Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy DOI Creative Commons
Ying‐Chi Chen, Li-Chan Chang,

Yanling Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 5, 2025

Cancer remains a global health challenge necessitating innovative therapies. We introduce strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched c-type cytochromes. These, coupled Au NPs, facilitate autonomous transfer from cells, disrupting processes and inducing death. Effective across various types, larger NPs show enhanced efficacy, especially under hypoxic conditions. Oxidative stress Au@MIL (MIL: membrane-integrated liposome) treatments, including mitochondrial endoplasmic reticulum lipid oxidation potential changes, triggers apoptosis, bypassing iron-mediated pathways. Surface plasmon band X-ray absorption near-edge structure (XANES) analyses confirm transfer. A SiO2 insulator coating on blocks this transfer, suppressing damage. This approach highlights the of modulated pathways in targeted therapy, offering refined effective treatments.

Language: Английский

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy DOI Creative Commons
Ying‐Chi Chen, Li-Chan Chang,

Yanling Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 5, 2025

Cancer remains a global health challenge necessitating innovative therapies. We introduce strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched c-type cytochromes. These, coupled Au NPs, facilitate autonomous transfer from cells, disrupting processes and inducing death. Effective across various types, larger NPs show enhanced efficacy, especially under hypoxic conditions. Oxidative stress Au@MIL (MIL: membrane-integrated liposome) treatments, including mitochondrial endoplasmic reticulum lipid oxidation potential changes, triggers apoptosis, bypassing iron-mediated pathways. Surface plasmon band X-ray absorption near-edge structure (XANES) analyses confirm transfer. A SiO2 insulator coating on blocks this transfer, suppressing damage. This approach highlights the of modulated pathways in targeted therapy, offering refined effective treatments.

Language: Английский

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