An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease DOI Creative Commons
Geraldine Kong, Susan Ellul, Vinod K. Narayana

et al.

Neurobiology of Disease, Journal Year: 2020, Volume and Issue: 148, P. 105199 - 105199

Published: Nov. 26, 2020

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance gastrointestinal microbiome in mediating gut-brain-axis bidirectional communication via circulating Using shotgun sequencing, we investigated gut composition R6/1 transgenic mouse model HD from 4 to 12 weeks age (early adolescent through adult stages). Targeted metabolomics was also performed on blood plasma these mice (n = 9 per group) at investigate potential effects dysbiosis metabolome profile.Modelled time profiles each species, KEGG Orthologs bacterial genes, revealed heightened volatility mice, indicating early mutation gut. In addition age, function perturbed. particular, butanoate metabolism pathway elevated, suggesting increased production protective SCFA, butyrate, No significant alterations were found butyrate propionate levels age. The statistical integration metagenomics unraveled several Bacteroides species that negatively correlated ATP pipecolic acid plasma.The present study instability during pre-motor symptomatic stage which may dire consequences host's health. Perturbation prior cognitive motor dysfunction suggest role modulating pathogenesis HD, potentially specific altered metabolites mediate gut-brain signaling.

Language: Английский

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions DOI Open Access

Suganya Kanmani,

Byung‐Soo Koo

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7551 - 7551

Published: Oct. 13, 2020

The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has largest and vulnerable surface with desirable features to observe foods, nutrients, environmental factors, well differentiate commensals, invading pathogens, others. It is well-known a strong connection central nervous system (CNS) in context health disease. A healthy diverse microbes vital for normal brain functions emotional behaviors. In addition, CNS controls most aspects GI physiology. molecular interaction between gut/microbiome complex bidirectional, ensuring maintenance homeostasis proper digestion. Besides this, several mechanisms have been proposed, including endocrine, neuronal, toll-like receptor, metabolites-dependent pathways. Changes bidirectional relationship GIT are linked pathogenesis neurological disorders; therefore, microbiota/gut-and-brain axis emerging widely accepted concept. this review, we summarize recent findings supporting role microbiota immune on development disorders. highlight advances improving diseases by probiotics/prebiotics/synbiotics fecal transplantation via concept gut–brain axis.

Language: Английский

Citations

241
The Microbiota–Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Aleksandra Góralczyk-Bińkowska, Dagmara Szmajda‐Krygier, Elżbieta Kozłowska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11245 - 11245

Published: Sept. 24, 2022

Modulating the gut microbiome and its influence on human health is subject of intense research. The microbiota could be associated not only with gastroenterological diseases but also psychiatric disorders. importance factors such as stress, mode delivery, role probiotics, circadian clock system, diet, occupational environmental exposure in relationship between brain function through bidirectional communication, described "the microbiome-gut-brain axis", especially underlined. In this review, we discuss link intestinal host response involving different pathways nervous system (e.g., neurotransmitters, endocrine immunological mechanisms, or bacterial metabolites). We review alterations their results development disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar (BD), autism spectrum (ASD), attention-deficit hyperactivity (ADHD).

Language: Английский

Citations

233
The Microbiome as a Modifier of Neurodegenerative Disease Risk DOI Creative Commons
Ping Fang, Sabeen A. Kazmi, Kelly G. Jameson

et al.

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 28(2), P. 201 - 222

Published: Aug. 1, 2020

Language: Английский

Citations

186
Circular bioeconomy and integrated biorefinery in the production of xylooligosaccharides from lignocellulosic biomass: A review DOI

César D. Pinales‐Márquez,

Rosa M. Rodríguez‐Jasso, Rafael G. Araújo

et al.

Industrial Crops and Products, Journal Year: 2021, Volume and Issue: 162, P. 113274 - 113274

Published: Jan. 29, 2021

Language: Английский

Citations

142
Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases DOI Creative Commons
Shuai Jiang, Hui Liu, Chunbao Li

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(8), P. 1854 - 1854

Published: Aug. 11, 2021

Oxidative stress is a status of imbalance between oxidants and antioxidants, resulting in molecular damage interruption redox signaling an organism. Indeed, oxidative has been associated with many metabolic disorders due to unhealthy dietary patterns may be alleviated by properly increasing the intake antioxidants. Thus, it quite important adopt healthy mode regulate maintain cell tissue homeostasis, preventing inflammation chronic diseases. This review focuses on links nutrients health, summarizing role 'unhealthy' pathway activities individuals how further regulated balanced diets.

