First investigation survey on the pristine C3N3 and B3O3 monolayer as a promising vehicle for delivery of 5-fluorouracil and cisplatin anticancer drugs

Chinese Journal of Physics, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10174 - 10174

Published: Sept. 22, 2024

This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides proteins. GO, a versatile nanomaterial oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity environmental impact. Peptides proteins can be functionalized GO surfaces through various methods, including non-covalent such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, van der Waals well covalent bonding reactions involving amide bond formation, esterification, thiol chemistry, click chemistry. These approaches enhance GO’s functionality several key areas: biosensing sensitive biomarker detection, theranostic imaging that integrates diagnostics therapy real-time treatment monitoring, targeted cancer where deliver drugs directly tumor sites while being tracked by techniques like MRI photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering aiding tissues’ bone, muscle, nerve regeneration, their antimicrobial properties improving infection-resistant medical devices. Despite potential, addressing stability scalability is essential fully harness benefits GBMs healthcare.

Language: Английский

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Evaluation of Drug Delivery Systems Based on Host–guest Interactions Between Pure/Metal‐doped BN Nanotubes with Oteracil and Potassium Oteracil Anticancer Drugs

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(4)

Published: Jan. 1, 2025

Abstract The aim of this project is to investigate host–guest complexes based on pure and doped‐BN nanotubes for the treatment gastric gastrointestinal cancer. Therefore, in work, obtained from interaction boron nitride (BNNTs) as well Al Ga‐doped BN with anticancer drugs Oteracil (OT) potassium oteracil (OTP) were investigated gas phase water solvent. All calculations performed at M06‐2X/6–31G(d) level theory. Interaction energies, structural parameters, topological properties RDG, ELF, CCD analyses used assess strength interactions complexes. results show that have stronger OT OTP drugs. Adsorption energies (ΔEads) reveal adsorption tendency order BN(Ga) > BN(Al) pure‐BN. electronic compared before after process. quantum molecular descriptors reactivity energy gap (Eg) was dramatically changed when dopant atoms added nanotube. impurity can improve type be physical. Increasing temperature reduces recovery time. Analysis natural bond orbital (NBO), electrostatic potential surface maps (MESP), (RDG) evaluate nature drug/nanotube intermolecular interactions. Generally, absorb higher than nanotubes. This study provide insights into innovation design drug delivery systems.

Language: Английский

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A Novel Al8N8 and B8N8 Nanoring Monolayer for Sensing and Drug Delivery of Cisplatin and Nitrosourea Anticancer Drugs: A DFT Insight

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

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Adsorption Characteristics of the Anticancer Drug Hydroxyurea with Armchair BN Graphene Nanoribbons Containing and Lacking Vacancy Defects: Insight via DFT Calculations

Journal of Superconductivity and Novel Magnetism, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Language: Английский

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