

Antibacterial and wound healing activity of non-thermal plasma treated and MXene (Ti3C2TX)/ WO3 coated cotton fabrics DOI

Udaya Vaka,

M.C. Ramkumar

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown, P. 130072 - 130072

Published: Oct. 1, 2024

Language: Английский

Citations

2