Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases

Small, Journal Year: 2025, Volume and Issue: 21(9)

Published: Jan. 22, 2025

Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.

Language: Английский

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Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis pyroptosis have been identified as contributors to neuronal damage during secondary phase following SCI. Therefore, this study focuses on development self‐enhancing drug pair‐driven selenium (Se) nanotherapeutics, loading with 2,3,5,6‐tetramethylpyrazine (TMP) Ginsenoside Rg1 (Rg1), enhance treatment The engineered LET/TMP/Rg1@Se NPs exhibits remarkable antioxidant properties, effectively reducing oxidative by minimizing reactive oxygen species (ROS) accumulation restoring mitochondrial function. In addition their effects, nanotherapeutics demonstrates significant anti‐pyroptotic effects BV2 microglial cells modulating NLRP3/caspase‐1 pathway, leading decreased release pro‐inflammatory cytokines IL‐1β IL‐18. Moreover, inhibition inflammatory cascade response diminishes neuroinflammation‐induced promotes axonal regeneration neurons vitro. mouse model SCI, improved function regeneration, attributed pyroptosis, highlighting scientific basis for synergistic effect Se an innovative strategy effective SCI therapy.

Language: Английский

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Orally Administered Zn_xCe_yO₂/Se Hydrogel with Effective Antioxidant Activity for Treating Inflammatory Bowel Disease by Inhibiting Ferroptosis

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Oxidative stress leads to intestinal barrier damage, which induces immune responses occur and further promotes oxidative exacerbating inflammatory bowel disease (IBD). In this work, the multifunctional Zn x Ce y O 2 /Se (ZCSO) nanozyme wrapped with acid‐resistant calcium alginate hydrogel designed for oral administration is prepared. The ZCSO can promote activation of Nrf2 pathway, then significantly improve efficiency scavenging reactive oxygen species (ROS) up‐regulate protein expression glutathione peroxidase 4 (GPx4), closely related inhibition ferroptosis. addition, inhibiting growth some pathogenic bacteria proliferating due shows a positive regulation flora reduces secretion pro‐inflammatory factors levels macrophages, achieving significant preventive delayed therapeutic effect colitis mice. Consequently, distinctive properties render it promising candidate treatment IBD by effectively ROS, thereby interrupting detrimental cycle between response, ultimately promoting proliferation epithelial cells reestablish integrity mucosal barrier.

Language: Английский

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Recent Advances in Nanotechnology for Repairing Spinal Cord Injuries

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123422 - 123422

Published: May 1, 2025

Language: Английский

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Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an important challenge improve immunotherapy. Non‐apoptotic death mode ferroptosis has been regarded as a new strategy enhance immunotherapy against drug‐resistant cancers. The lethal accumulation lipid peroxides (LPO) determines progress ferroptosis. high susceptibleness provides opportunity for combating triple‐negative breast cancer. Reactive nitrogen species (RNS) produced by nitric oxide (NO) reactive oxygen (ROS) more than ROS cells. Herein, RNS‐mediated inducing pathway proposed improving LPO accumulation, constructed multifunctional liposome (Lipo‐MT‐SNAP) comprised peroxynitrite (ONOO − ) generator, targeted group, inhibiting glutathione peroxidase 4 (GPX4), basic units (dipalmitoyl phosphatidylcholine cholesterol). significant enhancement resulted from intense oxidative damage ONOO impaired synthesis GPX4 depleting glutathione, which further amplified triggered immunogenic cell death. In vivo, photoimmunotherapy can promote polarization M2 M1 macrophages dendritic maturation, infiltrate T cells, regulate secretion inflammatory factors, reprogram microenvironment. powerful induces strong immunogenicity effectively inhibit proliferation.

Language: Английский

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ROS responsive quercetin nanoparticles with neuron-targeted peptide inhibits ferroptosis to repair spinal cord injury

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158386 - 158386

Published: Dec. 9, 2024

Language: Английский

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