Aptamer-based rapid diagnosis for point-of-care application

Microfluidics and Nanofluidics, Journal Year: 2023, Volume and Issue: 27(2)

Published: Jan. 18, 2023

Language: Английский

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On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5632 - 5643

Published: March 13, 2023

The development of in vivo, longitudinal, real-time monitoring devices is an essential step toward continuous, precision health monitoring. Molecularly imprinted polymers (MIPs) are popular sensor capture agents that more robust than antibodies and have been used for sensors, drug delivery, affinity separations, assays, solid-phase extraction. However, MIP sensors typically limited to one-time use due their high binding (>107 M–1) slow-release kinetics (<10–4 μM/sec). To overcome this challenge, current research has focused on stimuli-responsive MIPs (SR-MIPs), which undergo a conformational change induced by external stimuli reverse molecular binding, requiring additional chemicals or outside stimuli. Here, we demonstrate fully reversible based electrostatic repulsion. Once the target analyte bound within thin film electrode, small electrical potential successfully releases molecules, enabling repeated, accurate measurements. We electrostatically refreshed dopamine with 760 pM limit detection, linear response profile, accuracy even after 30 sensing–release cycles. These could repeatedly detect <1 nM released from PC-12 cells vitro, demonstrating they can longitudinally measure low concentrations complex biological environments without clogging. Our work provides simple effective strategy enhancing MIPs-based biosensors all charged molecules other sensing applications.

Language: Английский

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An Overview of Flexible Sensors: Development, Application, and Challenges

Sensors, Journal Year: 2023, Volume and Issue: 23(2), P. 817 - 817

Published: Jan. 10, 2023

The emergence and advancement of flexible electronics have great potential to lead development trends in many fields, such as “smart electronic skin” wearable electronics. By acting intermediates detect a variety external stimuli or physiological parameters, sensors are regarded core component systems been extensively studied. Unlike conventional rigid requiring costly instruments complicated fabrication processes, can be manufactured by simple procedures with excellent production efficiency, reliable output performance, superior adaptability the irregular surface surroundings where they applied. Here, recent studies on for sensing humidity strain/pressure outlined, emphasizing their sensory materials, working mechanisms, structures, methods, particular applications. Furthermore, conclusion, including future perspectives short overview market share this field, is given further advancing field research.

Language: Английский

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Recent advances in point-of-care testing of COVID-19

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(24), P. 8500 - 8530

Published: Jan. 1, 2023

This review explores various point-of-care optical diagnostic systems combined with microdevices developed during the recent COVID-19 pandemic for clinical diagnostics.

Language: Английский

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Applications of metal organic frameworks in point of care testing

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 172, P. 117596 - 117596

Published: Feb. 8, 2024

Diagnostic devices used in the point-of-care (POC) today play a critical role as tools to provide essential medical surveillance data and ensure that patients receive appropriate timely care. These also allow self-analysis by patient, increasing therapeutic adherence well reducing pressure on clinical structures. The development of new diagnostic tools, therefore, represents significant challenge from technological point view, both terms overcoming current weaknesses costs, accuracy, performance, an analytical view order develop are operator-independent possible. Recent breakthroughs technologies (such cell phone-dependent technologies, paper-based procedures, lab-on-a-chip devices) paving way for next generation testing (POCT). Innovative assay devices, efficient reagent storage techniques, required POCT technologies. Nanomaterials different forms, sizes, compositions, such carbon nanomaterials, quantum dots, gold silver nanoparticles, mesoporous silica metal-organic frameworks (MOFs), have been created characterized recent years. Due their specific physicochemical properties, MOF nanoparticles increasingly being improve performance simplify techniques. MOFs colorimetric or electrochemical carriers plasmonic biosensors be resistant environmental conditions. This review will discuss detailed 2016 2023, addition chemical synthesis characterization methods related uses applications MOF.

Language: Английский

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Colorimetric sensing for translational applications: from colorants to mechanisms

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7681 - 7741

Published: Jan. 1, 2024

This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.

Language: Английский

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Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges

Sensors, Journal Year: 2024, Volume and Issue: 24(16), P. 5143 - 5143

Published: Aug. 8, 2024

This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection therapeutic drug monitoring. It provides an in-depth analysis various types applications, including enzymatic sensors, immunosensors, DNA elucidating mechanisms specific healthcare applications. The highlights recent innovations such as integrating nanotechnology, developing wearable devices, trends miniaturisation, showcasing transformative potential healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, data security challenges, proposing strategic solutions to overcome these obstacles. is envisaged that will inform decision-making, drive technological innovation, enhance global outcomes by synthesising multidisciplinary insights.

Language: Английский

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Artificial Intelligence in Point-of-Care Biosensing: Challenges and Opportunities

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1100 - 1100

Published: May 25, 2024

The integration of artificial intelligence (AI) into point-of-care (POC) biosensing has the potential to revolutionize diagnostic methodologies by offering rapid, accurate, and accessible health assessment directly at patient level. This review paper explores transformative impact AI technologies on POC biosensing, emphasizing recent computational advancements, ongoing challenges, future prospects in field. We provide an overview core their use POC, highlighting issues challenges that may be solved with AI. follow can applied including machine learning algorithms, neural networks, data processing frameworks facilitate real-time analytical decision-making. explore applications each stage biosensor development process, diverse opportunities beyond simple analysis procedures. include a thorough outstanding field AI-assisted focusing technical ethical regarding widespread adoption these technologies, such as security, algorithmic bias, regulatory compliance. Through this review, we aim emphasize role advancing inform researchers, clinicians, policymakers about reshaping global healthcare landscapes.

Language: Английский

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Metal-based nanomaterials with enzyme-like characteristics for bacterial rapid detection and control

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215799 - 215799

Published: April 1, 2024

Language: Английский

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Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics

Biosensors, Journal Year: 2024, Volume and Issue: 14(2), P. 71 - 71

Published: Jan. 30, 2024

Early-stage detection and diagnosis of diseases is essential to the prompt commencement treatment regimens, curbing spread disease, improving human health. Thus, accurate disease biomarkers through development robust, sensitive, selective diagnostic tools has remained cutting-edge scientific research for decades. Due their merits being selective, stable, simple, having a low preparation cost, molecularly imprinted polymers (MIPs) are increasingly becoming artificial substitutes natural receptors in design state-of-the-art sensing devices. While there different MIP approaches, electrochemical synthesis presents unique outstanding method chemical applications, allowing direct formation polymer on transducer as well simplicity tuning film properties, thus accelerating trend commercial MIP-based sensors. This review evaluates recent achievements applications electrosynthesized sensors clinical analysis biomarkers, identifying major trends highlighting interesting perspectives realization MIP-endowed testing devices rapid determination prevailing diseases.

Language: Английский

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