Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107641 - 107641

Published: Feb. 1, 2025

Language: Английский

Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution

Language: Английский

Antimicrobial hydrogel scaffolds from Barba de Viejo microfibers, alginate and ag nanoparticles via green synthesis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138048 - 138048

Published: Nov. 1, 2024

Language: Английский