ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(51), P. 34720 - 34729
Published: Dec. 10, 2024
The
blood-spinal
cord
barrier
(BSCB)
tightly
regulates
the
transport
of
molecules
from
blood
to
spinal
cord.
Herein,
we
present
an
approach
for
transient
modulation
BSCB
permeability
and
localized
delivery
peptides
into
behavior
with
high
spatial
resolution.
This
utilizes
optical
stimulation
vasculature-targeted
nanoparticles
allows
BSCB-impermeable
without
significant
glial
activation
or
impact
on
animal
locomotor
behavior.
We
demonstrate
minimally
invasive
light
using
fiber
in
lumbar
region.
Our
method
bombesin,
a
centrally
acting
itch-inducing
peptide,
induces
rapid
increase
itching
behaviors
mice.
enables
genetic
modifications
is
promising
delivering
wide
range
biologics
potential
therapy
spatiotemporal
Annals of Medicine and Surgery,
Journal Year:
2024,
Volume and Issue:
87(3), P. 1360 - 1369
Published: Nov. 11, 2024
Schizophrenia
is
a
multifaceted
psychiatric
disorder
with
complex
etiology
that
includes
genetic,
environmental,
and
immunological
factors.
Emerging
research
has
increasingly
focused
on
the
role
of
immune
system,
particularly
neutrophils,
in
pathogenesis
schizophrenia.
Neutrophils,
most
abundant
type
white
blood
cells,
are
crucial
body’s
defense
mechanisms
against
infections
regulation
inflammation.
This
review
explores
evolving
evidence
implicates
neutrophils
schizophrenia,
highlighting
their
potential
contribution
to
disorder’s
onset
progression
through
such
as
neuroinflammation
oxidative
stress.
Recent
studies
have
demonstrated
elevated
neutrophil
counts
neutrophil-to-lymphocyte
ratios
(NLR)
individuals
correlating
severity
psychotic
symptoms
cognitive
impairments.
Furthermore,
genetic
molecular
analyses
revealed
abnormalities
function
immune-related
gene
expression
schizophrenia
patients.
These
findings
suggest
dysfunction
resulting
chronic
inflammation
could
play
significant
pathophysiology,
affecting
neuronal
function,
contributing
clinical
manifestations
Neutrophil-related
biomarkers,
NLR,
aid
diagnosis
monitoring
disease
progression.
Additionally,
targeting
activity
associated
inflammatory
pathways
presents
promising
avenue
for
developing
new
therapeutic
interventions.
underscores
need
further
elucidate
precise
by
which
influence
explore
treatments
improve
outcomes
Encyclopedia,
Journal Year:
2024,
Volume and Issue:
4(4), P. 1681 - 1699
Published: Nov. 18, 2024
The
central
nervous
system
(CNS)
relies
on
precise
regulation
of
potassium
ion
(K+)
concentrations
to
maintain
physiology.
This
involves
complex
cellular
and
molecular
mechanisms
that
work
in
concert
regulate
both
intracellular
extracellular
K+
levels.
Inflammation,
a
key
physiological
response,
encompasses
series
cell-specific
events
leading
inflammasome
activation.
Perturbations
K+-sensitive
processes
can
result
either
chronic
or
uncontrolled
inflammation,
highlighting
the
intricate
relationship
between
homeostasis
inflammatory
signalling.
review
explores
targets
influence
have
been
implicated
cascades,
offering
potential
therapeutic
avenues
for
managing
inflammation.
We
examine
common
across
different
cell
types,
providing
comprehensive
overview
interplay
inflammation
CNS.
By
elucidating
these
mechanisms,
we
identify
leads
drug
discovery
programmes
aimed
at
modulating
responses.
Additionally,
highlight
consequences
targeting
individual
entities
purposes,
emphasizing
need
nuanced
approach
developing
anti-inflammatory
strategies.
considers
current
knowledge
within
CNS,
critical
insights
into
underpinnings
interventions.
Our
findings
underscore
importance
considering
development
targeted
therapies
conditions
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
Vascular
dementia
(VaD)
refers
to
a
variety
of
dementias
driven
by
cerebrovascular
disease
and
is
the
second
leading
cause
globally.
VaD
may
be
caused
ischemic
strokes,
intracerebral
hemorrhage,
and/or
cerebral
small
vessel
disease,
commonly
identified
as
white
matter
hyperintensities
on
MRI.
The
mechanisms
underlying
these
lesions
in
periventricular
brain
are
poorly
understood.
In
this
study
we
perform
an
extensive
transcriptomic
analysis
human
postmortem
patients
with
goal
identifying
molecular
pathways
disease.
We
find
increased
cellular
stress
responses
astrocytes,
oligodendrocytes,
oligodendrocyte
precursor
cells
well
transcriptional
translational
repression
microglia
our
dataset.
show
that
several
genes
GWAS
being
associated
differentially
expressed
VaD.
Finally,
compare
dataset
independent
snRNAseq
PVWM
scRNAseq
iPSC-derived
exposed
oxygen
glucose
deprivation
(OGD).
identify
increase
heat
shock
protein
response
conserved
feature
across
celltypes
not
linked
OGD
exposure.
Overall,
first
common
lesioned
represent
potential
therapeutic
target.
Neuropsychiatric Disease and Treatment,
Journal Year:
2024,
Volume and Issue:
Volume 20, P. 2541 - 2552
Published: Dec. 1, 2024
This
study
aims
to
report
the
clinical,
biological,
and
imaging
features
of
cross-sectional
neurosyphilis
patients
with
leptomeningeal
enhancement
spinal
cord.
Here,
51
cord
positivity
are
described,
offering
a
promise
in
terms
early
diagnosis,
thereby
enabling
timely
detection
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(51), P. 34720 - 34729
Published: Dec. 10, 2024
The
blood-spinal
cord
barrier
(BSCB)
tightly
regulates
the
transport
of
molecules
from
blood
to
spinal
cord.
Herein,
we
present
an
approach
for
transient
modulation
BSCB
permeability
and
localized
delivery
peptides
into
behavior
with
high
spatial
resolution.
This
utilizes
optical
stimulation
vasculature-targeted
nanoparticles
allows
BSCB-impermeable
without
significant
glial
activation
or
impact
on
animal
locomotor
behavior.
We
demonstrate
minimally
invasive
light
using
fiber
in
lumbar
region.
Our
method
bombesin,
a
centrally
acting
itch-inducing
peptide,
induces
rapid
increase
itching
behaviors
mice.
enables
genetic
modifications
is
promising
delivering
wide
range
biologics
potential
therapy
spatiotemporal
