Biomimetic nanoparticles with cell-membrane camouflage for rheumatoid arthritis DOI Creative Commons
Jingjing Gan, Danqing Huang,

Junyi Che

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 794 - 825

Published: Jan. 15, 2024

Language: Английский

A Novel Activatable Nanoradiosensitizer for Second Near‐Infrared Fluorescence Imaging‐Guided Safe‐Dose Synergetic Chemo‐Radiotherapy of Rheumatoid Arthritis DOI Creative Commons

Yarong Jin,

Dongsheng Li,

Xiaochun Zheng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 28, 2024

Abstract The precise theranostics of rheumatoid arthritis (RA) remains a formidable challenge in clinical practice. Exploring novel applications contemporary therapeutic approaches like chemo‐radiotherapy is promising as highly effective strategy for RA. Herein, activatable nanoradiosensitizer‐40 (denoted IRnR‐40) developed, based on encapsulating the clinically approved drugs cisplatin (DDP) and indocyanine green (ICG) within gelatin shell to achieve second near‐infrared fluorescence (NIR‐II FL) imaging‐guided safe‐dose synergetic chemo‐radiotherapy. high concentration matrix metalloproteinase‐9 (MMP‐9) RA microenvironment plays pivotal role triggering responsive degradation IRnR‐40, leading rapid release functional molecules DDP ICG. released ICG serves dual purpose illuminating inflamed joints facilitate accurate target volume delineation guiding radiotherapy, well acting real‐time reporter quantifying monitor efficacy. Meanwhile, achieves synergistic chemotherapy radiosensitization via reactive oxygen species (ROS)‐mediated mitochondrial apoptotic pathway. To sum up, this nanoradiosensitizer IRnR‐40 believed be first attempt efficient NIR‐II FL RA, which provides new paradigm refractory benign diseases.

Language: Английский

Citations

11
Regulation of rheumatoid arthritis microenvironment via a self-healing injectable hydrogel for improved inflammation elimination and bone repair DOI Creative Commons

Wenbo Geng,

Jie Zhao, Bailong Tao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 287 - 300

Published: March 8, 2024

The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop dual-gas-mediated injectable hydrogel for modulating immune RA simultaneously releasing therapeutic drugs. (DNRS gel) could be broken down on-demand consuming excessive nitric oxide (NO) hydrogen sulfide (H

Language: Английский

Citations

10
Inflammatory macrophage reprogramming strategy of fucoidan microneedles-mediated ROS-responsive polymers for rheumatoid arthritis DOI
Xiaowei Liu,

Ningning Diao,

Shiqing Song

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132442 - 132442

Published: May 16, 2024

Language: Английский

Citations

10
Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment DOI

Yasi Deng,

Hao Zheng, Bin Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 498 - 515

Published: June 12, 2024

Language: Английский

Citations

10
Biomimetic nanoparticles with cell-membrane camouflage for rheumatoid arthritis DOI Creative Commons
Jingjing Gan, Danqing Huang,

Junyi Che

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 794 - 825

Published: Jan. 15, 2024

Language: Английский

Citations

9