The Role of Non-Coding RNAs in Gene Regulation and Cellular Signaling Pathways

International Journal of Innovations in Science Engineering and Management., Journal Year: 2025, Volume and Issue: unknown, P. 174 - 180

Published: Feb. 22, 2025

Evidence has been mounting over the last decade demonstrating crucial functions of ncRNAs, including miRNAs and long non-coding RNAs (lncRNAs), in cellular signalling networks gene regulation. These ncRNAs are highly expressed play a role regulating processes metastasis endothelial cell invasiveness. They facilitate crosstalk between interconnected signaling pathways, PTEN/PI3K/AKT/mTOR, by acting as linking molecules within signal circuits. In addition to expression conventional apical measures, studying provides better understanding both beneficial detrimental reactions external exposures. Additionally, miRNAs—which may be found extracellular intracellular environments, such biofluids—have become potential early precise molecular indicators tissue conditions. This review highlights regulatory their involvement homeostasis, biomarkers, shedding light on significance regulation, toxicological studies, precision medicine.

Language: Английский

Role of long non-coding RNAs in the regulation of ferroptosis in tumors

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Normal cells begin to grow indefinitely and immortalize form tumor after an external stimulus resulting in a genetic mutation. Effective killing of is the basis various cancer therapies. Ferroptosis class cell death types dependent on iron cellular lipid peroxidation. Tumors themselves are iron-dependent, conventional radiotherapy also sensitizes ferroptosis. Increasing sensitivity ferroptosis may be potential therapeutic strategy overcome resistance mechanisms therapy. Long noncoding RNAs (LncRNAs) transcripts more than 200 nucleotides length that regulate gene expression at multiple levels involved biological processes such as differentiation, cycle arrest, maintenance stemness. Recent studies have found lncRNAs through influence or ameliorate chemotherapeutic agents. With continuous maturation nanomaterials technology, it provide new means for treatment by regulating ferroptosis-related inside tumors well increasing Fe 2+ ROS tumors. In this paper, we systematically introduce regulatory mechanism ferroptosis, role immunotherapy application combined with nanomaterials, which provides perspectives

Language: Английский

Differential expression and correlation analysis of global transcriptome for obstructive sleep apnea hypopnea syndrome

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

In order to investigate the gene expression patterns and molecular regulatory mechanisms of obstructive sleep apnea hypopnea syndrome (OSAHS), global transcriptome profiles OSAHS patients healthy people were analyzed using sequencing technology. Differential circular RNA, microRNA, long noncoding messenger RNA was investigated between two groups. To further explore role differentially expressed genes in OSAHS, we functionally annotated enrichment analysis GO KEGG pathways. Finally, ceRNA network constructed. And validate mRNA through qRT-PCR analysis. The results showed that 349 circRNAs,552 lncRNAs,205 miRNAs, 502 mRNAs with compared population. Terms such as centrosome, positive regulation execution phase apoptosis, oxidoreductase activity, Th 17 cell differentiation immune response, neutrophil mediated cytotoxicity enriched list, suggesting a potential correlation OSAHS. Pathway Ferroptosis, Herpes simplex virus 1 infection, Pathways cancer, Hematopoietic lineage other pathways play an important By constructing ternary network, circRNAs four lncRNAs screened ceRNAs compete miRNAs co-expression associated by regulating function network. quaternary miR-8485 miR-6089 found be top ranked most closely Both similar trends. This provides more theoretical basis for exploring complex development

Language: Английский