High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer’s Disease DOI Open Access
Christos Panagiotis Lisgaras, Helen E. Scharfman

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 2, 2023

ABSTRACT Interictal spikes (IIS) and seizures are well-documented in Alzheimer’s disease (AD). IIS typically outnumber seizures, supporting their role as a prominent EEG biomarker AD. In preclinical models, we showed that high frequency oscillations (HFOs>250Hz) also occur, but it is currently unknown how HFOs compare to IIS. Therefore, asked whether the incidence of differed if they differentially affected by behavioral state. We used three mouse lines simulate aspects AD: Tg2576, presenilin 2 knockout, Ts65Dn mice. recorded quantified hippocampus during wakefulness, slow-wave sleep, rapid eye movement sleep. all lines, were more frequent than High numbers correlated with fewer IIS, suggesting for first time possible competing dynamics among them Notably, occurred states summary, most abundant abnormality when compared states, better These findings pertained which important because different show may inhibit SHORT SUMMARY common occur earlier stages. comparison between lacking. Here 3 AD features local field potential recordings quantify HFOs. found outnumbered total inversely abnormality, this was generalizable across types

Language: Английский

Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease DOI
Inna Slutsky

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 272 - 284

Published: Feb. 19, 2024

Language: Английский

Citations

13
PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application DOI Creative Commons
Yipeng Zhang, Lawrence Liu, Yuanyi Ding

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(3), P. 036023 - 036023

Published: May 9, 2024

. This study aims to develop and validate an end-to-end software platform, PyHFO, that streamlines the application of deep learning (DL) methodologies in detecting neurophysiological biomarkers for epileptogenic zones from EEG recordings.

Language: Английский

Citations

5
The role of electroencephalography in epilepsy research—From seizures to interictal activity and comorbidities DOI Creative Commons
Christos Panagiotis Lisgaras, Liset Menéndez de la Prida, Edward H. Bertram

et al.

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both basic and translational studies. Its contributions have advanced our understanding of epilepsy, shedding light on pathophysiology functional organization epileptic networks, mechanisms underlying seizures. Here we re‐examine historical significance, ongoing relevance, future trajectories EEG research. We describe traditional approaches to record brain electrical activity discuss novel cutting‐edge, large‐scale techniques using micro‐electrode arrays. Contemporary studies explore potentials beyond Berger frequencies uncover underexplored operating at ultra‐slow high frequencies, which proven valuable principles ictogenesis, epileptogenesis, endogenous epileptogenicity. Integrating with modern such as optogenetics, chemogenetics, imaging provides a more comprehensive epilepsy. become an integral element powerful suite tools capturing network dynamics across various temporal spatial scales, ranging from rapid pathological synchronization long‐term processes epileptogenesis or seizure cycles. Advancements recording parallel application sophisticated mathematical analyses algorithms, significantly augmenting information yield recordings. Beyond seizures interictal activity, elucidating epilepsy‐related cognitive deficits other comorbidities. Although remains cornerstone research, persistent challenges limited resolution, artifacts, difficulty highlight need refinement. Despite these challenges, continues be fundamental tool, playing central role unraveling disease drug discovery.

Language: Английский

Citations

0
Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans DOI Open Access
Anna Maslarova, Jiyun N. Shin, Andrea Navas-Olivé

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly distinct IEDs. In 1024-channel recordings APP/PS1 mice, SPW-Rs were distinguishable IEDs narrow the CA1 pyramidal layer, narrowband frequency peaks, multiple ripple cycles unfiltered local field potential. epilepsy patients, showed similar peaks visible subiculum but absent dentate gyrus. Conversely, a broad extent wide-band power. introduce semi-automated, detection toolbox (“ripmap”) selecting optimal channels separating event waveforms low-dimensional embedding. Our approach improves accuracy, providing firm foundation future research.

Language: Английский

Citations

0
The Bidirectional Relationship Between Epilepsy and Alzheimer’s Disease DOI
David Stewart, Emily L. Johnson

Current Neurology and Neuroscience Reports, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 8, 2025

Language: Английский

Citations

0
Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence DOI
Paige Anton, Nicole Maphis, David N. Linsenbardt

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 242

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms of the Pathogenesis of Alzheimer’s Disease: The Role of the Basal Forebrain DOI
Valentina Kitchigina, I. Yu. Popova, Liubov Shubina

et al.

Neuroscience and Behavioral Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity DOI Creative Commons
Eric R. Cole, Thomas E. Eggers, David Weiß

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(3), P. 036039 - 036039

Published: June 1, 2024

. Therapeutic brain stimulation is conventionally delivered using constant-frequency pulses. Several recent clinical studies have explored how unconventional and irregular temporal patterns could enable better therapy. However, it challenging to understand which are most effective for different therapeutic applications given the massively high-dimensional parameter space.

Language: Английский

Citations

3
Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity DOI
Jinquan Li, Yanjun Liu,

Chuhui Yin

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102468 - 102468

Published: Aug. 31, 2024

Language: Английский

Citations

3
Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease DOI Creative Commons
Elissavet Chartampila, Karim S. Elayouby, Paige Leary

et al.

eLife, Journal Year: 2024, Volume and Issue: 12

Published: June 21, 2024

Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, the effects of MCS on neuronal hyperexcitability AD are unknown. We investigated a well-established mouse model with hyperexcitability, Tg2576 mouse. The most common type mice generalized EEG spikes (interictal [IIS]). IIS also other models and occur patients. In models, is reflected by elevated expression transcription factor ∆FosB granule cells (GCs) dentate gyrus (DG), which principal cell type. Therefore, we studied ΔFosB GCs. marker NeuN within hilar neurons DG because reduced protein sign oxidative stress or pathology. This potentially important regulate GC excitability. breeding pairs received diet relatively low, intermediate, high concentration choline. After weaning, all intermediate diet. offspring fed diet, frequency declined, was reduced, restored. Using novel object location task, spatial memory improved. contrast, exposed to low had several adverse effects, such as increased mortality. They weakest immunoreactivity greatest expression. their surprising. results provide new evidence that early life can improve outcomes AD, have mixed effects. first study showing dietary neurons, ΔFosB, an animal AD.

Language: Английский

Citations

2