Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms DOI Creative Commons
Kristin Moskal, Nimisha Khurana,

Luisa Siegert

et al.

International Journal of Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

The biology of cancer is characterized by an intricate interplay cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggested to be enriched in tumors and impacts these on phenotypes subject intensive investigation. For efforts, model systems that accurately reflect human-microbe interactions are rapidly gaining importance. Here we present a guide for selecting suitable vitro co-culture platform used different cancer-microbiome interactions. Our discussion spans variety models, including 2D cultures, spheroids, organoids, organ-on-a-chip platforms, where delineate their respective advantages, limitations, applicability microbiome research. Particular focus placed methodologies facilitate exposure microbes, such as organoid microinjections microfluidic devices. We highlight studies offering critical insights into possible cancer-microbe underscore importance models those discoveries. anticipate integration more complex communities inclusion immune simulate microenvironment. advent ever sophisticated will aid unraveling mechanisms contribute exploiting potential novel diagnostic therapeutic strategies.

Language: Английский

Biological and environmental degradation of two-dimensional materials DOI
Sandra Vranic, Rajendra Kurapati, Kostas Kostarelos

et al.

Nature Reviews Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

3
Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects DOI Creative Commons
J. B. Thomas, Vinay Kumar, Neha Sharma

et al.

Medicine in Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204

Published: Feb. 1, 2025

Language: Английский

Citations

2
Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective DOI Creative Commons
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Two‐dimensional (2D) graphene‐based nanomaterials (GNMs) have shown potential in biomedical applications, including diagnostics, therapeutics, and drug delivery, due to their unique combination of properties such as mechanical strength, excellent electrical thermal conductivity well high adsorption capacity which, combined with the ease surface functionalization, enable biocompatibility bioactivity. Theoretical molecular modeling can advance our understanding 2D by providing insights into structure, dynamics, interactions these biological systems, at level detail that experiments alone cannot currently access. This perspective highlights recent computational advances challenges examining physiologically relevant biomolecular aqueous solutions, peptides, proteins, nucleic acids, lipid membranes, pharmaceutical molecules. Examples theoretical contributions design biomaterials devices are also provided.

Language: Английский

Citations

0
Twenty years of in vitro nanotoxicology: how AI could make the difference DOI Creative Commons
Luisa Campagnolo, Valentina Lacconi, Joanna Filippi

et al.

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 18, 2024

More than two decades ago, the advent of Nanotechnology has marked onset a new and critical field in science technology, highlighting importance multidisciplinary approaches to assess model potential human hazard newly developed advanced materials nanoscale, nanomaterials (NMs). is, by definition, field, that integrates knowledge techniques from physics, chemistry, biology, science, engineering manipulate matter at defined as anything comprised between 1 100 nm. The emergence nanotechnology undoubtedly led significant innovations many fields, medical diagnostics targeted drug delivery systems energy solutions. However, unique properties nanomaterials, such increased surface volume ratio, which provides reactivity hence ability penetrate biological barriers, have been also considered risk factors for unforeseen toxicological effects, stimulating scientific community investigate extent this applications could pose health environment.

Language: Английский

Citations

2
Nanomaterials in Organoids: From Interactions to Personalized Medicine DOI
Ying Shi,

Xin Han,

Siyi Zou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Organoids are three-dimensional models of microscopic organisms created through the self-organization various types stem cells. They widely unitized in personalized medicine due to their capacity replicate structure and functionality native organs. Meanwhile, nanotechnology has been integrated into diagnostic therapeutic tools manage an array medical conditions, given its unique characteristics nanoscale. Nanomaterials have demonstrated potential developing innovative effective organoids. With a focus on studying interaction nanomaterials organoid technology medicine, this Review examines role regulating fate cells construct different It also explores create 3D microenvironments for Finally, perspectives challenges applying organoids development toward translation discussed.

Language: Английский

Citations

2
Unravelling the toxicity of carbon nanomaterials – From cellular interactions to mechanistic understanding DOI

Bveledzani P. Makhado,

Adewale O. Oladipo, Nozipho N. Gumbi

et al.

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: 100, P. 105898 - 105898

Published: July 17, 2024

Language: Английский

Citations

1
Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms DOI Creative Commons
Kristin Moskal, Nimisha Khurana,

Luisa Siegert

et al.

International Journal of Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

The biology of cancer is characterized by an intricate interplay cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggested to be enriched in tumors and impacts these on phenotypes subject intensive investigation. For efforts, model systems that accurately reflect human-microbe interactions are rapidly gaining importance. Here we present a guide for selecting suitable vitro co-culture platform used different cancer-microbiome interactions. Our discussion spans variety models, including 2D cultures, spheroids, organoids, organ-on-a-chip platforms, where delineate their respective advantages, limitations, applicability microbiome research. Particular focus placed methodologies facilitate exposure microbes, such as organoid microinjections microfluidic devices. We highlight studies offering critical insights into possible cancer-microbe underscore importance models those discoveries. anticipate integration more complex communities inclusion immune simulate microenvironment. advent ever sophisticated will aid unraveling mechanisms contribute exploiting potential novel diagnostic therapeutic strategies.

Language: Английский

Citations

1