Efficiency of Melissa officinalis leaf extract in amelioration of oxidative status and histological changes in male albino rats with induced hypothyroidism DOI Creative Commons

Zainab Naeif Majeed,

Abbas Abed Sharhan

Regulatory Mechanisms in Biosystems, Journal Year: 2024, Volume and Issue: 15(4), P. 985 - 991

Published: Dec. 16, 2024

The study was conducted to demonstrate the role of ethanolic leavf extract from Melissa officinalis in treatment hypothyroidism disease which induced by drug carbimazole. aim this investigate effects oral administration M. on oxidative status and histological changes rats with hypothyroidism. Fifty male were divided into five groups, ten for each. Group I selected as negative control administered orally normal saline alone, group II served positive tadministered carbimazole (5 mg/kg) anti-thyroid six weeks induce III hypothyroidism, then treated plant (75 mg/day). IV (150 mg/day) V thyroxin (50 µg). results showed that there no significant difference MDA levels third when compared groups I, while a decrease II. differences SOD V, increase thyroid gland an irregular shape colloids thickening epithelial cells uneven distribution thyroglobulin (some appeared full others empty) slight infiltration inflammatory apoptosis structure gland, result demonstrated repair III, looked same group. In liver section group, hepatocytes arranged irregularly around central vein, addition presence material cells, well hepatocytes, return Also cells. On other hand, renal nephrons severe lymphocytes, hemorrhage tubules, revealed control. conclusion, leaves regulate rats. It alleviated response suppressing increasing groups. These might strengthen protective effect rat model

Language: Английский

Predictive Effect of FT3 Within the Euthyroid Range on LDL‐C in Patients With Type 2 Diabetes: A Cross‐Sectional Analysis of Inpatients in China DOI Open Access
Yujue Wang, Chi Zhang, Sihai Zhao

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2025, Volume and Issue: 52(3)

Published: Jan. 9, 2025

Evidence regarding the relationship between free triiodothyronine (FT3) and low-density lipoprotein cholesterol (LDL-C) remains limited. This study aimed to evaluate association FT3 LDL-C levels in patients with type 2 diabetes mellitus (T2DM) who exhibit normal thyroid function. Between June 2022 October 2023, a total of 3011 inpatients T2DM euthyroid status were continuously non-selectively recruited from Chinese hospital. The average age included individuals was 56.92 ± 12.56 years, 1430 (47.49%) males. mean concentration 4.35 0.56 pmol/L. A logistic regression model applied analyse levels, while smooth curve fitting employed investigate potential nonlinear associations these variables. demonstrated positive correlation (0.05 [95% CI: 0.02-0.07; p = 0.0018]) (p 0.0014) diabetes. Specifically, when below 4.28 pmol/L, increased alongside rising concentration. However, reached or exceeded plateaued tended stabilise. These findings suggest that maintaining within range 2.76 pmol/L may be most beneficial for mitigating progression cardiovascular disease T2DM. Our research is important identifying optimal delay provide valuable insights guide clinicians preventing managing this population.

Language: Английский

Citations

0
Influence of levothyroxine replacement on metabolic dysfunction-associated steatotic liver disease and dyslipidemia in subclinical hypothyroidism: insights from a randomized controlled study DOI Creative Commons
Zainab Gaber Mahran, Samira Osman,

Amira Abdelmawgod

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 10, 2025

Abstract Background In recent years, there has been growing awareness of metabolic dysfunction-associated steatotic liver disease (MASLD) linked to hypothyroidism. However, insufficient data exists on how levothyroxine (LT4) replacement therapy impacts MASLD. We aimed assess the effects LT4 treatment dyslipidemia and MASLD in patients with subclinical hypothyroidism (SCH). Methods a randomized, controlled study, 230 were screened for SCH, 182 diagnosed SCH. Of these, 30 had significant SCH 152 mild All received (significant SCH-LT4), while those divided into two groups: 50 (mild SCH-LT4) 102 did not SCH-control). Results Significant improvements hepatic steatosis severity observed treated groups compared control. After treatment, prevalence decreased 50% ( p = 0.001) SCH-LT4 group 60% 0.025) group. SCH-control group, improved slightly but non-significantly from 100 75% 0.164). Compared other groups, showed greater parameters, including weight, body mass index, total cholesterol, high-density lipoprotein C-reactive protein, emphasizing notable impact levothyroxine. Conclusion This study highlights that can significantly improve MASLD, dyslipidemia, systemic inflammation particularly These findings support clinical use thyroxine managing patients.

