Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
Abstract
Non‐thermal
bioelectricity
cancer
therapy
(BECT),
utilizing
high‐voltage
and
high‐frequency
pulsed
electric
fields,
represents
a
novel
approach
in
oncological
treatment.
Herein,
an
pulse‐regulated
MXene‐based
nanozyme
(MXenzyme)‐catalyzed
cell
eradication
is
presented
while
activating
immunogenic
responses
for
integrative
BECT
immunotherapy.
Ti₃C₂
MXenzyme,
the
most
conductive
member
of
MXene
family,
synthesized
characterized
superior
electrical
properties
aqueous
environment.
Incorporating
MXenzyme
into
significantly
enhances
irreversible
death
expands
ablation
area
compared
to
alone.
Computational
modeling
reveals
that
on
membranes
generates
localized
hotspots
current
density
field
(E‐field)
concentration
during
application.
catalytic
effect
induced
three
primary
cytotoxic
mechanisms:
1)
direct
membrane
depolarization
poration,
2)
disruption
voltage‐gated
ion
channels,
3)
generation
reactive
oxygen
species.
These
combined
mechanisms
contributed
death.
Immunological
profiling
tumor
microenvironment
modulated
by
MXenzyme‐BECT
confirmed
its
profound
impact
activation
potent
anti‐tumor
immune
response.
Translational
potential
evaluated
using
computational
modeling‐based
pre‐treatment
planning
combination
with
checkpoint
inhibitor
therapy.
Findings
underscore
MXenzyme's
pivotal
role
as
highly
electric‐regulated
enzymatic
catalyst,
enhancing
efficacy
advancing
BECT‐immunotherapy
strategies.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Abstract
Catalytic
medicine,
using
enzymes
or
nanozymes,
is
an
emerging
method
for
cancer
treatment.
However,
its
applicability
limited
by
the
low
catalytic
activity
in
tumor
microenvironment
(TME).
In
this
work,
a
versatile
and
synthesis‐friendly
nanozyme,
CeO
2
Mn
1.08
O
x
nanoclusters,
prepared.
This
novel
Ce─Mn
heterojunction
formed
oxidation
of
nanoparticles
through
H
SO
4
/KMnO
.
exhibits
high
multi‐enzymatic
activities
acts
as
catalase
(CAT),
peroxidase
(POD),
oxidase
(OXD)
mimics
under
acidic
conditions.
It
can
regulate
TME
relieving
hypoxia
consuming
endogenous
glutathione
(GSH).
Glucose
(GOx)
then
incorporated
into
linked
with
poly(ethylene
glycol)
(PEG)
to
obtain
cascade
enzyme
system
(Ce─Mn)‐PEI/GOx‐PEG.
CAT‐like
properties,
which
sensitize
GOx‐based
starvation
therapy,
POD‐
OXD‐like
generate
highly
cytotoxic
reactive
oxygen
species
(ROS)
cells.
The
glucose
catabolic
product,
,
also
used
ROS.
addition,
structure
provides
near‐infrared
(NIR)
photothermal
capability,
making
it
suitable
therapy
(PTT).
Density
functional
theory
(DFT)
calculations
provide
possible
reasons
capability
When
combining
mild
PTT
(Ce─Mn)‐PEI/GOx‐PEG
efficiently
ablate
tumors.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
importance
of
nanotechnology
is
increasing
every
day
in
different
fields
and,
especially,
the
application
nanomaterials
has
attracted
considerable
attention
food
safety.
Among
nanomaterials,
MXenes,
which
are
two-dimensional
(2D)
transition
metal-based
layered
materials
made
nitrides
and
carbides,
have
revolutionized
various
as
a
cutting-edge
scientific
discovery
nanotechnology.
These
been
widely
used
structure
biosensors
sensors
due
to
their
excellent
metallic
conductivity,
mechanical
stability,
optical
absorbance,
good
redox
capability,
higher
heterogeneous
electron
transfer
rate.
In
particular,
MXenes
nanozymes
highlighted
high
performance
great
extent
biosensor
domains.
growing
interest
these
attributed
specific
physicochemical
features.
key
enzymatic
features
include
activities
similar
oxidase,
peroxidase,
catalase,
superoxide
dismutase.
this
review,
initially,
several
common
synthesis
methods
presented,
emphasizing
significant
role
constructing
efficient
sensors.
Subsequently,
applications
MXene
safety
analysis
delved
into,
including
detection
bacteria,
mycotoxins,
antibiotic
residues,
pesticide
along
with
electrochemical
biosensors.
addition,
gap,
limitation,
future
perspective
novel
highlighted.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
Small,
Journal Year:
2024,
Volume and Issue:
20(44)
Published: July 5, 2024
Despite
the
advantages
of
high
tissue
penetration
depth,
selectivity,
and
non-invasiveness
photothermal
therapy
for
cancer
treatment,
developing
NIR-II
agents
with
desirable
performance
advanced
theranostics
ability
remains
a
key
challenge.
Herein,
universal
surface
modification
strategy
is
proposed
to
effectively
improve
vanadium
carbide
MXene
nanosheets
(L-V
