Cited by MiR-192 and miR-731 synergically inhibit RGNNV infection by targeting ULK1-mediated autophagy in sea perch (Lateolabrax japonicus)

Characterizing Circulating microRNA Signatures of Type 2 Diabetes Subtypes DOI

Fatima Sulaiman, Costerwell Khyriem, Stafny Dsouza

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 637 - 637

Published: Jan. 14, 2025

Type 2 diabetes (T2D) is a heterogeneous disease influenced by both genetic and environmental factors. Recent studies suggest that T2D subtypes may exhibit distinct gene expression profiles. In this study, we aimed to identify cluster-specific miRNA signatures for the previously reported five clinical characterize underlying pathophysiology of long-standing T2D: severe insulin-resistant (SIRD), insulin-deficient (SIDD), mild age-related (MARD), obesity-related (MOD), early-onset (MEOD). We analyzed circulating microRNAs (miRNAs) in 45 subjects representing clusters 7 non-T2D healthy controls single-end small RNA sequencing. Bioinformatic analyses identified total 430 known miRNAs 13 unreported novel miRNAs. Of these, 71 were upregulated 37 downregulated either or individual clusters. Each subtype was associated with specific dysregulated profile, from controls. Specifically, 3 unique SIRD, 1 MARD, 9 MOD, 18 MEOD. Among miRNAs, 11 SIDD, Our study confirms heterogeneity T2D, represented distinguishable clinically epigenetically highlights potential as markers distinguishing subtypes.

Language: Английский

Citations

Circulating microRNAs and physical activity: Impact in diabetes DOI

Xiu Li, Jamal Hallajzadeh

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120178 - 120178

Published: Feb. 1, 2025

Language: Английский

Citations

The miRNomics of antiretroviral therapy-induced obesity DOI