Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 3, 2024

Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form inflammatory programmed cell death, presents dependable strategy combating cancer by engaging multiple death pathways (apoptosis, pyroptosis, necroptosis). In this study, ultrasmall Bi 2 Sn O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties designed engineered as PANoptosis inducer through destroying mitochondrial function tumor cells enhancing intracellular accumulation toxic reactive oxygen species, finally triggering activation process. The role has been verified expression related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, 1, p‐MLKL, RIPK3. inclusion external ultrasonic irradiation significantly augments enzyodynamic efficiency. vitro in vivo antineoplastic efficacy, along inhibition lung metastasis, validate benefits ‐mediated pathway. This study not only elucidates intricate mechanisms underlying inducer, but also offers novel perspective treatment carcinoma.

Language: Английский

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Recent progress in noble metal-based single-atom nanozymes for biomedical applications

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111731 - 111731

Published: Sept. 1, 2024

Language: Английский

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Mitoxantrone Combined with Engineered TRAIL‐Nanovesicles for Enhanced Cancer Immunotherapy Via Converting Apoptosis into Pyroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 24, 2024

Pyroptosis, a highly inflammatory form of programmed cell death, has emerged as promising target for cancer immunotherapy. However, in the context pyroptosis execution, while both caspase-3 and GSDME are essential, it is noteworthy that frequently under-expressed cold tumors. To overcome this limitation, engineered cellular nanovesicles (NVs) presenting TRAIL on their membranes (NV

Language: Английский

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Bioorthogonally activated probes for precise fluorescence imaging

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This article provides a comprehensive overview of recent advances in the development bioorthogonally activated probes for labelling and precise situ fluorescence imaging both vitro vivo .

Language: Английский

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Bioorthogonal reaction-mediated photosensitizer–peptide conjugate anchoring on cell membranes for enhanced photodynamic therapy

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study introduces a cell membrane-targeting peptide–photosensitizer conjugate, which leverages in vivo bioorthogonal reactions for long-term membrane and tumor retention, leading to effective single-session elimination.

Language: Английский

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Thienylquinoline-Based Ionic Iridium(III) Complexes as Highly Efficient Sonosensitizers for Sonodynamic Therapy

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123547 - 123547

Published: Jan. 1, 2025

Language: Английский

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Nanomaterials as Modulators of Non-apoptotic Regulated Cell Death Modes: Novel Options in Cancer Treatment

Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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MnO2 and sonosensitizer-based nano-platforms for cancer sonodynamic therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157232 - 157232

Published: Oct. 30, 2024

Language: Английский

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PANoptosis: A new era for anti-cancer strategies

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123241 - 123241

Published: Nov. 1, 2024

Language: Английский

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Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become critical strategy for treatment. PANoptosis, newly discovered form of regulated death, integrates key molecular components pyroptosis, apoptosis, and necroptosis, activating these three pathways simultaneously achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits growth resistance activates strong anti‐tumor immune response, making tumor‐specific induction potential therapeutic strategy. Currently, treatment research related is focused mainly on the development small molecules cytokines. However, approaches still face limitations terms metabolic stability tumor specificity. The unique physicochemical properties biological activities nanomaterials hold promise optimizing strategies. This review summarizes concept mechanisms highlights latest applications nanoagents PANoptosis‐based anti‐cancer therapy, discusses challenges future directions clinical translation. It hoped that this will inspire further exploration treatments, providing new perspectives researchers field.

Language: Английский

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