A life course approach to neurodegeneration DOI
Sarah‐Naomi James, Jonathan M. Schott, Yoav Ben–Shlomo

et al.

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 209 - 228

Published: Feb. 20, 2025

Abstract Neurodegenerative diseases typically have their onset in later life and reflect varying combinations of genetic risk course exposures. In this chapter, we consider the contribution that epidemiological approaches can make to our understanding neurodegenerative disorders, with particular reference Alzheimer’s disease Parkinson’s disease. These two diseases, as well others, are characterized by accumulation misfolded proteins within central nervous system leading neuronal cell death. Conceptual issues discussed, including reserve resilience, methodological challenges determining for where vivo diagnosis is imprecise time between potential exposures manifestations may be many decades. Evidence linking conditions presented, a focus on diverse populations implications prevention strategies.

Language: Английский

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency DOI Creative Commons
Ricardo Lagoa, Rajan Logesh,

Cristiana Violante

et al.

Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108568 - 108568

Published: March 1, 2025

Language: Английский

Citations

0
A life course approach to neurodegeneration DOI
Sarah‐Naomi James, Jonathan M. Schott, Yoav Ben–Shlomo

et al.

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 209 - 228

Published: Feb. 20, 2025

Abstract Neurodegenerative diseases typically have their onset in later life and reflect varying combinations of genetic risk course exposures. In this chapter, we consider the contribution that epidemiological approaches can make to our understanding neurodegenerative disorders, with particular reference Alzheimer’s disease Parkinson’s disease. These two diseases, as well others, are characterized by accumulation misfolded proteins within central nervous system leading neuronal cell death. Conceptual issues discussed, including reserve resilience, methodological challenges determining for where vivo diagnosis is imprecise time between potential exposures manifestations may be many decades. Evidence linking conditions presented, a focus on diverse populations implications prevention strategies.

Language: Английский

Citations

0