Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease DOI Creative Commons

Shuangshuang Dong,

Bo Shen, Xu Jiang

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 5, 2024

The vagus nerve (VN) is the main neural pathway linking gut and brain in Parkinson's disease (PD). In this study, we utilized high-resolution ultrasound to measure VN cross-sectional area (CSA) 96 healthy controls (HCs) 75 PD patients. group was further categorized into three subgroups: PD-preRBD, PD-postRBD, PD-nonRBD. PD-preRBD body-first subtype, PD-postRBD PD-nonRBD were brain-first subtype. had a significantly lower CSA than HCs. Subgroup analysis revealed that tended exhibit smaller both groups. CSA, specifically right VN, correlated with subtype some components of PD-related assessment scales. Overall, these findings provide evidence atrophy PD, especially suggesting could serve as an adjunctive diagnostic tool.

Language: Английский

The association between the health of the intestines and the human body with Akkermansia muciniphila DOI Creative Commons

Seyed Ali Sadr Tabatabaei,

Hedie Yousefi Ghadim,

Sara Alaei

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100352 - 100352

Published: April 1, 2025

Language: Английский

Citations

0
Exploratory Analysis of Gut Microbiota Profile in Duchenne Muscular Dystrophy (DMD) Patients with Intellectual Disability DOI Creative Commons
Chiara Panicucci, Sara Casalini, Giovanni Fiorito

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract This study investigates the differences in gut microbiota composition between DMD patients with (DMD +) and without −) intellectual disability (ID) its potential role cognitive outcomes. In this study, we assessed 50 genetically confirmed (median age 13.1 years) using 16S rRNA gene sequencing. Cognitive assessment was performed Wechsler Intelligence Scales, ID defined as an IQ < 70. Stool samples were analyzed, statistical methods used to assess alpha- beta-diversity. Thirty-four percent of had ID. No significant found alpha-diversity or Firmicutes/Bacteroidetes ratio. However, beta-diversity analysis revealed + − groups, including, , increased abundance Propionibacterium Bifidobacterium a reduction Bulleidia . These bacteria are involved metabolic pathways that can influence neurological health through gut-brain axis, particularly via production short-chain fatty acids. While these preliminary findings suggest possible association profile impairment DMD, further research is needed explore causal relationship consider microbiota-targeted therapeutic strategies.

Language: Английский

Citations

0
Gastric emptying time and its correlation with cardiac MIBG in body-first and brain-first subtype Parkinson’s disease DOI
Min Seung Kim, Don Gueu Park, In Ja Shin

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 272(1)

Published: Dec. 12, 2024

Language: Английский

Citations

1
Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression DOI Creative Commons
Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(12), P. 3416 - 3429

Published: Dec. 16, 2024

Parkinson’s disease has long been considered a disorder that primarily affects the brain, as it is defined by dopaminergic neurodegeneration in substantia nigra and brain accumulation of Lewy bodies containing α-synuclein protein. In recent decades, however, accumulating research revealed also involves gut uncovered an intimate important bidirectional link between gut, called “gut–brain axis.” Numerous clinical studies demonstrate dysfunction frequently precedes motor symptoms patients, with findings including impaired intestinal permeability, heightened inflammation, distinct microbiome profiles metabolites. Furthermore, deposition consistently observed suggesting potential role initiation. Importantly, individuals vagotomy have reduced risk. From these observations, researchers hypothesized may initiate subsequently propagate to central neurons through gut–brain axis, leading disease. This review comprehensively examines gut’s involvement disease, focusing on concept gut-origin for We examine interplay altered gut-related factors pathological patients. Given accessibility both dietary pharmacological interventions, targeting gut-localized represents promising avenue developing effective therapies.

Language: Английский

Citations

0
Exploring the relationship betweenGBA1host genotype and gut microbiome in theGBA1L444P/WTmouse model: Implications for Parkinson disease pathogenesis DOI Creative Commons
Elisa Menozzi,

Mallia Geiger,

Victoria Meslier

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Background Heterozygous variants in GBA1 are the commonest genetic risk factor for Parkinson disease (PD) but penetrance is incomplete. dysfunction can cause gastrointestinal disturbances and microbiome changes preclinical models. Mounting evidence suggests that microbiota-gut-brain axis potentially implicated PD pathogenesis. Whether gut composition influenced by host genetics heterozygosis has never been explored. Objectives To evaluate whether heterozygosity pathogenic L444P variant perturbations composition. Methods Faecal samples collected from L444P/WT WT/WT mice at 3 6 months of age were analysed through shotgun metagenomic sequencing. Results No differences α- β-diversity detected between genotyped groups, either time points. Overall, we found a little variation functional potential over time. Conclusion Host genotype does not impact structure presented mouse model. Studies investigating effect second hit on physiology could explain partial PD.

Language: Английский

Citations

0
Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease DOI Creative Commons

Shuangshuang Dong,

Bo Shen, Xu Jiang

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 5, 2024

The vagus nerve (VN) is the main neural pathway linking gut and brain in Parkinson's disease (PD). In this study, we utilized high-resolution ultrasound to measure VN cross-sectional area (CSA) 96 healthy controls (HCs) 75 PD patients. group was further categorized into three subgroups: PD-preRBD, PD-postRBD, PD-nonRBD. PD-preRBD body-first subtype, PD-postRBD PD-nonRBD were brain-first subtype. had a significantly lower CSA than HCs. Subgroup analysis revealed that tended exhibit smaller both groups. CSA, specifically right VN, correlated with subtype some components of PD-related assessment scales. Overall, these findings provide evidence atrophy PD, especially suggesting could serve as an adjunctive diagnostic tool.

Language: Английский

Citations

0