Brain Atrophy Is Associated with Hematoma Expansion in Intracerebral Hemorrhage, Depending on Coagulation Status DOI Open Access
Anna Speth, Andrea Dell’Orco, Justus F. Kleine

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2227 - 2227

Published: March 25, 2025

Background/Objectives: This study aimed to research the potential association between brain atrophy and hematoma expansion (HE) in intracerebral hemorrhage (ICH). Methods: A retrospective analysis was conducted using data from patients with primary ICH our stroke database. volumes initial follow-up CT scans were manually segmented. Total intracranial quantified an automated head segmentation method. Normalized volume (NBV) calculated by dividing total account for individual size differences. The relationship NBV assessed linear regression, adjusting other variables influencing expansion. Results: Our final included 420 patients. Brain (lower NBV) associated growth (>0 mL) not on oral anticoagulants (β = -0.159, p 0.032). strong observed vitamin K antagonists -0.667, 0.006) but those direct (DOACs; 0.436)). Results remained significant VKAs when defined as a increase >6 mL or >33%. Conclusions: provides evidence that is risk factor expansion, depending patient's coagulation status. These findings could enhance stratification acute clinical management deepen understanding of biological mechanisms behind

Language: Английский

Brain Atrophy Is Associated with Hematoma Expansion in Intracerebral Hemorrhage, Depending on Coagulation Status DOI Open Access
Anna Speth, Andrea Dell’Orco, Justus F. Kleine

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2227 - 2227

Published: March 25, 2025

Background/Objectives: This study aimed to research the potential association between brain atrophy and hematoma expansion (HE) in intracerebral hemorrhage (ICH). Methods: A retrospective analysis was conducted using data from patients with primary ICH our stroke database. volumes initial follow-up CT scans were manually segmented. Total intracranial quantified an automated head segmentation method. Normalized volume (NBV) calculated by dividing total account for individual size differences. The relationship NBV assessed linear regression, adjusting other variables influencing expansion. Results: Our final included 420 patients. Brain (lower NBV) associated growth (>0 mL) not on oral anticoagulants (β = -0.159, p 0.032). strong observed vitamin K antagonists -0.667, 0.006) but those direct (DOACs; 0.436)). Results remained significant VKAs when defined as a increase >6 mL or >33%. Conclusions: provides evidence that is risk factor expansion, depending patient's coagulation status. These findings could enhance stratification acute clinical management deepen understanding of biological mechanisms behind

Language: Английский

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