Language: Английский

Citations

0
Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process? DOI Creative Commons
Laura Sabatino, Cristina Vassalle

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 361 - 361

Published: March 2, 2025

Thyroid hormones (THs) are important modulators of many metabolic processes, being strictly associated with the control energy balance, mainly through activities on brain, white and brown adipose tissue, skeletal muscle, liver, pancreas. In this review, principal mechanisms TH regulation processes will be discussed THs’ relevance in disease progression evaluated, especially cardiovascular context correlated diseases. Moreover, we discuss regulatory role events a special focus process “browning”, which consists gradual acquisition by adipocytes physical functional characteristics adipocytes. The advancements research molecular proposed physiopathological discussed.

Language: Английский

Citations

0
Predictive Effect of FT3 Within the Euthyroid Range on HDL‐C in Patients With Type 2 Diabetes: A Cross‐Sectional Analysis of Inpatients in China DOI Creative Commons

Jinmei Xu,

Sihai Zhao, Yan Wang

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT Background Evidence for assessing the relationship between free triiodothyronine (FT3) and high‐density lipoprotein cholesterol (HDL‐C) remains limited. Therefore, purpose of our study is to evaluate FT3 HDL‐C in patients with type 2 diabetes. Methods From June 2022 October 2023, 3011 normal thyroid function diagnosed diabetes mellitus (T2DM) were collected continuously non‐selectively a Chinese hospital. Then, we used logistic regression model explore HDL‐C. Smooth curve fitting identify nonlinear Results After adjusting influence relevant factors, negatively correlated −0.02 (−0.04, −0.00; p = 0.0162). There also HDL‐C, an inflection point 3.48 pmol/L (P log‐ likelihood ratio test 0.044). Conclusion This shows that there negative correlation population When 2.76–3.48 pmol/L, tends stable state; 3.48–6.45 decreases increase concentration (According reference range by hospital, value serum 2.76–6.45 pmol/L). These findings suggest maintaining within 2.76 may be most beneficial mitigating progression cardiovascular disease T2DM.

Language: Английский

Citations

0
Exploring the relationships between prenatal phthalate exposure and neonatal thyroid function: A prospective cohort study DOI
Zhifang Xiong, Gaga Mahai, Aizhen Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138132 - 138132

Published: April 1, 2025

Language: Английский

Citations

0
Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases” DOI Creative Commons
Kenji Hashimoto, Wei Yan, Chun Yang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106666 - 106666

Published: Sept. 1, 2024

Language: Английский

Citations

2
Application of Human Plasma Targeted Lipidomics and Analysis of Toxic Elements to Capture the Metabolic Complexities of Hypothyroidism DOI Creative Commons
Anna Błażewicz, Michał Kiełbus, Katarzyna Skórzyńska-Dziduszko

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5169 - 5169

Published: Oct. 31, 2024

Hypothyroidism (HT) affects millions worldwide and can lead to various lipid disorders. The metabolic complexity the influence of toxic elements in autoimmune non-autoimmune HT subtypes are not fully understood. This study aimed investigate relationships between plasma lipidome, elements, clinical classifications unexposed individuals.

Language: Английский

Citations

1
Efficiency of Melissa officinalis leaf extract in amelioration of oxidative status and histological changes in male albino rats with induced hypothyroidism DOI Creative Commons

Zainab Naeif Majeed,

Abbas Abed Sharhan

Regulatory Mechanisms in Biosystems, Journal Year: 2024, Volume and Issue: 15(4), P. 985 - 991

Published: Dec. 16, 2024

The study was conducted to demonstrate the role of ethanolic leavf extract from Melissa officinalis in treatment hypothyroidism disease which induced by drug carbimazole. aim this investigate effects oral administration M. on oxidative status and histological changes rats with hypothyroidism. Fifty male were divided into five groups, ten for each. Group I selected as negative control administered orally normal saline alone, group II served positive tadministered carbimazole (5 mg/kg) anti-thyroid six weeks induce III hypothyroidism, then treated plant (75 mg/day). IV (150 mg/day) V thyroxin (50 µg). results showed that there no significant difference MDA levels third when compared groups I, while a decrease II. differences SOD V, increase thyroid gland an irregular shape colloids thickening epithelial cells uneven distribution thyroglobulin (some appeared full others empty) slight infiltration inflammatory apoptosis structure gland, result demonstrated repair III, looked same group. In liver section group, hepatocytes arranged irregularly around central vein, addition presence material cells, well hepatocytes, return Also cells. On other hand, renal nephrons severe lymphocytes, hemorrhage tubules, revealed control. conclusion, leaves regulate rats. It alleviated response suppressing increasing groups. These might strengthen protective effect rat model

Language: Английский

Citations

0