Molecular Mechanisms and Therapeutic Implications of Long Non‐coding RNAs in Cutaneous Biology and Disease

Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(2)

Published: Feb. 1, 2025

ABSTRACT Human skin is the largest organ of human body and accounts for approximately fifteen percent total bodyweight. Its main physiological role to protect against a wide range environmental factors including pathogens, ultraviolet light, injury. Importantly, can regenerate heal upon injury in large part by differentiation keratinocytes. Not surprisingly, dysregulation cutaneous self‐renewal result variety skin‐related pathologies, autoimmune disease cancer. Increasing evidence supports premise that long non‐coding RNAs (lncRNAs) act as critical mediators gene expression regulate important biological processes within skin. Notably, lncRNAs has been shown influence diverse pathological consequences. More recently, numerous reports have revealed new mechanistic insight on play homeostasis well their contribution pathogenesis disorders. Here, we review functions impact homeostasis. We also describe fundamental roles disorders, fibrotic, autoimmune, malignant diseases. Lastly, will highlight how better understanding at molecular level may reveal novel therapeutic approaches improvement

Language: Английский

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miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Abstract Psoriasis is a chronic skin disorder marked by fast cell growth, leading to thick, red, scaly patches. MicroRNAs are small, non-coding RNA molecules that play crucial role in post-transcriptional gene regulation. This study investigates miR-16-5p, miR-21-5p, and miR-155-5p expression psoriasis EVs assesses their biomarker potential, exploring associated target genes pathways via bioinformatics. A cross-sectional case-control included 40 patients, with blood samples collected EDTA tubes. from extracellular vesicles was isolated using Qiagen kits, miRNAs were quantified RT-qPCR. Bioinformatic analysis predicted databases like miRDB TargetScan. Gene data GEO processed, differentially expressed identified. assessed patients’ circulating versus controls, finding significantly lower levels patients. ROC confirmed diagnostic potential. positive correlation of miR-16-5p the Area Severity Index (PASI) suggests severity marker Bioinformatics identified 378 common dysregulated genes, revealing key interactions psoriasis. heat map miRNA-mediated suppression disease. identifies as potential biomarkers, addition significant involved pathophysiology.

Language: Английский

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RNA-based diagnostic innovations: A new frontier in diabetes diagnosis and management

Diabetes and Vascular Disease Research, Journal Year: 2025, Volume and Issue: 22(2)

Published: March 1, 2025

Background/Objective: Diabetes mellitus (DM) remains a major global health challenge due to its chronic nature and associated complications. Traditional diagnostic approaches, though effective, often lack the sensitivity required for early-stage detection. Recent advancements in molecular biology have identified RNA molecules, particularly non-coding RNAs such as microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), promising biomarkers diabetes. This review aims explore role of RNA-based diagnosis, prognosis, management diabetes, highlighting their potential revolutionize diabetes care. Method: A comprehensive literature was conducted using electronic databases including PubMed, Scopus, Web Science. Articles published up 2024 were screened analyzed extract relevant findings related diagnostics Emphasis placed on studies demonstrating clinical utility, mechanistic insights, translational molecules. Results: Numerous species, miRNAs miR-375, miR-29, lncRNAs like H19 MEG3, exhibit altered expression patterns diabetic patients. These molecules are involved key regulatory pathways glucose metabolism, insulin resistance, β-cell function. Circulating detectable various biofluids, enabling non-invasive approaches. Emerging technologies, sequencing liquid biopsy platforms, enhanced specificity detection, fostering development novel tools personalized therapeutic strategies. Conclusion: hold significant promise advancing early risk stratification, monitoring Despite current challenges standardization validation, integration into routine practice could transform management, paving way precision medicine Further research multi-center trials essential validate these facilitate approval implementation.

Language: Английский

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Regulation of Different Types of Cell Death by Noncoding RNAs: Molecular Insights and Therapeutic Implications

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review

Biomarkers in Medicine, Journal Year: 2024, Volume and Issue: 18(19), P. 853 - 867

Published: July 9, 2024

Dermatologic disorders, affecting the integumentary system, involve diverse molecular mechanisms such as cell proliferation, apoptosis, inflammation and immune responses. Long noncoding RNAs, particularly Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1), are crucial regulators of gene expression. MALAT1 influences inflammatory responses, function signaling pathways, impacting various physiological pathological processes, including dermatologic disorders. Dysregulation is observed in skin conditions like psoriasis, atopic dermatitis systemic lupus erythematosus. However, its precise role remains unclear. This review consolidates knowledge on MALAT1's impact biology pathology, emphasizing potential diagnostic therapeutic implications conditions.

Language: Английский

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