Enhancing sleep quality in synucleinopathies through physical exercise

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 31, 2025

During sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential memory formation and updating. Sleep also facilitates removal neurotoxic waste products, accumulation plays a key role in neurodegeneration. Various neural components environmental factors regulate influence physiological transition between wakefulness sleep. Disruptions this complex system form basis sleep disorders, as commonly observed synucleinopathies. Synucleinopathies are neurodegenerative disorders characterized by abnormal build-up α-synuclein protein aggregates brain. This different regions leads to spectrum clinical manifestations, hypokinesia, cognitive impairment, psychiatric symptoms, neurovegetative disturbances. highly prevalent individuals with synucleinopathies, they not only affect overall well-being patients but directly contribute disease severity progression. Therefore, it develop effective therapeutic strategies improve quality these patients. Adequate vital health, synucleinopathies disrupting patterns must be taken into account. In context, explore physical exercise potential non-pharmacological intervention manage The current evidence on efficacy programs enhance patient population discussed.

Language: Английский

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Brain Metabolite Profiles are Associated with Selective Neuronal Vulnerability and Underlying Mechanisms in Amyotrophic Lateral Sclerosis

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Amyotrophic lateral sclerosis (ALS) is a lethal neurological syndrome accompanied by selective degeneration of somatic motor neurons and neurochemistry alterations. Nevertheless, eye movement's nuclei are relatively spared from ALS damage. This survey was to probe metabolite changes in the primary cortex (PMC) interstitial nucleus Cajal (INC) patients using proton magnetic resonance spectroscopy (1H-MRS). In this case-control study, 20 with healthy controls underwent 1.5 T MRI multivoxel 1H-MRS. 1H-MRS spectra determine profiles including tNAA, mIns, tCr, tCho, also tNAA/tCr, tNAA/tCho, mIns/tNAA ratios PMC INC were quantified via point resolved pulse (PRESS) sequence two groups. Further, associations between markers forced vital capacity (FVC), functional rating scale (ALSFRS-R), disease progression rate (ΔFS) investigated. PMC, tNAA tNAA/tCr significantly lower than controls, but mIns greater these (p < 0.05). INC, tCho concentrations, ratio increased 0.05) patients, while did not show significant discriminations groups > The tNAA/Cr associated ALSFRS-R = 0.001, r 0.71), FVC 0.03, 0.58), ΔFS 0.01, -0.33). 0.02, 0.41). concentrations 0.04, -0.54) -0.38) negatively positively correlated 0.33) 0.61), respectively. study suggests that patients' brains linked neuronal vulnerability underlying pathophysiology disease.

Language: Английский

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Neuroadaptation in neurodegenerative diseases: compensatory mechanisms and therapeutic approaches

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 139, P. 111375 - 111375

Published: April 23, 2025

Language: Английский

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Gamma Amino Butyric Acid (GABA) and Ferulic Acid Esterase (FAE) Producing Psychobiotic Bacteria Isolated from Cereal-Based Fermented Food

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(2)

Published: Jan. 10, 2024

Language: Английский

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Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 10, 2025

Neurologic impairment is common in patients with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. While severe COVID have a higher prevalence of neurologic symptoms, as many one five mild may also be affected, exhibiting impaired memory well other cognitive dysfunctions. To characterize the effect on brain, current study recruited group adults post-COVID complaints but mild, non-hospitalized cases. They were then evaluated through formal neuropsychological testing and underwent functional MRI brain. The participants our performed nearly expected for cognitively intact individuals. Additionally, we characterized connectivity default mode network (DMN), which known functions including attention involved normal aging degenerative diseases. Along retention DMN, results found DMN to associated neurocognitive performance region-of-interest whole-brain analyses. between key nodes was positively correlated scores (r = 0.51, p 0.02), performers connectivity. Our findings provide neuroimaging evidence brain networks among individuals experiencing deficits beyond recovery COVID. These imaging outcomes indicate trends furthering understanding guidance recovering from

Language: Английский

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Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102461 - 102461

Published: Sept. 1, 2024

Language: Английский

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Exploring neurofeedback as a therapeutic intervention for subjective cognitive decline

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(12), P. 7164 - 7182

Published: Nov. 26, 2024

Abstract Impact statement This study addresses the pressing issue of subjective cognitive decline in aging populations by investigating neurofeedback (NFB) as a potential early therapeutic intervention. By evaluating efficacy individualised NFB training compared to standard protocols, tailored each participant's EEG profile, it provides novel insights into personalised treatment approaches. The incorporation innovative elements and rigorous analytical techniques contributes advancing our understanding NFB's modulatory effects on frequencies function individuals. In context an population, concerns surrounding memory become increasingly prevalent, particularly individuals transition middle age beyond. investigated intervention address (SCD) populations. NFB, biofeedback technique utilising brain‐computer interface, has demonstrated promise various neurological psychological conditions. Here, we evaluated training, protocol aimed at increasing peak alpha frequency power, enhancing among experiencing SCD. Our incorporated elements, including implementation criterion for learning success ensure consistent achievement levels conclusion sessions. Additionally, introduced non‐learner group account who do not demonstrate expected proficiency regulation. Analysis electroencephalographic (EEG) signals during sessions, well before after frequencies. Contrary expectations, analysis revealed that ability with SCD modulate signal power duration specific was exclusive intended target. Furthermore, examination recorded using high‐density showed no discernible alteration between pre‐ post‐NFB Similarly, significant were observed questionnaire scores when comparing assessments.

Language: Английский

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Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis

Communications Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: June 22, 2023

Multiple Sclerosis lesions in the brain and spinal cord can lead to different symptoms, including cognitive mood changes. In this study we explore temporal relationship between early microstructural changes subcortical volumes emotional function a longitudinal cohort of patients with relapsing-remitting Sclerosis.In vivo imaging forty-six was performed annually over 3 years magnetic resonance imaging. Microstructural were estimated structures using free water fraction, diffusion-based MRI metric. parallel, assessed Hospital Anxiety Depression Scale amongst other tests. Predictive structural equation modeling set up further assessment scores. general linear model analysis, split into higher lower depression scores.Nearly all diffusion microstructure estimates at baseline visit correlate score 2 follow-up. The predictive nature subscores after are confirmed analysis thalamus showing greatest effect size. shows patterns differences amygdala/hippocampus area participants high low score.Our data suggests levels free-water an stage symptoms later disease.Signals disrupted people Sclerosis. For those (RRMS), get periodically better worse time. We looked whether RRMS associated their People who had more certain areas start likely have later. This work that may be linked increased time RRMS. believe could opportunity provide care suffering from lessen impact severe before they arise.

Language: Английский

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Editorial: The Current Categorical Concept of Schizophrenia is Inadequate: Should we Look at the Current State of Affairs for Compensatory Processes?

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(3)

Published: July 18, 2024

Language: Английский

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Phosphodiesterase Inhibitor ‘Rolipram’ Alleviates Sleep-Deprivation-Mediated Appetitive-Delay-Conditioned Memory in the Rat

Sleep and Vigilance, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Language: Английский

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