Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 59 - 76

Published: Jan. 8, 2025

Language: Английский

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Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Acute kidney injury (AKI) occurs when there is an imbalance in the immune microenvironment, leading to ongoing and excessive inflammation. Numerous immunomodulatory therapies have been suggested for treatment of AKI, current delivery systems are suboptimal lack efficiency. Given effective treatment, AKI can result multi‐organ dysfunction even death, imposing a significant healthcare burden on both family society. This underscores necessity innovative systems, such as nanomaterials, better control pathological inflammation, ultimately enhance outcomes. Despite modification numerous nanomaterials target microenvironment with promising therapeutic results, literature concerning their intersection scarce. In this article, pathophysiological processes outlined, focusing discuss advances comprehension recovery, describe multifunctionality suitability nanomaterial‐based treatments managing AKI. The main obstacles potential opportunities swiftly advancing research field also clarified.

Language: Английский

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Recent advances of photoresponsive nanomaterials for diagnosis and treatment of acute kidney injury

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 5, 2024

Non-invasive imaging in the near-infrared region (NIR) offers enhanced tissue penetration, reduced spontaneous fluorescence of biological tissues, and improved signal-to-noise ratio (SNR), rendering it more suitable for vivo deep imaging. In recent years, a plethora NIR photoresponsive materials have been employed disease diagnosis, particularly acute kidney injury (AKI). These encompass inorganic nonmetallic such as carbon (C), silicon (Si), phosphorus (P), upconversion nanoparticles (UCNPs); precious metal like gold silver; well small molecule organic semiconductor polymer with near infrared responsiveness. enable effective therapy triggered by light serve valuable tools monitoring AKI living systems. The review provides concise overview current state pathological characteristics AKI, followed an exploration application nanomaterials AKI. Finally, presents design challenges prospects associated

Language: Английский

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Harnessing the power of nanoagents in acute kidney injury: A versatile platform for imaging and treatment

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216570 - 216570

Published: Feb. 27, 2025

Language: Английский

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Macrophage membrane-mimicking nanoparticles for scavenging reactive oxygen species and modulating immune cells in acute kidney injury treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161135 - 161135

Published: Feb. 1, 2025

Language: Английский

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Defect-engineered nanoscale metal-organic frameworks as self-cascade antioxidation nanozymes for targeted therapy of cisplatin-induced acute kidney injury

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163893 - 163893

Published: May 1, 2025

Language: Английский

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Current advances in nanomedicine-based therapies for acute kidney injury

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110802 - 110802

Published: Dec. 1, 2024

Language: Английский

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