Emerging nanomedicines for macrophage-mediated cancer therapy DOI
Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123028 - 123028

Published: Dec. 15, 2024

Language: Английский

Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics DOI

Xiaochun Bian,

Liping Zhou,

Zhiwei Luo

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.

Language: Английский

Citations

2
Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases DOI

Seyedeh Ghazal Moosavi,

Niloufar Rahiman, Mahmoud Reza Jaafari

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113641 - 113641

Published: March 1, 2025

Language: Английский

Citations

0
Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems DOI Creative Commons
Yuxuan Liu, Yongkang Ou, Linlin Hou

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 22 - 22

Published: Dec. 31, 2024

Nucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, drug development. Among various types nucleic RNA offers greater versatility compared to DNA due its single-stranded structure, ability directly encode proteins, high modifiability for targeted therapeutic regulatory applications. Despite promising potential biomedicine, RNA-based medicine still faces several challenges. Notably, one the most significant technical hurdles is achieving efficient delivery while minimizing immune responses. Various strategies been developed delivery, viral vectors, virus-like particles (VLPs), lipid nanoparticles (LNPs), extracellular vesicles (EVs). In this review, we explore these methods, highlight their advantages limitations, discuss recent advancements, providing insights future therapeutics.

Language: Английский

Citations

1
Emerging nanomedicines for macrophage-mediated cancer therapy DOI
Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123028 - 123028

Published: Dec. 15, 2024

Language: Английский

Citations

0