Engineering of calcium overload for state-of-the-art tumor therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157747 - 157747

Published: Nov. 17, 2024

Language: Английский

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Nebulized Immunotherapy of Orthotopic Lung Cancer by Mild Magnetothermal–based Innate Immunity Activations

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 30, 2024

Abstract Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over‐low efficacy and insufficient invasion immune cells tumor tissue, safety problems caused by cytokine storm, seriously impeded further clinical application for solid Notably, microenvironment lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy treat orthotopic lung using nanomaterial (Zn−CoFe 2 O 4 @Zn−MnFe −PEG, named ZCMP), which can release iron ions via an acid/thermal‐catalytic reaction maximize use lung‘s environment through cascade activations AMs natural killer (NK) cells. Nebulized administration enhance drug bioavailability localized accumulation at lesion site. Upon mild magnetic hyperthermia, released catalyze endogenous H decomposition produce reactive oxygen species (ROS), triggers M1 polarization AMs, resultant inflammatory IFN‐β, IL‐1β IL‐15 releases activate c‐Jun, STAT5 GZMB related signaling pathways, promoting NK proliferation activation. This innovative optimally utilizes shows excellent immunotherapeutic outcomes against cancer.

Language: Английский

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Nebulized Immunotherapy of Orthotopic Lung Cancer by Mild Magnetothermal–based Innate Immunity Activations

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Sept. 30, 2024

Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over-low efficacy and insufficient invasion immune cells tumor tissue, safety problems caused by cytokine storm, seriously impeded further clinical application for solid Notably, microenvironment lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy treat orthotopic lung using nanomaterial (Zn-CoFe

Language: Английский

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Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(1), P. 117 - 136

Published: Nov. 6, 2024

This article reviews the application of biomaterials in combination with immunotherapy to enhance localized treatment tumors, along current challenges and future development directions this field.

Language: Английский

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