Long noncoding RNA HSCHARME promotes the maturation of stem cells-derived cardiomyocytes by controlling gene regulatory networks altered in human cardiomyopathies DOI Creative Commons
Giulia Buonaiuto, Fabio Desideri,

Giulio Storari

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT A growing body of evidence suggests that tissue-specific long noncoding RNAs (lncRNA) play pivotal roles in the heart. Here, we exploited synteny between mouse and human genomes to identify novel lncRNA HSCHARME ( H uman S yntenic CHARME ) combined single-cell transcriptomics, CAGE-seq data, RNA-FISH imaging CRISPR-Cas9 genome editing document its role cardiomyogenesis. We found functional inactivation hiPSC-derived cardiomyocytes (CM) impairs expression calcium handling contraction genes, with a consequent decline CM maturation contractile functions. Consistent possible association disease, large-scale analysis across cardiomyopathy patients revealed increased levels hypertrophic (HCM) dilated (DCM) hearts identified subset diseased-associated targets whose can be modulated through dosage. Overall, our data unlock potential as non-coding regulator physiology open new possibilities for therapeutic application disease.

Language: Английский

Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review DOI Creative Commons
Shangwu Liu,

Runhong Zhang,

Jamal Hallajzadeh

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 7, 2025

Abstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related the deterioration nervous system. Non-coding RNAs (ncRNAs) and exosomal ncRNAs associated with vesicles been recognized influencers gene expression cell signaling, potentially contributing positive impact physical neurodegenerative conditions. It is hypothesized that exercise-induced changes ncRNA may regulate key processes involved neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, synaptic function. Exercise shown promise preventing diseases (NDs), are emerging potential mediators these benefits. In review, we explored how play a role enhancing impacts disorders for future treatments. Research studies, both preclinical clinical, documented use various exercises their treatment NDs compiled enlisted from PubMed database, spanning time period year 2000 up current time. Studies show manipulating specific or harnessing cargo could be utilized therapeutic strategies treating NDs. conclusion, studies suggest exercise modalities, aerobic, resistance, high-intensity interval training, can modulate context The altered profiles contribute neuroprotective observed interventions. However, more research needed fully understand underlying mechanisms further explore signatures biomarkers targets disorders.

Language: Английский

Citations

2
A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine DOI Creative Commons
R.A. Youness,

Hossam A. Hassan,

Tasneem Abaza

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1245 - 1245

Published: July 24, 2024

Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors oncogenes different oncological contexts, including hepatocellular carcinoma (HCC). Their significantly impact the disease at all stages, initiation, development, progression, invasion, metastasis, addition to response treatment. In this review, we discuss biogenesis regulatory functional of circRNAs, well circRNA-protein-mRNA ternary complex formation, elucidating intricate pathways tuned by circRNAs modulate gene expression cellular processes through a comprehensive literature search, silico bioinformatics analysis. With particular focus on interplay between epigenetics, HCC pathology, article sets stage for further exploration novel investigational theranostic agents dynamic realm HCC.

Language: Английский

Citations

11
Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics DOI Creative Commons

Adham H. Mohamed,

Tasneem Abaza,

Y. A. Youssef

et al.

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Extracellular vesicles (EVs) are emerging tools in cancer diagnosis, prognosis and therapeutics.

Language: Английский

Citations

1
Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies DOI
Hannah Hisham Rashwan,

Ayman Taher,

H. A. Hassan

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155223 - 155223

Published: Feb. 23, 2024

Language: Английский

Citations

8
MIAT: A pivotal oncogenic long noncoding RNA tunning the hallmarks of solid malignancies DOI
Monica Mosaad Rostom,

Alaa A. Rashwan,

Christina D. Sotiropoulou

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102329 - 102329

Published: Feb. 26, 2025

Language: Английский

Citations

0
Deciphering the mysteries of MEG3 LncRNA and its implications in genitourinary cancers DOI Creative Commons
R.A. Assal, Hannah Hisham Rashwan, Z Zakaria

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 2, 2025

Maternally expressed gene 3 (MEG3), a long non-coding RNA, plays pivotal role in various biological processes, including tumorigenesis. Aberrant expression of MEG3 has been implicated several cancers, genitourinary malignancies. This comprehensive review explores the multifaceted functions context cancers through unravelling molecular mechanisms underlying influence on cellular proliferation, apoptosis, invasion, and metastasis. Additionally, we discuss potential clinical implications as biomarker therapeutic target cancers. By unraveling intricate these this aims to contribute development novel strategies for diagnosis treatment

Language: Английский

Citations

0
Genetic and Epigenetic Regulation of Non-coding RNAs: Implications in Cancer Metastasis, Stemness and Drug Resistance DOI
Tikam Chand Dakal, Ramila Philip, Ravi Bhushan

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155728 - 155728

Published: Nov. 28, 2024

Language: Английский

Citations

1
Epigenetics of cerebrovascular diseases: an update review of clinical studies DOI
Anna Maria Ciaccio, Antonino Tuttolomondo

Epigenomics, Journal Year: 2024, Volume and Issue: 16(14), P. 1043 - 1055

Published: July 17, 2024

Cerebrovascular diseases, especially stroke, are critical and heterogenous clinical conditions associated with high mortality chronic disability. Genome-wide association studies reveal substantial stroke heritability, though specific genetic variants account for a minor fraction of risk, suggesting an essential role the epigenome. Epigenome-wide candidate gene approaches show that DNA methylation patterns significantly influence susceptibility. Additionally, chromatin remodelers non-coding RNA regulate expression in response to ischemic conditions. In this updated review, we summarized progress knowledge on epigenetics field underlying opportunities challenges.

Language: Английский

Citations

0
Long noncoding RNA HSCHARME promotes the maturation of stem cells-derived cardiomyocytes by controlling gene regulatory networks altered in human cardiomyopathies DOI Creative Commons
Giulia Buonaiuto, Fabio Desideri,

Giulio Storari

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT A growing body of evidence suggests that tissue-specific long noncoding RNAs (lncRNA) play pivotal roles in the heart. Here, we exploited synteny between mouse and human genomes to identify novel lncRNA HSCHARME ( H uman S yntenic CHARME ) combined single-cell transcriptomics, CAGE-seq data, RNA-FISH imaging CRISPR-Cas9 genome editing document its role cardiomyogenesis. We found functional inactivation hiPSC-derived cardiomyocytes (CM) impairs expression calcium handling contraction genes, with a consequent decline CM maturation contractile functions. Consistent possible association disease, large-scale analysis across cardiomyopathy patients revealed increased levels hypertrophic (HCM) dilated (DCM) hearts identified subset diseased-associated targets whose can be modulated through dosage. Overall, our data unlock potential as non-coding regulator physiology open new possibilities for therapeutic application disease.

Language: Английский

Citations

0