Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity DOI Creative Commons
Feng Pan, Fan Yang, Dae Young Zang

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Chemotherapy-induced cardiotoxicity is a major adverse effect, driven by multiple factors in its pathogenesis. Notably, RNAs have emerged as significant contributors both cancer and heart failure (HF). carry genetic metabolic information that mirrors the current state of cells, making them valuable potential biomarkers therapeutic tools for diagnosing, predicting, treating range diseases, including cardiotoxicity. Over 97% genome transcribed into non-coding (ncRNAs), ribosomal RNA (rRNAs), transfer (tRNAs), newly identified microRNAs (miRNAs), circular (circRNAs), long (lncRNAs). NcRNAs function not only within their originating cells but also recipient being transported through extracellular compartments, referred to (exRNAs). Since ncRNAs were key regulators gene expression, numerous studies highlighted significance cardiovascular diseases. Nevertheless, role remains fully elucidated. The study aims review existing knowledge on Cardio-Oncology explore ncRNA-based therapies. These investigations could advance clinical application ncRNA research, improving early detection mitigating chemotherapy-induced

Language: Английский

Identification of S100A9 as a target for diagnosis and treatment of Crohn’s Disease after Vedolizumab treatment failure DOI Creative Commons

Yanru Zhang,

Zhe Zhang, Ruixian Liu

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: unknown, P. 107027 - 107027

Published: April 1, 2025

Language: Английский

Citations

0
Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity DOI Creative Commons
Feng Pan, Fan Yang, Dae Young Zang

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Chemotherapy-induced cardiotoxicity is a major adverse effect, driven by multiple factors in its pathogenesis. Notably, RNAs have emerged as significant contributors both cancer and heart failure (HF). carry genetic metabolic information that mirrors the current state of cells, making them valuable potential biomarkers therapeutic tools for diagnosing, predicting, treating range diseases, including cardiotoxicity. Over 97% genome transcribed into non-coding (ncRNAs), ribosomal RNA (rRNAs), transfer (tRNAs), newly identified microRNAs (miRNAs), circular (circRNAs), long (lncRNAs). NcRNAs function not only within their originating cells but also recipient being transported through extracellular compartments, referred to (exRNAs). Since ncRNAs were key regulators gene expression, numerous studies highlighted significance cardiovascular diseases. Nevertheless, role remains fully elucidated. The study aims review existing knowledge on Cardio-Oncology explore ncRNA-based therapies. These investigations could advance clinical application ncRNA research, improving early detection mitigating chemotherapy-induced

Language: Английский

Citations

0