Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 219, P. 115965 - 115965
Published: Dec. 2, 2023
Language: Английский
International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(9), P. 2879 - 2896
Published: Jan. 1, 2023
Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D, DHCR7, IDI1/2. Especially, and EBP promising therapeutic targets drug development due to many drugs have been approved entered into clinical research by targeting these genes. However, new still need be discovered. Interestingly, small nucleic acid vaccines were the market, Inclisiran, Patisiran, Inotersen, Givosiran, Lumasiran, Nusinersen, Volanesorsen, Eteplirsen, Golodirsen, Viltolarsen, Casimersen, Elasomeran, Tozinameran. agents all linear RNA agents. Circular RNAs (circRNAs) may longer half-lives, higher stability, lower immunogenicity, production costs, delivery efficiency than their covalently closed structures. CircRNA developed several companies, Orna Therapeutics, Laronde, CirCode, Therorna. studies shown that circRNAs regulate synthesis regulating ACS, YWHAG, PTEN, SREBP-2, PMK expression. MiRNAs essential circRNA-mediated biosynthesis. Notable, phase II trial inhibiting miR-122 with has completed. Suppressing circRNA_ABCA1, circ-PRKCH, circEZH2, circRNA-SCAP, circFOXO3 target development, specifically circFOXO3. This review focuses on mechanism of circRNA/miRNA axis hope providing knowledge identify targets.
Language: Английский
Citations
40
Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(12), P. 1231 - 1245
Published: Nov. 27, 2023
Introduction Lipid-laden foam cells within atherosclerotic plaques are key players in all phases of lesion development including its progression, necrotic core formation, fibrous cap thinning, and eventually plaque rupture. Manipulating cell biology is thus an attractive therapeutic strategy at early, middle, even late stages atherosclerosis. Traditional therapies have focused on prevention, especially lowering plasma lipid levels. Despite these interventions, atherosclerosis remains a major cause cardiovascular disease, responsible for the largest numbers death worldwide.
Language: Английский
Citations
17
Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(8), P. 6682 - 6700
Published: Aug. 13, 2023
Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to class of non-coding arise as result non-canonical splicing premature RNA, which results formation closed single-stranded circRNA molecules lack 5′-end caps 3′-end poly(A) tails. circRNAs broad post-transcriptional regulatory activity. Acting sponge for miRNAs, compete with mRNAs binding acting competing endogenous RNAs. Numerous are involved circRNA–miRNA–mRNA axes associated pathogenesis cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, disease. Recent сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, circ_0003423 disease (CAD) an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, circ_0050486 possess proatherogenic effect. With their high resistance endonucleases, promising diagnostic biomarkers therapeutic targets. This review aims provide updated information on involvement atherogenesis-related CAD. We also discuss main modern approaches detecting studying interactions, well prospects using targets treatment
Language: Английский
Citations
10
International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 1047 - 1073
Published: Feb. 1, 2025
Atherosclerosis, a progressive inflammatory disease of the arteries, remains leading cause cardiovascular morbidity and mortality worldwide. Recent years have witnessed pivotal role N6-methyladenosine (m6A) RNA methylation in regulating various biological processes, including those implicated atherosclerosis. Current evidence suggested that m6A regulators (writers, erasers, readers) participated modification multiple non-coding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), thereby affecting their metabolism functions. Meanwhile, ncRNAs also emerged as key modulator expression turn. Therefore, understanding mutual regulation between modifications is great significance to identify novel therapeutic targets for atherosclerosis has clinical application prospects. This review aims summarize recent advances reciprocal provide insights into interaction context
Language: Английский
Citations
0
Molecular Genetics Microbiology and Virology (Russian), Journal Year: 2025, Volume and Issue: 43(1), P. 24 - 24
Published: April 10, 2025
The aim. aim of this work is to evaluate the expression circRNA circLDLR, circSPARC, circSMARCA5 and circTMEM181, mediated targets which are mRNAs genes associated with atherogenesis. This study may provide updated information on involvement atherogenesis in pathogenesis coronary heart disease, as well suggest possible prospects for their use biomarkers therapeutic treatment cardiovascular diseases. Material methods. included 68 patients artery stenosis 41 control without atherosclerosis confirmed by angiography. Using real-time PCR, we measured levels circSMARCA5, circTMEM181 RNA preparations isolated from peripheral blood mononuclear cells. Results discussion. An increase circSPARC disease compared confirms pro-atherogenic effect. Conclusion. Has been suggested potential significance diagnosis atherosclerosis.
Language: Английский
Citations
0
Cancer Communications, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an involved in carcinogenesis, has been associated with evasion and energy metabolism reprogramming. This study aimed examine the molecular mechanisms underlying involvement of NSUN2 metabolic reprogramming HCC. Methods Single‐cell transcriptomic sequencing was applied cellular composition changes, particularly cell dynamics, HCC adjacent normal tissues. Bulk RNA‐seq proteomics identified key genes proteins. Methylation methylated immunoprecipitation (MeRIP) were carried out characterize role 5‐methylcytosine (m5C) modification sterol O‐acyltransferase ( SOAT2 ). Clinical samples from 30 patients analyzed using reverse transcription‐quantitative polymerase chain reaction Western blotting. Gene expression manipulated CRISPR/Cas9 lentiviral vectors. In vitro co‐culture models metabolomics used cell‐T interactions, metabolism, evasion. Tumor growth orthotopic mouse model monitored by bioluminescence imaging, subsequent measurements tumor weight, volume, immunohistochemical staining. Results analysis marked increase malignant cells Cell communication indicated that might promote cancer progression evading clearance. Multi‐omics analyses as regulator development. MeRIP confirmed facilitated m5C . Analysis human tissue demonstrated pronounced upregulation , along elevated levels experiments uncovered augmented repressed activity cytotoxicity CD8 + T cells, contributing vivo studies further substantiated fostering formation modulating Conclusions The findings highlight critical driving through regulation on These present potential markers diagnosis therapeutic targets treatment.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156743 - 156743
Published: April 17, 2025
Language: Английский
Citations
0
The Tohoku Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 263(2), P. 123 - 131
Published: Jan. 1, 2024
The relationships of serum circNIPSNAP3A and circHIPK3 with metabolic disorders, atherosclerosis severity coronary artery disease (CAD) remain to be clarified.Three hundred thirty-eight subjects were categorized into normal artery, CAD groups.Clinical data including anthropometric indexes, medical history, physiological biochemical parameters collected.Serum determined by quantitative real-time PCR.CAD was evaluated clinical manifestation, electrocardiogram angiography.Both groups had a higher level than the group (P < 0.05 for all).The high percentage (> 66th percentile) mean levels triglycerides, uric acid homocysteine, lower high-density lipoprotein cholesterol apolipoprotein AI those low (< 33th circNIPSNAP3A.Notably, is significantly independently associated CAD, more diseased branches incidence acute syndrome circNIPSNAP3A.Regarding circHIPK3, medium or but no significant differences in among 33rd, 33rd-66th, > percentiles detected.Serum related cardiovascular risk factors severity, may potential prognostic marker and/or therapeutic target CAD.
Language: Английский
Citations
3
Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 55, P. 101518 - 101518
Published: May 1, 2025
Language: Английский
Citations
0
Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 219, P. 115965 - 115965
Published: Dec. 2, 2023
Language: Английский
Citations
3