Iron Homeostasis-Regulated Adaptive Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles DOI
Ning Wang, Dandan Zhou, Keyang Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Iron oxide nanoparticles have become increasingly significant in the biomedical field due to their exceptional magnetic properties and biocompatibility. However, understanding vivo metabolism transformation is crucial potential biological effects they may induce. This study investigates metabolic pathways of PEGylated ultrasmall iron (PUSIONPs) vivo, particularly under varying statuses dosages. Employing a comprehensive analytical approach─including resonance imaging, elemental analysis, histological assessments, hematological Western blot analysis─the biodistribution PUSIONPs were mapped. The findings reveal differences fate between iron-sufficient iron-deficient conditions, underscoring pivotal role homeostasis regulating biodegradation. In states, degradation markedly accelerated, with released rapidly incorporated into hemoglobin. Additionally, liver spleen exhibited different rates distinct physiological roles: spleen, primarily responsible for recycling, facilitated faster degradation, while liver, serving as an storage organ, showed slower degradation. Under deficiency, most products directed toward hemoglobin synthesis, whereas normal gradually metabolized products, retained higher levels. Moreover, demonstrated dose dependency, doses slowing reducing utilization rate by body. Comprehensive safety evaluations confirmed that exhibit excellent biocompatibility across all doses, no concerns. Compared clinically used intravenous supplement sucrose, also superior bioavailability more effective supplementation. These provide critical insights interaction metabolism, offering foundation future research broader application contexts.

Language: Английский

Iron Homeostasis-Regulated Adaptive Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles DOI
Ning Wang, Dandan Zhou, Keyang Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Iron oxide nanoparticles have become increasingly significant in the biomedical field due to their exceptional magnetic properties and biocompatibility. However, understanding vivo metabolism transformation is crucial potential biological effects they may induce. This study investigates metabolic pathways of PEGylated ultrasmall iron (PUSIONPs) vivo, particularly under varying statuses dosages. Employing a comprehensive analytical approach─including resonance imaging, elemental analysis, histological assessments, hematological Western blot analysis─the biodistribution PUSIONPs were mapped. The findings reveal differences fate between iron-sufficient iron-deficient conditions, underscoring pivotal role homeostasis regulating biodegradation. In states, degradation markedly accelerated, with released rapidly incorporated into hemoglobin. Additionally, liver spleen exhibited different rates distinct physiological roles: spleen, primarily responsible for recycling, facilitated faster degradation, while liver, serving as an storage organ, showed slower degradation. Under deficiency, most products directed toward hemoglobin synthesis, whereas normal gradually metabolized products, retained higher levels. Moreover, demonstrated dose dependency, doses slowing reducing utilization rate by body. Comprehensive safety evaluations confirmed that exhibit excellent biocompatibility across all doses, no concerns. Compared clinically used intravenous supplement sucrose, also superior bioavailability more effective supplementation. These provide critical insights interaction metabolism, offering foundation future research broader application contexts.

Language: Английский

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