Language: Английский

Citations

132
Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders DOI Creative Commons

Md. Tanvir Kabir,

Md. Habibur Rahman,

Muddaser Shah

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 146, P. 112610 - 112610

Published: Jan. 4, 2022

Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, Huntington's and multiple sclerosis have various disease-specific causal factors pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation reactive oxygen species during progression NDs. Furthermore, condition an increased level protein aggregates can further lead chronic inflammation because microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs present nature, they widely available plants, microorganisms, animals. accountable for red, yellow, orange several animals these colors usually indicate types CTs. exert bioactive properties its structure, anti-inflammatory antioxidant properties. Due protective CTs, levels human body been markedly linked with prevention treatment diseases In this review, we summarized relationship between OS, neuroinflammation, addition, also particularly focused on antioxidants management

Language: Английский

Citations

124
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis DOI Creative Commons
Stefanie Grabrucker, Moira Marizzoni, Edina Silajdžić

et al.

Brain, Journal Year: 2023, Volume and Issue: 146(12), P. 4916 - 4934

Published: Oct. 18, 2023

Alzheimer's disease is a complex neurodegenerative disorder leading to decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor by showing specific alterations microbiome composition of patients rodent models. However, it unknown whether are causal manifestation symptoms. To understand involvement patient host physiology behaviour, we transplanted faecal from age-matched healthy controls into microbiota-depleted young adult rats. We found impairments behaviours reliant on hippocampal neurogenesis, essential process for certain memory functions mood, resulting transplants. Notably, severity correlated with clinical scores donor patients. Discrete changes rat caecal metabolome were also evident. As neurogenesis cannot be measured living humans but modulated circulatory systemic environment, assessed impact environment proxy readouts. Serum decreased human cells vitro associated key microbial genera. Our findings reveal first time, that symptoms can transferred organism via microbiota, confirming role disease, highlight converging central cellular regulating gut-mediated factors Alzheimer's.

Language: Английский

Citations

113
The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota DOI Open Access

Friedrich Leblhuber,

Daniela Ehrlich,

Kostja Steiner

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 361 - 361

Published: Jan. 25, 2021

The microbiota–gut–brain axis plays an important role in the development of neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence brain immune system function by production lipopolysaccharides amyloid. Dysbiosis intestinal microbiome induces local consecutively systemic immune-mediated inflammation. Proinflammatory cytokines then trigger neuroinflammation finally neurodegeneration. Immune-mediated oxidative stress lead to a deficiency vitamins essential micronutrients. Furthermore, wrong composition gut microbiota might impair intake metabolization nutrients. In patients with Alzheimer’s disease (AD) significant alterations have been demonstrated. Standard Western diet, infections, decreased physical activity chronic impact diversity microbiota. A higher abundancy “pro-inflammatory” goes along enhanced inflammation neuroinflammatory processes. Thus, AD beginning is closely related imbalance Modulation Mediterranean probiotics curcumin slow down cognitive decline alter significantly. multi-domain intervention approach addressing underlying causes (inflammation, metabolic like insulin resistance nutrient deficiency, stress) appears very promising reduce or even reverse exerting positive effects on

Language: Английский

Citations

108
The gut microbiota–brain axis in neurological disorder DOI Creative Commons
Hanif Ullah, Safia Arbab, Yali Tian

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 4, 2023

The gut microbiota (GM) plays an important role in the physiology and pathology of host. Microbiota communicate with different organs organism by synthesizing hormones regulating body activity. interaction central nervous system (CNS) signaling pathways includes chemical, neural immune endocrine routes. Alteration or dysbiosis leads to gastrointestinal tract disorders that ultimately impact host because abnormal microbial metabolites stimulate trigger physiologic reactions body. Intestinal a change bidirectional relationship between CNS GM, which is linked pathogenesis neurodevelopmental neurological disorders. Increasing preclinical clinical studies/evidence indicate microbes are possible susceptibility factor for progression disorders, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS) autism spectrum disorder (ASD). In this review, we discuss crucial connection system, biological systems contribution microbiota-related

Language: Английский

Citations

104
Inflammation, Lifestyle Factors, and the Microbiome‐Gut‐Brain Axis: Relevance to Depression and Antidepressant Action DOI Creative Commons
Francisco Donoso, John F. Cryan,

Loreto Olavarría‐Ramírez

et al.

Clinical Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 113(2), P. 246 - 259

Published: March 12, 2022

Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction complex biological components, such as immune system and microbiota‐gut‐brain axis. Adjunctive lifestyle‐oriented approaches for depression, including physical exercise special diets promising therapeutic options when combined with traditional antidepressants. However, mechanisms action these strategies incompletely understood. Accumulating evidence suggests that specific dietary regimens can modulate both gut microbiota composition. Here, we review current information about to alleviate their crosstalk inflammatory microbiome. We further discuss role axis possible mediator adjunctive therapies through mechanisms. Finally, future manipulate potential use exercise, interventions, prebiotics/probiotics, fecal transplantation.

Language: Английский

Citations

97