Tailoring cell-inspired biomaterials to fuel cancer therapy DOI Creative Commons
Qihui Wang, Shi Cheng,

Cunhao Han

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101381 - 101381

Published: Dec. 6, 2024

Cancer stands as a predominant cause of mortality across the globe. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, are effective yet face challenges like normal tissue damage, complications, drug resistance. Biomaterials, with their advantages high efficacy, targeting, spatiotemporal controllability, have been widely used in treatment. However, biocompatibility limitations traditional synthetic materials restricted clinical translation application. Natural cell-inspired biomaterials inherently possess targeting abilities cells, biocompatibility, immune evasion capabilities. Therefore, can be alone or combination other drugs treatment strategies for therapy. In this review, we first introduce timeline key milestones Then, describe abnormalities biophysics, cellular biology, molecular biology aspects. Afterwards, summarize design antitumor biomaterials. Subsequently, elaborate on application inspired by various cell types. Finally, explore current prospects materials. This review aims to provide new opportunities references development

Language: Английский

Mitochondria-targeted astaxanthin prevents oxidative stress in intestinal crypt epithelial cells by regulating redox balance and mitophagy DOI
Xiaoting Yu, Xunyu Song, Yannan Chen

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106537 - 106537

Published: April 1, 2025

Language: Английский

Citations

0
Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus DOI Creative Commons

Alberto J. Nuñez-Selles,

Rodolfo A. Nuñez-Musa,

Rafael A. Guillen-Marmolejos

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 26, 2025

Oxidative stress (OS) is increasingly recognized as a key factor linking hypertension (HTN) and diabetes mellitus (DM). This review summarizes recent evidence regarding the dual role of OS both an instigator amplifier cardiometabolic dysfunction. In HTN, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) mitochondrial dysfunction contribute to endothelial impairment vascular remodeling. DM, hyperglycemia-induced ROS production worsens beta-cell failure insulin resistance through pathways such AGE-RAGE signaling, protein kinase C (PKC) activation, polyol pathway. Clinically validated biomarkers OS, F2-isoprostanes (which indicate lipid peroxidation), 8-OHdG indicates DNA damage), activities redox enzymes like superoxide dismutase (SOD) glutathione peroxidase (GPx), show strong correlations with disease progression end-organ complications. Despite promising preclinical results, application antioxidant therapies in clinical settings has faced challenges due inconsistent outcomes, highlighting need for targeted approaches. Emerging strategies include: 1. Mitochondria-targeted antioxidants enhance function resistant HTN; 2. Nrf2 activators restore balance early diabetes; 3. Specific inhibitors NOX isoforms. We emphasize three transformative areas research: (i) interaction between microbiome ROS, where modifying gut microbiota can reduce systemic OS; (ii) use nanotechnology deliver directly pancreatic islets or atherosclerotic plaques; (iii) phenotype-specific diagnosis therapy guided genetic profiling (for example, KEAP1/NRF2 polymorphisms). Integrating these advances lifestyle modifications, following Mediterranean diet exercising regularly, may provide additional benefits. outlines mechanistic framework targeting comorbidity HTN DM while identifying critical knowledge gaps, particularly timing signaling development personalized medicine, which serve reference researchers clinicians working this area.

Language: Английский

Citations

0
Mitochondrial targeted prodrug nanoparticles for chemo-photodynamic combinational tumour therapy DOI Creative Commons
Rong Xu,

Encan Zhu,

Xiaoyun Lan

et al.

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(3), P. 373 - 385

Published: Aug. 8, 2024

Prodrug nanoparticles have been explored as an effective means for drug delivery because of controlled release in a stimulus-responsive manner. Organellar-targeted could enhance the efficacy cancer therapy. Herein, pH and light dual responsive mitochondrial targeted prodrug were designed to deliver both chemotherapeutic drugs photosensitisers enhanced antitumour efficacy. The (TPP-PEI-PheoA/ALG=DOX NPs, TPPAD NPs) are composed light-responsive (triphenylphosphonium pheophorbide A modified polyethyleneimine, TPP-PEI-PheoA) pH-responsive (doxorubicin conjugated alginate with Schiff's base bond, ALG=DOX). NPs prepared through electrostatic interaction. simultaneously DOX PheoA tumour site by passive targeting effect, mode target organelles. Moreover, NP-based PDT induce immunogenic cell death cells, thereby activating immune system. greatly combinational Taken together, this nanoparticle platform has appeared be simple smart nanomedicine treatment.

Language: Английский

Citations

2
Tailoring cell-inspired biomaterials to fuel cancer therapy DOI Creative Commons
Qihui Wang, Shi Cheng,

Cunhao Han

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101381 - 101381

Published: Dec. 6, 2024

Cancer stands as a predominant cause of mortality across the globe. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, are effective yet face challenges like normal tissue damage, complications, drug resistance. Biomaterials, with their advantages high efficacy, targeting, spatiotemporal controllability, have been widely used in treatment. However, biocompatibility limitations traditional synthetic materials restricted clinical translation application. Natural cell-inspired biomaterials inherently possess targeting abilities cells, biocompatibility, immune evasion capabilities. Therefore, can be alone or combination other drugs treatment strategies for therapy. In this review, we first introduce timeline key milestones Then, describe abnormalities biophysics, cellular biology, molecular biology aspects. Afterwards, summarize design antitumor biomaterials. Subsequently, elaborate on application inspired by various cell types. Finally, explore current prospects materials. This review aims to provide new opportunities references development

Language: Английский

Citations

1