Cited by A bacteria-responsive nanoplatform with biofilm dispersion and ROS scavenging for the healing of infected diabetic wounds

Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds DOI

Wenxin Qi, Yihao Liu,

Naijun Dong

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Bacterial infections in wounds and bacteremia present significant global health challenges, driving the urgent need for innovative alternatives to traditional antibiotics. Here, development of PEI-EDTA-2Na carbon quantum dots (PECDs) synthesized via a hydrothermal method is reported. Synthesis conditions affect PECDs' antibacterial efficacy; those at 180 °C have optimal -NH2 functionalization better adhesion activity. PECDs are pH - responsive, eradicating bacteria weakly acidic by disrupting DNA proteins. Following resolution infection, adapt neutral alkaline environments, where they scavenge reactive oxygen species (ROS), reduce inflammation, promote macrophage polarization, accelerate wound healing. Furthermore, significantly improve survival models. Their intrinsic fluorescence enables real-time monitoring wounds, offering non-invasive diagnostic tool. Genomic transcriptomic analyses reveal that disrupt bacterial metabolism resistance pathways, while simultaneously supporting anti-inflammatory responses during tissue repair. This dual functionality-combining therapeutic efficacy healing with antimicrobial properties bacteremia-positions as versatile platform smart management an emerging candidate advanced biomedical applications.

Language: Английский

Citations

NIR responsive electrospun composite membranes for on-demand delivery of Ag ions to enhance treatment of bacteria-infected wounds DOI

Yuhan Zhang,

Chenhuan Wu,

Yonghe Zhao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 514, P. 163428 - 163428

Published: May 5, 2025

Language: Английский

Citations

Borate and Disulfide Dual‐Dynamic Hydrogel for ROS Dual‐Scavenging DOI

Xing Wang,

Haohao Cui,

Qingyun Ning

et al.

Journal of Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

ABSTRACT The excessive accumulation of reactive oxygen species (ROS) on wound surfaces poses considerable challenges to the healing process, as it exacerbates inflammation and heightens risk skin infections. Consequently, development multifunctional dressings that possess both ROS‐scavenging antimicrobial properties is clinical significance for enhancing healing. To address these challenges, we synthesized a dual‐scavenging hydrogel utilizing dual‐dynamic crosslinking techniques. This composed poly‐lysine‐grafted D‐glucono‐1,5‐lactone, dithiodipropionic acid/lipoic acid, dopamine (PLGDTD), in conjunction with borax. attributes can be attributed incorporation borate esters, dopamine, disulfide bonds. Experimental results demonstrate this exhibits robust antioxidant capacity pronounced inhibitory effect against Staphylococcus aureus Escherichia coli . cellular studies indicate capable effectively scavenging ROS mitigating oxidative stress, attributable its mechanism involving demonstrates significant potential candidate associated ROS.

Language: Английский

Citations

A bacteria-responsive nanoplatform with biofilm dispersion and ROS scavenging for the healing of infected diabetic wounds DOI

Zheng Yin, Mingyue Wang, Xinge Zhang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations