MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice DOI
Geetika Bajaj,

Diksha Choudhary,

Vishal Singh

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Metabolic disorders such as Type 2 diabetes mellitus (T2DM) imposes a significant global health burden. Plant‐derived exosome like nanoparticles (P‐ELNs) have emerged promising therapeutic alternate for various diseases. Present data demonstrates that treatment with Ginger‐derived (G‐ELNs) enhance insulin dependent glucose uptake, downregulate gluconeogenesis and oxidative stress in resistant HepG2 cells. Furthermore, oral administration of G‐ELNs T2DM mice decreases fasting blood levels improves tolerance effectively metformin. These improvements are attributed to the enhanced phosphorylation Protein kinase B (Akt‐2), phosphatidylinositol 3‐kinase at serine 474 which consequently leads increase hepatic sensitivity, improvement homeostasis decrease ectopic fat deposition. Oral also exerts protective effect on Streptozotocin (STZ)‐induced pancreatic β‐cells damage, contributing systemic amelioration T2DM. Further, per computational tools, miRNAs present modulate (PI3K)/Akt‐2 pathway exhibit strong interactions target mRNAs responsible gluconeogenesis, deposition stress. synthetic mimic miRNA downregulates its mRNA Overall, results indicate metabolism thus, exerting effects

Language: Английский

Mesenchymal stem cell-derived extracellular vesicles: A promising therapeutic strategy in diabetic osteoporosis DOI
Yajing Yang,

Xi-Er Chen,

Xuchang Zhou

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(12), P. 2399 - 2403

Published: Nov. 14, 2024

Diabetic osteoporosis (DOP) is a serious complication of diabetes mellitus. It urgent to explore efficient clinical treatment strategies for DOP. has been found that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), as an emerging cell-free therapy, show great potential in DOP treatment. MSC-EVs can effectively promote bone formation, inhibit resorption, and modulate the inflammatory microenvironment by delivering cargoes microRNAs, long non-coding RNAs, proteins target cells, thereby ameliorating loss However, there are limited reports on with MSC-EVs. To evoke more attention this strategy, article summarised extant literature provide new directions further research application management

Language: Английский

Citations

0
MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice DOI
Geetika Bajaj,

Diksha Choudhary,

Vishal Singh

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Metabolic disorders such as Type 2 diabetes mellitus (T2DM) imposes a significant global health burden. Plant‐derived exosome like nanoparticles (P‐ELNs) have emerged promising therapeutic alternate for various diseases. Present data demonstrates that treatment with Ginger‐derived (G‐ELNs) enhance insulin dependent glucose uptake, downregulate gluconeogenesis and oxidative stress in resistant HepG2 cells. Furthermore, oral administration of G‐ELNs T2DM mice decreases fasting blood levels improves tolerance effectively metformin. These improvements are attributed to the enhanced phosphorylation Protein kinase B (Akt‐2), phosphatidylinositol 3‐kinase at serine 474 which consequently leads increase hepatic sensitivity, improvement homeostasis decrease ectopic fat deposition. Oral also exerts protective effect on Streptozotocin (STZ)‐induced pancreatic β‐cells damage, contributing systemic amelioration T2DM. Further, per computational tools, miRNAs present modulate (PI3K)/Akt‐2 pathway exhibit strong interactions target mRNAs responsible gluconeogenesis, deposition stress. synthetic mimic miRNA downregulates its mRNA Overall, results indicate metabolism thus, exerting effects

Language: Английский

Citations

0