The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis DOI Open Access
Rogelio F. Jiménez-Ortega, Diana I. Aparicio‐Bautista,

Adriana Becerra‐Cervera

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4273 - 4273

Published: April 30, 2025

Osteoporosis (OP) is a disease affecting bone metabolism, characterized by low mineral density and the deterioration of microarchitecture, leading to increased fragility risk fracture. OP mainly results from alterations in balance between osteoclast-mediated resorption osteoblast-mediated formation. Currently, there are several molecular mechanisms underlying development that not entirely clear. One such mechanism role long non-coding RNAs, which key regulators gene expression through various mechanisms. In last decade, it has been shown these molecules participate multiple biological processes play essential roles pathogenesis different diseases. this review, we address recent advances on relationship RNAs with OP, over their regulatory functions during osteoclastogenesis osteogenesis. Furthermore, analyze potential application as clinical or therapeutic resources focused OP.

Language: Английский

The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis DOI Open Access
Rogelio F. Jiménez-Ortega, Diana I. Aparicio‐Bautista,

Adriana Becerra‐Cervera

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4273 - 4273

Published: April 30, 2025

Osteoporosis (OP) is a disease affecting bone metabolism, characterized by low mineral density and the deterioration of microarchitecture, leading to increased fragility risk fracture. OP mainly results from alterations in balance between osteoclast-mediated resorption osteoblast-mediated formation. Currently, there are several molecular mechanisms underlying development that not entirely clear. One such mechanism role long non-coding RNAs, which key regulators gene expression through various mechanisms. In last decade, it has been shown these molecules participate multiple biological processes play essential roles pathogenesis different diseases. this review, we address recent advances on relationship RNAs with OP, over their regulatory functions during osteoclastogenesis osteogenesis. Furthermore, analyze potential application as clinical or therapeutic resources focused OP.

Language: Английский

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